RT06_MOUSE
ID RT06_MOUSE Reviewed; 125 AA.
AC P58064;
DT 04-MAY-2001, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=28S ribosomal protein S6, mitochondrial;
DE Short=MRP-S6;
DE Short=S6mt;
GN Name=Mrps6; Synonyms=Rpms6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11402041; DOI=10.1074/jbc.m103236200;
RA Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A.,
RA Watanabe K.;
RT "Proteomic analysis of the mammalian mitochondrial ribosome. Identification
RT of protein components in the 28S small subunit.";
RL J. Biol. Chem. 276:33181-33195(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12036297; DOI=10.1006/geno.2002.6781;
RA Reymond A., Camargo A.A., Deutsch S., Stevenson B.J., Parmigiani R.B.,
RA Ucla C., Bettoni F., Rossier C., Lyle R., Guipponi M., de Souza S.,
RA Iseli C., Jongeneel C.V., Bucher P., Simpson A.J.G., Antonarakis S.E.;
RT "Nineteen additional unpredicted transcripts from human chromosome 21.";
RL Genomics 79:824-832(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, and Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Component of the mitochondrial ribosome small subunit (28S)
CC which comprises a 12S rRNA and about 30 distinct proteins.
CC {ECO:0000250|UniProtKB:P82932}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P82932}.
CC -!- SIMILARITY: Belongs to the bacterial ribosomal protein bS6 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB40996.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB049943; BAB40996.1; ALT_INIT; mRNA.
DR EMBL; AY061856; AAL35740.1; -; mRNA.
DR EMBL; BC027271; AAH27271.1; -; mRNA.
DR CCDS; CCDS28332.1; -.
DR RefSeq; NP_536704.1; NM_080456.1.
DR AlphaFoldDB; P58064; -.
DR SMR; P58064; -.
DR ComplexPortal; CPX-5301; 28S mitochondrial small ribosomal subunit.
DR STRING; 10090.ENSMUSP00000037631; -.
DR iPTMnet; P58064; -.
DR PhosphoSitePlus; P58064; -.
DR EPD; P58064; -.
DR PaxDb; P58064; -.
DR PeptideAtlas; P58064; -.
DR PRIDE; P58064; -.
DR ProteomicsDB; 262718; -.
DR Antibodypedia; 35213; 71 antibodies from 17 providers.
DR Ensembl; ENSMUST00000047429; ENSMUSP00000037631; ENSMUSG00000039680.
DR GeneID; 121022; -.
DR KEGG; mmu:121022; -.
DR UCSC; uc007zyu.1; mouse.
DR CTD; 64968; -.
DR MGI; MGI:2153111; Mrps6.
DR VEuPathDB; HostDB:ENSMUSG00000039680; -.
DR eggNOG; KOG4708; Eukaryota.
DR GeneTree; ENSGT00390000014606; -.
DR HOGENOM; CLU_126331_4_2_1; -.
DR InParanoid; P58064; -.
DR OMA; MTKHNQR; -.
DR PhylomeDB; P58064; -.
DR TreeFam; TF314045; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 121022; 21 hits in 72 CRISPR screens.
DR ChiTaRS; Mrps6; mouse.
DR PRO; PR:P58064; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; P58064; protein.
DR Bgee; ENSMUSG00000039680; Expressed in vestibular membrane of cochlear duct and 248 other tissues.
DR ExpressionAtlas; P58064; baseline and differential.
DR Genevisible; P58064; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005763; C:mitochondrial small ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0070181; F:small ribosomal subunit rRNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; ISS:UniProtKB.
DR GO; GO:0032543; P:mitochondrial translation; ISS:UniProtKB.
DR Gene3D; 3.30.70.60; -; 1.
DR InterPro; IPR000529; Ribosomal_S6.
DR InterPro; IPR035980; Ribosomal_S6_sf.
DR InterPro; IPR014717; Transl_elong_EF1B/ribosomal_S6.
DR PANTHER; PTHR21011; PTHR21011; 1.
DR Pfam; PF01250; Ribosomal_S6; 1.
DR SUPFAM; SSF54995; SSF54995; 1.
DR TIGRFAMs; TIGR00166; S6; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..125
FT /note="28S ribosomal protein S6, mitochondrial"
FT /id="PRO_0000176893"
SQ SEQUENCE 125 AA; 14309 MW; 8140DB0DBFDD9025 CRC64;
MPRYELALIL KAMRRPETAA ALKRTIESLM DRGAIVRNLE SLGERALPYR ISSHSQQHSR
GGYFLVDFYA PTSAVENILE HLARDIDVVR PNIVKHPLTQ EVKECDGIVP VPLEEKLYST
KRRKK
