ID   B2MG_DANRE              Reviewed;         116 AA.
AC   Q04475;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=Beta-2-microglobulin;
DE   Flags: Precursor;
GN   Name=b2m;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=8462988; DOI=10.1007/bf00216384;
RA   Ono H., Figueroa F., O'Huigin C., Klein K.A.;
RT   "Cloning of the beta 2-microglobulin gene in the zebrafish.";
RL   Immunogenetics 38:1-10(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the class I major histocompatibility complex
CC       (MHC). Involved in the presentation of peptide antigens to the immune
CC       system (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain. Beta-2-
CC       microglobulin is the beta-chain of major histocompatibility complex
CC       class I molecules (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-2-microglobulin family. {ECO:0000305}.
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DR   EMBL; L05383; AAA50022.1; -; mRNA.
DR   EMBL; L05384; AAA50023.1; -; Genomic_DNA.
DR   EMBL; BC062841; AAH62841.1; -; mRNA.
DR   PIR; I51732; I51733.
DR   RefSeq; NP_001153240.1; NM_001159768.1.
DR   RefSeq; NP_571238.1; NM_131163.2.
DR   PDB; 4M9O; X-ray; 2.14 A; A=19-116.
DR   PDBsum; 4M9O; -.
DR   AlphaFoldDB; Q04475; -.
DR   SMR; Q04475; -.
DR   STRING; 7955.ENSDARP00000069612; -.
DR   PaxDb; Q04475; -.
DR   Ensembl; ENSDART00000075127; ENSDARP00000069612; ENSDARG00000053136.
DR   Ensembl; ENSDART00000131026; ENSDARP00000110049; ENSDARG00000053136.
DR   GeneID; 30400; -.
DR   KEGG; dre:30400; -.
DR   CTD; 567; -.
DR   ZFIN; ZDB-GENE-980526-88; b2m.
DR   eggNOG; ENOG502S8GM; Eukaryota.
DR   GeneTree; ENSGT00940000165013; -.
DR   HOGENOM; CLU_163066_1_0_1; -.
DR   InParanoid; Q04475; -.
DR   OMA; ICKVNHA; -.
DR   OrthoDB; 1556447at2759; -.
DR   PhylomeDB; Q04475; -.
DR   TreeFam; TF334167; -.
DR   Reactome; R-DRE-2132295; MHC class II antigen presentation.
DR   PRO; PR:Q04475; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 4.
DR   Bgee; ENSDARG00000053136; Expressed in pharyngeal gill and 24 other tissues.
DR   ExpressionAtlas; Q04475; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0042613; C:MHC class II protein complex; IBA:GO_Central.
DR   GO; GO:0023026; F:MHC class II protein complex binding; IBA:GO_Central.
DR   GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IBA:GO_Central.
DR   GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IBA:GO_Central.
DR   GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
DR   CDD; cd05770; IgC_beta2m; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR015707; B2Microglobulin.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   PANTHER; PTHR19944:SF62; PTHR19944:SF62; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Disulfide bond; Immunity; Immunoglobulin domain; MHC I;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..116
FT                   /note="Beta-2-microglobulin"
FT                   /id="PRO_0000018807"
FT   DOMAIN          24..111
FT                   /note="Ig-like C1-type"
FT   DISULFID        44..99
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   STRAND          25..32
FT                   /evidence="ECO:0007829|PDB:4M9O"
FT   STRAND          40..48
FT                   /evidence="ECO:0007829|PDB:4M9O"
FT   STRAND          50..52
FT                   /evidence="ECO:0007829|PDB:4M9O"
FT   STRAND          55..60
FT                   /evidence="ECO:0007829|PDB:4M9O"
FT   STRAND          74..76
FT                   /evidence="ECO:0007829|PDB:4M9O"
FT   TURN            77..79
FT                   /evidence="ECO:0007829|PDB:4M9O"
FT   STRAND          80..89
FT                   /evidence="ECO:0007829|PDB:4M9O"
FT   STRAND          97..103
FT                   /evidence="ECO:0007829|PDB:4M9O"
FT   STRAND          106..111
FT                   /evidence="ECO:0007829|PDB:4M9O"
SQ   SEQUENCE   116 AA;  13289 MW;  D2F3766C9A2BDBEB CRC64;
     MRALITFALL CLLYITVQGK VSTPKVHVYS HFPGEYGKPN TLICYVSSFH PPDISIELLK
     NGQVMSDTKQ TDLAFEKGWQ FHLTKSVAFT PEKGDEYTCS VRHMKETKKF SWEPNM