ID   B2MG_CAVPO              Reviewed;          99 AA.
AC   P01886;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=Beta-2-microglobulin;
GN   Name=B2M;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=6170877; DOI=10.1016/0161-5890(80)90175-3;
RA   Wolfe P.B., Cebra J.J.;
RT   "The primary structure of guinea pig beta 2-microglobulin.";
RL   Mol. Immunol. 17:1493-1505(1980).
CC   -!- FUNCTION: Component of the class I major histocompatibility complex
CC       (MHC). Involved in the presentation of peptide antigens to the immune
CC       system (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain. Beta-2-
CC       microglobulin is the beta-chain of major histocompatibility complex
CC       class I molecules (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-2-microglobulin family. {ECO:0000305}.
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DR   PIR; A02181; MGGPB2.
DR   AlphaFoldDB; P01886; -.
DR   SMR; P01886; -.
DR   STRING; 10141.ENSCPOP00000002661; -.
DR   eggNOG; ENOG502S8GM; Eukaryota.
DR   HOGENOM; CLU_163066_0_0_1; -.
DR   InParanoid; P01886; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   CDD; cd05770; IgC_beta2m; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR015707; B2Microglobulin.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   PANTHER; PTHR19944:SF62; PTHR19944:SF62; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Immunity; Immunoglobulin domain;
KW   MHC I; Reference proteome; Secreted.
FT   CHAIN           1..99
FT                   /note="Beta-2-microglobulin"
FT                   /id="PRO_0000080732"
FT   DOMAIN          5..93
FT                   /note="Ig-like C1-type"
FT   DISULFID        25..80
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   99 AA;  11417 MW;  60E2AECAF106BA76 CRC64;
     VLHAPRVQVY SRHPAENGKQ NFINCYVSGF HPPQIEVELL KNGKKIDNVE MSDLSFSKDW
     TFYLLVHAAF TPNDSDEYSC RVSHITLSEP KIVKWDPNK