ID   RQCH_METJA              Reviewed;         671 AA.
AC   Q59020;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Archaeal Rqc2 homolog aRqcH {ECO:0000255|HAMAP-Rule:MF_00844, ECO:0000303|PubMed:31155236};
DE            Short=aRqcH {ECO:0000255|HAMAP-Rule:MF_00844, ECO:0000303|PubMed:31155236};
GN   Name=rqcH {ECO:0000255|HAMAP-Rule:MF_00844, ECO:0000303|PubMed:31155236};
GN   OrderedLocusNames=MJ1625;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
RN   [2]
RP   POSSIBLE FUNCTION.
RX   PubMed=31155236; DOI=10.1016/j.cell.2019.05.002;
RA   Lytvynenko I., Paternoga H., Thrun A., Balke A., Mueller T.A., Chiang C.H.,
RA   Nagler K., Tsaprailis G., Anders S., Bischofs I., Maupin-Furlow J.A.,
RA   Spahn C.M.T., Joazeiro C.A.P.;
RT   "Alanine Tails Signal Proteolysis in Bacterial Ribosome-Associated Quality
RT   Control.";
RL   Cell 0:0-0(2019).
CC   -!- FUNCTION: Probably part of the ribosome quality control system (RQC).
CC       May mediate the addition of alanine residues (Ala tailing) to
CC       incompletely synthesized nascent chains from stalled ribosomes, leading
CC       to their degradation. {ECO:0000255|HAMAP-Rule:MF_00844,
CC       ECO:0000305|PubMed:31155236}.
CC   -!- SUBUNIT: Associates with stalled 50S ribosomal subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00844}.
CC   -!- SIMILARITY: Belongs to the NEMF family. {ECO:0000255|HAMAP-
CC       Rule:MF_00844}.
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DR   EMBL; L77117; AAB99643.1; -; Genomic_DNA.
DR   PIR; H64502; H64502.
DR   RefSeq; WP_010871150.1; NC_000909.1.
DR   AlphaFoldDB; Q59020; -.
DR   SMR; Q59020; -.
DR   STRING; 243232.MJ_1625; -.
DR   PRIDE; Q59020; -.
DR   EnsemblBacteria; AAB99643; AAB99643; MJ_1625.
DR   GeneID; 1452535; -.
DR   KEGG; mja:MJ_1625; -.
DR   eggNOG; arCOG01695; Archaea.
DR   HOGENOM; CLU_003612_2_1_2; -.
DR   InParanoid; Q59020; -.
DR   OMA; MVYGKRN; -.
DR   OrthoDB; 69351at2157; -.
DR   PhylomeDB; Q59020; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:1990112; C:RQC complex; IBA:GO_Central.
DR   GO; GO:0043023; F:ribosomal large subunit binding; IBA:GO_Central.
DR   GO; GO:0000049; F:tRNA binding; IBA:GO_Central.
DR   GO; GO:0072344; P:rescue of stalled ribosome; IBA:GO_Central.
DR   HAMAP; MF_00844_A; RqcH_A; 1.
DR   InterPro; IPR008532; NFACT_RNA-bd.
DR   InterPro; IPR010979; Ribosomal_S13-like_H2TH.
DR   InterPro; IPR043681; RqcH_archaeal.
DR   Pfam; PF05670; NFACT-R_1; 1.
DR   SUPFAM; SSF46946; SSF46946; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Protein biosynthesis; Reference proteome; RNA-binding;
KW   tRNA-binding.
FT   CHAIN           1..671
FT                   /note="Archaeal Rqc2 homolog aRqcH"
FT                   /id="PRO_0000107445"
FT   COILED          291..363
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00844"
FT   COILED          410..465
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00844"
SQ   SEQUENCE   671 AA;  78616 MW;  49BB5EE873CF6A86 CRC64;
     MKSEITNVDV CCVVDELQNL INGRLDKAFL IDNEQNRELI LKIHVPEGGS RELVISIGKY
     KYITLTNYER EKPKLPPSFA MLLRKYLKNA KLIKIEQVNF DRVVIFHFET RDGIYKLVAE
     LFGDGNIIFL NNEDTIIAPL RVERWSTRNI VPKEKYKFPP QKPLNPYNLE FSIAYEVFKD
     YFLNNKGVEC VRLISRVFGI GGLYAEEICE RAEIDKKKRD LSEEEIKKLF EASKNLFDEI
     FNNRKPQIVL KDNEYFDVVP IDLKKYKGLE KKYYNSFLEA VDDYFAKFLT KVVVKKEKSK
     IEKEIERQEN ILRRQLETLK KYKEDAEKNQ IKGDLIYANY QIVEELLNAI RQAREKMDWA
     RIKKIIRENK EHPILGLIEN INENIGEIII RLKSEVDDKV IEERVSLDIR KNAFENAESY
     YEKAKKLRNK IEGIENAIEL TKKKIEELKK KGEEELKEKE SMQMKKKIRK ERKWYEKFKW
     TVINGFLVIA GKDAITNEII IKKYTDKDDI VFHADIQGAP FTVIKTQGKE VDEETLEEVA
     KFSVSHSRAW KLGYGAIDTY WVKPEQISKT AESGEYLKRG AFVIRGERHY YRNTPLELGV
     GVIEYDGDVK ITTAPPKTLQ KSFIKWVLLK PSNKEKGKVV KELKEIFKDY GIDDEDILRV
     LPPGGCEIVK K