AUL1_ARATH
ID AUL1_ARATH Reviewed; 1450 AA.
AC Q9FWS1; F4HZ18; O81812; Q9FRM2;
DT 18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
DT 18-SEP-2013, sequence version 2.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Auxilin-like protein 1;
GN Name=AUL1; OrderedLocusNames=At1g75310; ORFNames=F1B16.14, F22H5.15;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1003-1450 (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=10561504; DOI=10.1016/s0014-5793(99)01426-x;
RA Quesada V., Ponce M.R., Micol J.L.;
RT "OTC and AUL1, two convergent and overlapping genes in the nuclear genome
RT of Arabidopsis thaliana.";
RL FEBS Lett. 461:101-106(1999).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9FWS1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9FWS1-2; Sequence=VSP_047850;
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice
CC site. {ECO:0000305}.
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DR EMBL; AC023754; AAG13076.1; -; Genomic_DNA.
DR EMBL; AC025814; AAG12690.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE35700.1; -; Genomic_DNA.
DR EMBL; AJ007450; CAA07520.1; -; mRNA.
DR PIR; F96783; F96783.
DR PIR; T51618; T51618.
DR RefSeq; NP_177666.1; NM_106186.2. [Q9FWS1-2]
DR AlphaFoldDB; Q9FWS1; -.
DR SMR; Q9FWS1; -.
DR STRING; 3702.AT1G75310.1; -.
DR iPTMnet; Q9FWS1; -.
DR PaxDb; Q9FWS1; -.
DR PRIDE; Q9FWS1; -.
DR ProteomicsDB; 241147; -. [Q9FWS1-1]
DR EnsemblPlants; AT1G75310.1; AT1G75310.1; AT1G75310. [Q9FWS1-2]
DR GeneID; 843868; -.
DR Gramene; AT1G75310.1; AT1G75310.1; AT1G75310. [Q9FWS1-2]
DR KEGG; ath:AT1G75310; -.
DR Araport; AT1G75310; -.
DR TAIR; locus:2018462; AT1G75310.
DR eggNOG; KOG0431; Eukaryota.
DR HOGENOM; CLU_004791_0_0_1; -.
DR PRO; PR:Q9FWS1; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9FWS1; baseline and differential.
DR Genevisible; Q9FWS1; AT.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0031982; C:vesicle; IBA:GO_Central.
DR GO; GO:0030276; F:clathrin binding; IBA:GO_Central.
DR GO; GO:0072318; P:clathrin coat disassembly; IBA:GO_Central.
DR GO; GO:0072583; P:clathrin-dependent endocytosis; IBA:GO_Central.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036869; J_dom_sf.
DR SUPFAM; SSF46565; SSF46565; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..1450
FT /note="Auxilin-like protein 1"
FT /id="PRO_0000423422"
FT DOMAIN 1377..1450
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT REGION 117..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 241..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 357..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 908..946
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 961..1046
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1077..1168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1192..1241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1254..1328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 316..344
FT /evidence="ECO:0000255"
FT COILED 1142..1184
FT /evidence="ECO:0000255"
FT COILED 1219..1257
FT /evidence="ECO:0000255"
FT COILED 1327..1355
FT /evidence="ECO:0000255"
FT COMPBIAS 245..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..374
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..572
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 908..927
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 928..946
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 999..1046
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1086..1104
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1118..1168
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1192..1222
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1263..1309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1312..1328
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1306..1307
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_047850"
FT CONFLICT 1447
FT /note="A -> V (in Ref. 3; CAA07520)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1450 AA; 162046 MW; 1A3C21D0046F3EDA CRC64;
MEYEKSPTAT TFSRKISNNR SHSLSFSANA VYDGVFSSPV NSKSPLVDYG EIFRGSGPSP
SSIPFLDVPE LNVGKVKVDV RSSKLDYSSV FGGLGACDFA VTPKEVIIKS EKKTSINEDK
KRNRRKGGNS SDVPLCNEGK KSPEMVRMKH SDISYHQTVP RNENGATHLT QVPATMPGPI
PTQVVDNTSL LHKIESKSTP IPAVEKKLPC NEGREEVKAS RKQGSKTEVD FENIFARDGC
STRDDSTCKT VSNGEYRDVK PPSSFQCTLN GEHGASERLS GLNSGPSERY ETEDADSPSS
PPYFDAETDE NSVAAESSAA LKKAIEEAQI RMNIAKQMME KKKSGFRSCA KLKSCDDSKI
ENKGNTKVEG ITEESRDNNS QILGEMVKPS EQSFSNEGDQ HAKRARKLWG VPEGLLKSTS
DHKPEELEEQ DIITLEEEQA RRGRKHWELP GGIFKSVMNS KQQEPENLAP AKPEPDTKQE
VQPITENPFY TFGQLGSKLK CVVEAFTGSK VSQKDEKQFT EKENSTVTQM VQDEESDSQE
MLAGIPVIET YLREVEETPQ QTESKSEMNI EEKSESTICA FTERSSQNME KETGWQVKSA
CKFEDGSGVK DFQENGDHTC NVLDQEGEKE IVSEPQEMLV GPDDSKTYVR EVEETPTPSL
NKTQSDDSVG AMVSFNRVNI SEPGNIDEVQ EAVHKVPRRR RVWKTSEDVY NMIKAPKGNN
RPWQLESAEN ETTAMSFHEE GVRIHHASEE IESTSGQASD SGLQENWTVL KQMFRQMFQT
ADTKGEDETY CLVESERGHL DIHQKAQEKY EQVEVETVRT NYEAYAHTRE NEDESAQETY
CRKEDGKVEV QGKTSLVREL IGEELEMASL EEEDVQEASE EAGWVQGLSE LNEINEHADS
HAEMLEYDRS ETDSNNSRER FDQTQEQAEE TMIDGSIDTD TSRSSFEMRQ GDSYIEEVGI
EQHRSDQFPE KASAVSNTEE HIEEIDSDSI QSGWSVVEDD DRSLQDGGAS QAESKHDELE
ETKEESDEMK TSLGVERNGD KKELEHQFEC QENETYRSNV EAAESSCRFP NGEEIIGAAT
NGNMKENEGE EGEESCRSSM EEEGDATSDI GAATDGNMKE NEGEESCRSS MEEEGDATSD
ISQNKAETVE EHLKKIDETR EKERERKQER VMVERAIREA RERAFADAME RAGKTAMEKA
KAVAHRREVP RKSEKGSVEV NDKLSSAEKA SMQAKLRAER AAVERAITEV RERAMEKALS
GKSAASQAKS YGGSKSFSSS GERRGSSSSG TENKSSGPSN SSNQTAKGEP IQRCKARSER
HQRTSDRAAE ALAEKKLRDL KTQKEQTERN RLAEALDADV KRWSSGKENN LRALISTLQY
ILGAESGWKP IPLTDLVSSA SVRKAYRKAT LYVHPDKLQQ RGASTQQKYI CEKVFDLLKE
AWNKFGADER
