ID   AUGN_XENTR              Reviewed;         135 AA.
AC   Q5FVX5;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Augurin {ECO:0000305};
DE   Flags: Precursor;
GN   Name=ecrg4;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable hormone that may attenuate cell proliferation and
CC       induce senescence in the central nervous system.
CC       {ECO:0000250|UniProtKB:D4A540}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9H1Z8}.
CC       Cytoplasm {ECO:0000250|UniProtKB:Q9H1Z8}. Apical cell membrane
CC       {ECO:0000250|UniProtKB:Q9H1Z8}.
CC   -!- SIMILARITY: Belongs to the augurin family. {ECO:0000305}.
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DR   EMBL; BC089724; AAH89724.1; -; mRNA.
DR   RefSeq; NP_001015782.2; NM_001015782.1.
DR   AlphaFoldDB; Q5FVX5; -.
DR   PaxDb; Q5FVX5; -.
DR   DNASU; 548499; -.
DR   GeneID; 548499; -.
DR   KEGG; xtr:548499; -.
DR   CTD; 84417; -.
DR   Xenbase; XB-GENE-997587; ecrg4.
DR   eggNOG; ENOG502RZPP; Eukaryota.
DR   HOGENOM; CLU_153579_0_0_1; -.
DR   InParanoid; Q5FVX5; -.
DR   OrthoDB; 1431738at2759; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR   GO; GO:0090398; P:cellular senescence; IBA:GO_Central.
DR   GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR   GO; GO:0070314; P:G1 to G0 transition; IBA:GO_Central.
DR   GO; GO:0042127; P:regulation of cell population proliferation; IBA:GO_Central.
DR   InterPro; IPR028173; Augurin.
DR   PANTHER; PTHR31613; PTHR31613; 1.
DR   Pfam; PF15187; Augurin; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cleavage on pair of basic residues; Cytoplasm; Membrane;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000250|UniProtKB:D4A540"
FT   PROPEP          19..55
FT                   /evidence="ECO:0000250|UniProtKB:D4A540"
FT                   /id="PRO_0000446070"
FT   PEPTIDE         58..119
FT                   /note="Augurin"
FT                   /id="PRO_0000359771"
FT   PROPEP          120..135
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000363246"
SQ   SEQUENCE   135 AA;  15949 MW;  17B233C22F5CFFDA CRC64;
     MVLLFLLVIF LCPGSTNGNK LRLMLQKREA GEPSKTIVSV KENKANEFLN SLKRPKRQLW
     DRTRPEVQQW YQQFLYMGFD EQKYEDDLSY WMSQGRGGSE YYGGFHQHHY DEDAPIGPRN
     PYTFRHGAGV NYDDY