AUGN_HUMAN
ID AUGN_HUMAN Reviewed; 148 AA.
AC Q9H1Z8; D3DVK2;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Augurin {ECO:0000305};
DE AltName: Full=Esophageal cancer-related gene 4 protein {ECO:0000303|Ref.1};
DE Short=ECRG4 {ECO:0000303|PubMed:21349154};
DE Flags: Precursor;
GN Name=ECRG4 {ECO:0000312|HGNC:HGNC:24642}; Synonyms=C2orf40;
GN ORFNames=UNQ761/PRO1508;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Bi M., Lu S.;
RT "Cloning of esophageal cancer related gene 4 (ECRG4).";
RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=21349154; DOI=10.1186/2045-8118-8-6;
RA Gonzalez A.M., Podvin S., Lin S.Y., Miller M.C., Botfield H.,
RA Leadbeater W.E., Roberton A., Dang X., Knowling S.E., Cardenas-Galindo E.,
RA Donahue J.E., Stopa E.G., Johanson C.E., Coimbra R., Eliceiri B.P.,
RA Baird A.;
RT "Ecrg4 expression and its product augurin in the choroid plexus: impact on
RT fetal brain development, cerebrospinal fluid homeostasis and
RT neuroprogenitor cell response to CNS injury.";
RL Fluids Barriers CNS 8:6-6(2011).
CC -!- FUNCTION: Probable hormone that may attenuate cell proliferation and
CC induce senescence of oligodendrocyte and neural precursor cells in the
CC central nervous system (By similarity). ECRG4-induced senescence is
CC characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1
CC and CCND3 proteasomal degradation (By similarity).
CC {ECO:0000250|UniProtKB:D4A540}.
CC -!- INTERACTION:
CC Q9H1Z8; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-12208839, EBI-947187;
CC Q9H1Z8; O76024: WFS1; NbExp=3; IntAct=EBI-12208839, EBI-720609;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21349154}. Cytoplasm
CC {ECO:0000269|PubMed:21349154}. Apical cell membrane
CC {ECO:0000269|PubMed:21349154}.
CC -!- TISSUE SPECIFICITY: Expressed in the brain, with expression in the
CC epithelial cell layer of the choroid plexus (at protein level).
CC {ECO:0000269|PubMed:21349154}.
CC -!- SIMILARITY: Belongs to the augurin family. {ECO:0000305}.
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DR EMBL; AF325503; AAG42321.1; -; mRNA.
DR EMBL; AY358601; AAQ88964.1; -; mRNA.
DR EMBL; AC018878; AAY15084.1; -; Genomic_DNA.
DR EMBL; CH471127; EAX01751.1; -; Genomic_DNA.
DR EMBL; CH471127; EAX01752.1; -; Genomic_DNA.
DR EMBL; BC021742; AAH21742.1; -; mRNA.
DR CCDS; CCDS2072.1; -.
DR RefSeq; NP_115787.1; NM_032411.2.
DR AlphaFoldDB; Q9H1Z8; -.
DR BioGRID; 124069; 3.
DR IntAct; Q9H1Z8; 2.
DR STRING; 9606.ENSP00000238044; -.
DR iPTMnet; Q9H1Z8; -.
DR PhosphoSitePlus; Q9H1Z8; -.
DR BioMuta; C2orf40; -.
DR MassIVE; Q9H1Z8; -.
DR PaxDb; Q9H1Z8; -.
DR PeptideAtlas; Q9H1Z8; -.
DR PRIDE; Q9H1Z8; -.
DR ProteomicsDB; 80461; -.
DR Antibodypedia; 2376; 226 antibodies from 28 providers.
DR DNASU; 84417; -.
DR Ensembl; ENST00000238044.8; ENSP00000238044.3; ENSG00000119147.10.
DR GeneID; 84417; -.
DR KEGG; hsa:84417; -.
DR MANE-Select; ENST00000238044.8; ENSP00000238044.3; NM_032411.3; NP_115787.1.
DR UCSC; uc010fjf.4; human.
DR CTD; 84417; -.
DR DisGeNET; 84417; -.
DR GeneCards; ECRG4; -.
DR HGNC; HGNC:24642; ECRG4.
DR HPA; ENSG00000119147; Tissue enhanced (choroid).
DR MIM; 611752; gene.
DR neXtProt; NX_Q9H1Z8; -.
DR OpenTargets; ENSG00000119147; -.
DR PharmGKB; PA147358728; -.
DR VEuPathDB; HostDB:ENSG00000119147; -.
DR eggNOG; ENOG502RZPP; Eukaryota.
DR GeneTree; ENSGT00390000000145; -.
DR InParanoid; Q9H1Z8; -.
DR OMA; RNGHDYD; -.
DR OrthoDB; 1431738at2759; -.
DR PhylomeDB; Q9H1Z8; -.
DR TreeFam; TF336161; -.
DR PathwayCommons; Q9H1Z8; -.
DR SignaLink; Q9H1Z8; -.
DR BioGRID-ORCS; 84417; 5 hits in 1050 CRISPR screens.
DR ChiTaRS; C2orf40; human.
DR GenomeRNAi; 84417; -.
DR Pharos; Q9H1Z8; Tbio.
DR PRO; PR:Q9H1Z8; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q9H1Z8; protein.
DR Bgee; ENSG00000119147; Expressed in mucosa of stomach and 160 other tissues.
DR ExpressionAtlas; Q9H1Z8; baseline and differential.
DR Genevisible; Q9H1Z8; HS.
DR GO; GO:0016324; C:apical plasma membrane; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0031045; C:dense core granule; IDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0005184; F:neuropeptide hormone activity; IGI:UniProtKB.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR GO; GO:0090398; P:cellular senescence; IBA:GO_Central.
DR GO; GO:0007417; P:central nervous system development; ISS:UniProtKB.
DR GO; GO:0070314; P:G1 to G0 transition; IBA:GO_Central.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IGI:UniProtKB.
DR GO; GO:2000854; P:positive regulation of corticosterone secretion; IGI:UniProtKB.
DR GO; GO:0051461; P:positive regulation of corticotropin secretion; IGI:UniProtKB.
DR GO; GO:0051466; P:positive regulation of corticotropin-releasing hormone secretion; IGI:UniProtKB.
DR GO; GO:0042127; P:regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0009611; P:response to wounding; ISS:UniProtKB.
DR GO; GO:0030103; P:vasopressin secretion; IGI:UniProtKB.
DR InterPro; IPR028173; Augurin.
DR PANTHER; PTHR31613; PTHR31613; 1.
DR Pfam; PF15187; Augurin; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cleavage on pair of basic residues; Cytoplasm; Membrane;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..31
FT /evidence="ECO:0000250|UniProtKB:D4A540"
FT PROPEP 32..68
FT /evidence="ECO:0000250|UniProtKB:D4A540"
FT /id="PRO_0000363237"
FT PEPTIDE 71..132
FT /note="Augurin"
FT /id="PRO_0000250514"
FT PROPEP 133..148
FT /evidence="ECO:0000255"
FT /id="PRO_0000363238"
FT VARIANT 52
FT /note="A -> T (in dbSNP:rs10187689)"
FT /id="VAR_050962"
SQ SEQUENCE 148 AA; 17183 MW; 021529FA4BDD863A CRC64;
MAASPARPAV LALTGLALLL LLCWGPGGIS GNKLKLMLQK REAPVPTKTK VAVDENKAKE
FLGSLKRQKR QLWDRTRPEV QQWYQQFLYM GFDEAKFEDD ITYWLNRDRN GHEYYGDYYQ
RHYDEDSAIG PRSPYGFRHG ASVNYDDY
