ID   AUGN_BOVIN              Reviewed;         147 AA.
AC   Q32KM8;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Augurin {ECO:0000305};
DE   Flags: Precursor;
GN   Name=ECRG4 {ECO:0000305};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable hormone that may attenuate cell proliferation and
CC       induce senescence of oligodendrocyte and neural precursor cells in the
CC       central nervous system (By similarity). ECRG4-induced senescence is
CC       characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1
CC       and CCND3 proteasomal degradation (By similarity).
CC       {ECO:0000250|UniProtKB:D4A540}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9H1Z8}.
CC       Cytoplasm {ECO:0000250|UniProtKB:Q9H1Z8}. Apical cell membrane
CC       {ECO:0000250|UniProtKB:Q9H1Z8}.
CC   -!- SIMILARITY: Belongs to the augurin family. {ECO:0000305}.
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DR   EMBL; BC110018; AAI10019.1; -; mRNA.
DR   RefSeq; NP_001033202.1; NM_001038113.2.
DR   AlphaFoldDB; Q32KM8; -.
DR   SMR; Q32KM8; -.
DR   STRING; 9913.ENSBTAP00000016771; -.
DR   PaxDb; Q32KM8; -.
DR   GeneID; 515133; -.
DR   KEGG; bta:515133; -.
DR   CTD; 84417; -.
DR   eggNOG; ENOG502RZPP; Eukaryota.
DR   OrthoDB; 1431738at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR   GO; GO:0090398; P:cellular senescence; IBA:GO_Central.
DR   GO; GO:0007417; P:central nervous system development; ISS:UniProtKB.
DR   GO; GO:0070314; P:G1 to G0 transition; IBA:GO_Central.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0042127; P:regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:0009611; P:response to wounding; ISS:UniProtKB.
DR   InterPro; IPR028173; Augurin.
DR   PANTHER; PTHR31613; PTHR31613; 1.
DR   Pfam; PF15187; Augurin; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cleavage on pair of basic residues; Cytoplasm; Membrane;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000250|UniProtKB:D4A540"
FT   PROPEP          32..68
FT                   /evidence="ECO:0000250|UniProtKB:D4A540"
FT                   /id="PRO_0000446066"
FT   PEPTIDE         71..131
FT                   /note="Augurin"
FT                   /id="PRO_0000250513"
FT   PROPEP          132..147
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000363236"
SQ   SEQUENCE   147 AA;  17101 MW;  ED4F6BB90893E9B1 CRC64;
     MANSSARPAF LVMTALALLL LLCVGPGGIS GNKLKLLLRK REAPAPTMTP VAVQESRAKE
     FLSSLRRPKR QLWDRSRPEV QQWYQHFLYL GFDEAKFEDD ISYWLNRNRN GHDYYDYYQR
     HYDEDSAIGP RSAHSFRHGA SVNYDDY