AUGNB_DANRE
ID AUGNB_DANRE Reviewed; 144 AA.
AC P0CAX4; F1QPI8;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 1.
DT 03-AUG-2022, entry version 36.
DE RecName: Full=Augurin-B {ECO:0000305};
DE AltName: Full=Esophageal cancer-related gene 4-B protein homolog {ECO:0000312|ZFIN:ZDB-GENE-110324-2};
DE Flags: Precursor;
GN Name=ecrg4b {ECO:0000312|ZFIN:ZDB-GENE-110324-2}; ORFNames=im:7256818;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000312|Proteomes:UP000000437};
RN [1] {ECO:0000312|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000312|Proteomes:UP000000437};
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Larva;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable hormone (By similarity). Required for the proper
CC formation of the central nervous system by attenuating cell
CC proliferation during development (By similarity).
CC {ECO:0000250|UniProtKB:D4A540, ECO:0000250|UniProtKB:Q566V9}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9H1Z8}.
CC Cytoplasm {ECO:0000250|UniProtKB:Q9H1Z8}. Apical cell membrane
CC {ECO:0000250|UniProtKB:Q9H1Z8}.
CC -!- SIMILARITY: Belongs to the augurin family. {ECO:0000305}.
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DR EMBL; CU683875; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU855811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC095747; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; P0CAX4; -.
DR STRING; 7955.ENSDARP00000105276; -.
DR PaxDb; P0CAX4; -.
DR PRIDE; P0CAX4; -.
DR ZFIN; ZDB-GENE-110324-2; ecrg4b.
DR eggNOG; ENOG502RZPP; Eukaryota.
DR HOGENOM; CLU_153579_0_0_1; -.
DR InParanoid; P0CAX4; -.
DR OrthoDB; 1431738at2759; -.
DR PhylomeDB; P0CAX4; -.
DR TreeFam; TF336161; -.
DR PRO; PR:P0CAX4; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR GO; GO:0090398; P:cellular senescence; IBA:GO_Central.
DR GO; GO:0007417; P:central nervous system development; ISS:UniProtKB.
DR GO; GO:0070314; P:G1 to G0 transition; IBA:GO_Central.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0042127; P:regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0009611; P:response to wounding; ISS:UniProtKB.
DR InterPro; IPR028173; Augurin.
DR PANTHER; PTHR31613; PTHR31613; 1.
DR Pfam; PF15187; Augurin; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cleavage on pair of basic residues; Cytoplasm; Membrane;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT PROPEP 19..68
FT /evidence="ECO:0000250|UniProtKB:D4A540"
FT /id="PRO_0000446068"
FT CHAIN 71..144
FT /note="Augurin-B"
FT /id="PRO_0000378334"
FT REGION 109..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 10
FT /note="T -> A (in Ref. 2; BC095747)"
FT /evidence="ECO:0000305"
FT CONFLICT 22
FT /note="S -> P (in Ref. 2; BC095747)"
FT /evidence="ECO:0000305"
FT CONFLICT 44
FT /note="E -> D (in Ref. 2; BC095747)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 144 AA; 16872 MW; 954E68091E8B0BD9 CRC64;
MSLHSLCVPT ILLISVLSIC LSSGGSSDSK LHRILIKRDA KEIESRPKAY ISVQQSKAKE
FLSGLHRTKR NVWDRSRPDV QQWIQQFMYM GYDEARLETD LSYWMDQARS NDQGRQHHHD
ENAPMSQQDP RYNRHGANVN YDYY
