AUF2_ARATH
ID AUF2_ARATH Reviewed; 314 AA.
AC Q9LM18;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=F-box protein AUF2 {ECO:0000305};
DE AltName: Full=F-box protein At1g22220 {ECO:0000305};
DE AltName: Full=Protein AUXIN UP-REGULATED F-BOX PROTEIN 2 {ECO:0000303|PubMed:21653785};
GN Name=AUF2 {ECO:0000303|PubMed:21653785};
GN OrderedLocusNames=At1g22220 {ECO:0000312|Araport:AT1G22220};
GN ORFNames=F16L1.5 {ECO:0000312|EMBL:AAF87851.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Carninci P., Hayashizaki Y.,
RA Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M.,
RA Shinozaki K., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP INDUCTION.
RX PubMed=21653785; DOI=10.1104/pp.111.179812;
RA Zheng X., Miller N.D., Lewis D.R., Christians M.J., Lee K.H., Muday G.K.,
RA Spalding E.P., Vierstra R.D.;
RT "AUXIN UP-REGULATED F-BOX PROTEIN1 regulates the cross talk between auxin
RT transport and cytokinin signaling during plant root growth.";
RL Plant Physiol. 156:1878-1893(2011).
CC -!- FUNCTION: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase
CC complexes, which may mediate the ubiquitination and subsequent
CC proteasomal degradation of target proteins.
CC {ECO:0000250|UniProtKB:Q9SRV0}.
CC -!- PATHWAY: Protein modification; protein ubiquitination. {ECO:0000305}.
CC -!- SUBUNIT: Part of a SCF (ASK-cullin-F-box) protein ligase complex.
CC {ECO:0000250|UniProtKB:Q8LEA8}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8LEA8}.
CC -!- INDUCTION: Not induced by auxin. {ECO:0000269|PubMed:21653785}.
CC -!- DOMAIN: The F-box is necessary for the interaction with ASK proteins.
CC {ECO:0000250|UniProtKB:Q8LEA8}.
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DR EMBL; AC073942; AAF87851.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE30213.1; -; Genomic_DNA.
DR EMBL; BT012651; AAT06470.1; -; mRNA.
DR EMBL; AK176237; BAD44000.1; -; mRNA.
DR PIR; H86354; H86354.
DR RefSeq; NP_173641.1; NM_102072.4.
DR AlphaFoldDB; Q9LM18; -.
DR BioGRID; 24066; 7.
DR IntAct; Q9LM18; 1.
DR STRING; 3702.AT1G22220.1; -.
DR PaxDb; Q9LM18; -.
DR PRIDE; Q9LM18; -.
DR EnsemblPlants; AT1G22220.1; AT1G22220.1; AT1G22220.
DR GeneID; 838827; -.
DR Gramene; AT1G22220.1; AT1G22220.1; AT1G22220.
DR KEGG; ath:AT1G22220; -.
DR Araport; AT1G22220; -.
DR TAIR; locus:2015046; AT1G22220.
DR eggNOG; ENOG502QV7H; Eukaryota.
DR HOGENOM; CLU_049279_2_0_1; -.
DR InParanoid; Q9LM18; -.
DR OMA; SSRHYLM; -.
DR OrthoDB; 988686at2759; -.
DR PhylomeDB; Q9LM18; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q9LM18; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9LM18; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR GO; GO:0071456; P:cellular response to hypoxia; HEP:TAIR.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR InterPro; IPR044809; AUF1-like.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR PANTHER; PTHR31215; PTHR31215; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..314
FT /note="F-box protein AUF2"
FT /id="PRO_0000283569"
FT DOMAIN 1..49
FT /note="F-box"
SQ SEQUENCE 314 AA; 34499 MW; F94345E0872D323D CRC64;
MDVFDGLPDP IIVDILNKVG DVKTLLRCSS LSKRFNSLVP QSESLTLRLD HSVSDSPVVT
SIFRSLFNGL VSLLSKPAKP ITITTLSPSL PFKILSRFDR IRNLDVELPG GDVKLEKGAA
VKWKAEFGKT LKSCVIVAFR SAGTVSSPVA VEGESDAEFV TGLKTRVVWT ISALMAASSR
HYLMREVVKE HEEIESLVMR DKEREGTVVM NEEGLKELRN TEARVEDEER VVKNKRSVVP
SVRMSMRHAP SLKLKSGICL ESATLVIVRP SGADFEVGDD AELATEAFVG DCMYGEAVVA
LLKCKKNALE MNSF
