ATZ1_CAEEL
ID ATZ1_CAEEL Reviewed; 268 AA.
AC Q19872;
DT 02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Protein atz-1 {ECO:0000305};
DE AltName: Full=Abnormal transition zone 1 {ECO:0000303|PubMed:28696027, ECO:0000312|WormBase:F28D1.2};
GN Name=atz-1 {ECO:0000303|PubMed:28696027, ECO:0000312|WormBase:F28D1.2};
GN ORFNames=F28D1.2 {ECO:0000312|WormBase:F28D1.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=28696027; DOI=10.1002/cbin.10821;
RA Dawson J.A., Methven-Kelley C., Davis G.M.;
RT "atz-1 Influences meiosis to maintain germline chromosomal stability in
RT Caenorhabditis elegans.";
RL Cell Biol. Int. 41:1160-1168(2017).
CC -!- FUNCTION: Plays a role in meiosis, germline development and oocyte
CC morphogenesis (PubMed:28696027). May play a role in DNA replication
CC (PubMed:28696027). In the germline, involved in the maintenance of
CC transition zone nuclei and in chromosome structure and organization,
CC but not required for mitotic proliferation (PubMed:28696027).
CC {ECO:0000269|PubMed:28696027}.
CC -!- INTERACTION:
CC Q19872; Q9TZK8: meg-4; NbExp=3; IntAct=EBI-316637, EBI-314126;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28696027}.
CC -!- DEVELOPMENTAL STAGE: Expressed in embryos.
CC {ECO:0000269|PubMed:28696027}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in embryonic
CC lethality in 10% of animals (PubMed:28696027). Surviving animals have a
CC reduced brood size and abnormal diakinetic oocyte morphology
CC (PubMed:28696027). {ECO:0000269|PubMed:28696027}.
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DR EMBL; BX284604; CAA94596.1; -; Genomic_DNA.
DR PIR; T21492; T21492.
DR RefSeq; NP_502359.1; NM_069958.5.
DR AlphaFoldDB; Q19872; -.
DR SMR; Q19872; -.
DR DIP; DIP-25650N; -.
DR IntAct; Q19872; 18.
DR STRING; 6239.F28D1.2; -.
DR EPD; Q19872; -.
DR PaxDb; Q19872; -.
DR PeptideAtlas; Q19872; -.
DR EnsemblMetazoa; F28D1.2.1; F28D1.2.1; WBGene00009212.
DR GeneID; 178186; -.
DR KEGG; cel:CELE_F28D1.2; -.
DR UCSC; F28D1.2; c. elegans.
DR CTD; 178186; -.
DR WormBase; F28D1.2; CE05742; WBGene00009212; atz-1.
DR eggNOG; ENOG502TIV3; Eukaryota.
DR HOGENOM; CLU_928254_0_0_1; -.
DR InParanoid; Q19872; -.
DR OMA; ICEMSKE; -.
DR OrthoDB; 1856257at2759; -.
DR PhylomeDB; Q19872; -.
DR SignaLink; Q19872; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00009212; Expressed in embryo and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0048601; P:oocyte morphogenesis; IMP:UniProtKB.
DR GO; GO:0090727; P:positive regulation of brood size; IMP:UniProtKB.
DR GO; GO:2001252; P:positive regulation of chromosome organization; IMP:UniProtKB.
DR GO; GO:0045740; P:positive regulation of DNA replication; IMP:UniProtKB.
DR GO; GO:0045836; P:positive regulation of meiotic nuclear division; IMP:UniProtKB.
PE 1: Evidence at protein level;
KW Coiled coil; DNA replication; Meiosis; Nucleus; Reference proteome.
FT CHAIN 1..268
FT /note="Protein atz-1"
FT /id="PRO_0000453042"
FT REGION 229..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 171..243
FT /evidence="ECO:0000255"
FT COMPBIAS 233..268
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 268 AA; 31196 MW; 720A2C4A2B43A5E8 CRC64;
MASIELRNVQ TELAAKNLQF KVLTEKFLEQ RKELFDAKKT DSNVEYVECL SEKLRVATER
ISDLEKETKE GKQVANEEIG RLEKLLREAQ QKRDAKIDES YQTFLRIELL VANLGESTDP
ENEKRIKNLM PAAKTGIPPE GVLRLTINAL DSAARESKKK TMAIESLTKQ VDDANKLTEV
YMKRLEELED KHRFEEALTL KIQAMMIETT GQLEAQKKII ADLQKKNDDL MKEEEGEEDY
EEEENYEVEE DFEDEEEYDE EGEEEDYE
