ID   RPN4_CANAL              Reviewed;         536 AA.
AC   Q59VM4; A0A1D8PD90;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Transcriptional regulator RPN4;
GN   Name=RPN4; OrderedLocusNames=CAALFM_C104330WA; ORFNames=CaO19.1069;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   FUNCTION, AND DNA-BINDING.
RX   PubMed=15534694; DOI=10.1371/journal.pbio.0020398;
RA   Gasch A.P., Moses A.M., Chiang D.Y., Fraser H.B., Berardini M., Eisen M.B.;
RT   "Conservation and evolution of cis-regulatory systems in ascomycete
RT   fungi.";
RL   PLoS Biol. 2:E398-E398(2004).
RN   [5]
RP   INDUCTION.
RX   PubMed=16339080; DOI=10.1091/mbc.e05-06-0501;
RA   Enjalbert B., Smith D.A., Cornell M.J., Alam I., Nicholls S., Brown A.J.P.,
RA   Quinn J.;
RT   "Role of the Hog1 stress-activated protein kinase in the global
RT   transcriptional response to stress in the fungal pathogen Candida
RT   albicans.";
RL   Mol. Biol. Cell 17:1018-1032(2006).
RN   [6]
RP   INDUCTION.
RX   PubMed=21592964; DOI=10.1074/jbc.m111.233569;
RA   Singh R.P., Prasad H.K., Sinha I., Agarwal N., Natarajan K.;
RT   "Cap2-HAP complex is a critical transcriptional regulator that has dual but
RT   contrasting roles in regulation of iron homeostasis in Candida albicans.";
RL   J. Biol. Chem. 286:25154-25170(2011).
RN   [7]
RP   INDUCTION.
RX   PubMed=22265407; DOI=10.1016/j.cell.2011.10.048;
RA   Nobile C.J., Fox E.P., Nett J.E., Sorrells T.R., Mitrovich Q.M.,
RA   Hernday A.D., Tuch B.B., Andes D.R., Johnson A.D.;
RT   "A recently evolved transcriptional network controls biofilm development in
RT   Candida albicans.";
RL   Cell 148:126-138(2012).
CC   -!- FUNCTION: Transcriptional activator of a number of genes encoding
CC       proteasomal subunits. Binds to the DNA sequence 5'-GAAGGCAAAA-3',
CC       enriched in regions upstream of proteasome genes.
CC       {ECO:0000269|PubMed:15534694}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- INDUCTION: Expression is induced by HAP43, by osmotic stress, by
CC       oxidative stress, by heavy metal stress, and during biofilm formation.
CC       {ECO:0000269|PubMed:16339080, ECO:0000269|PubMed:21592964,
CC       ECO:0000269|PubMed:22265407}.
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DR   EMBL; CP017623; AOW26107.1; -; Genomic_DNA.
DR   RefSeq; XP_713673.1; XM_708580.2.
DR   AlphaFoldDB; Q59VM4; -.
DR   STRING; 237561.Q59VM4; -.
DR   GeneID; 3644684; -.
DR   KEGG; cal:CAALFM_C104330WA; -.
DR   CGD; CAL0000195107; RPN4.
DR   VEuPathDB; FungiDB:C1_04330W_A; -.
DR   eggNOG; ENOG502RBAK; Eukaryota.
DR   HOGENOM; CLU_024993_0_0_1; -.
DR   InParanoid; Q59VM4; -.
DR   OMA; DDDNYFQ; -.
DR   OrthoDB; 1361991at2759; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:CGD.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:CGD.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; ISS:CGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:CGD.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW   Stress response; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..536
FT                   /note="Transcriptional regulator RPN4"
FT                   /id="PRO_0000426064"
FT   ZN_FING         440..471
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          154..196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          353..375
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          393..434
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        154..187
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        393..411
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        412..434
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   536 AA;  60153 MW;  FCB82332A4C8F715 CRC64;
     MTSLAILPQL KRTITDIMDE ELYQSPSSPN SMTSFPSGTG NLMSNTNHNT FNQSNNTPFN
     MNYNHISNRN SINSSPNLSA TTFNNANNLG NVLNIPDSFL EQLASQDYID HLKSQQQQEQ
     AFENPDDIYV QDVHENQVNP FNDYGNPDSF IRAQEQQSQL PQPQQPISQQ DKQRPQSQQQ
     QATKAPLPQA FPTRRRRKIT LLNDIGGSST RKKHFDEDYL LYNPDISPGH IVTDCSLDSS
     LVIPPNSNEL FLTESESPEF ANDIIPGYEN DYLFLDDDDE QIEEDVSDDE GDNYFQVDED
     FDDYLMNNNG YDGYPTFNNY ESSGNNTDII NNNNNIVDET ISDANSNSEL EVVFDQPKEV
     SPSAISPASP DSDDMMIDVE DETEIADATA AKEEINKKHS KSGKKESKSQ KENQLTTTTK
     SKKHSHGISG AEITLNNPNH QCNLINPSTG EPCNKQFSRP YDLIRHQDTI HASMKKIFRC
     VICEGRLNGG PGNGKEKTFS RGDALSRHIK IKHGLVGQDA LDLINEAKEN VEYIPV