ID   RPC3_DICDI              Reviewed;         666 AA.
AC   Q55FJ5;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=DNA-directed RNA polymerase III subunit rpc3;
DE            Short=RNA polymerase III subunit C3;
DE   AltName: Full=DNA-directed RNA polymerase III subunit C;
GN   Name=polr3c; Synonyms=rpc3; ORFNames=DDB_G0268080;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Specific core component of RNA polymerase III which synthesizes small
CC       RNAs, such as 5S rRNA and tRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC       consisting of 17 subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the eukaryotic RPC3/POLR3C RNA polymerase
CC       subunit family. {ECO:0000305}.
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DR   EMBL; AAFI02000003; EAL73493.1; -; Genomic_DNA.
DR   RefSeq; XP_647538.1; XM_642446.1.
DR   AlphaFoldDB; Q55FJ5; -.
DR   SMR; Q55FJ5; -.
DR   STRING; 44689.DDB0216314; -.
DR   PaxDb; Q55FJ5; -.
DR   EnsemblProtists; EAL73493; EAL73493; DDB_G0268080.
DR   GeneID; 8616345; -.
DR   KEGG; ddi:DDB_G0268080; -.
DR   dictyBase; DDB_G0268080; rpc3.
DR   eggNOG; KOG2587; Eukaryota.
DR   HOGENOM; CLU_023294_1_1_1; -.
DR   InParanoid; Q55FJ5; -.
DR   OMA; NPAFTFF; -.
DR   PhylomeDB; Q55FJ5; -.
DR   Reactome; R-DDI-76061; RNA Polymerase III Transcription Initiation From Type 1 Promoter.
DR   Reactome; R-DDI-76066; RNA Polymerase III Transcription Initiation From Type 2 Promoter.
DR   PRO; PR:Q55FJ5; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0005666; C:RNA polymerase III complex; ISS:dictyBase.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 4.
DR   InterPro; IPR013197; RNA_pol_III_RPC82-rel_HTH.
DR   InterPro; IPR039748; RPC3.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR12949; PTHR12949; 2.
DR   Pfam; PF08221; HTH_9; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleus; Reference proteome; Transcription.
FT   CHAIN           1..666
FT                   /note="DNA-directed RNA polymerase III subunit rpc3"
FT                   /id="PRO_0000330756"
FT   REGION          179..228
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          250..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          320..371
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        250..289
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   666 AA;  75335 MW;  A83E5E6463D700AF CRC64;
     MYEQKVAIDI VKESFGDDVT KVFEFLVQRG KSSYKIINQS LSGKGGLTIK RIKQCLLVLI
     QHNLVTYEEF LLPLTKDEIE KLVPGEPLPS DSVYEAIIVN AIHRLRFPKF INYIKHSKGD
     EAAYILEELI DHGRLPMDLL IKQASQIQRV DTFEDQDDIT KRFEDTFTKL IMDQFIMRAP
     RPRPVSDQET SNALSKEAKK VGGGGANGNN VGAHQKKDSD PFALPSVGFS SNGPLSSVDN
     SANDAESLEI LTGKSSTTTI PSQPKKGTAK KTSAKPKSTA INTTATASLG RKRKSRDIYD
     EDDDEEPDLL VIEENVEINV NDHNSANKNS TTTTTTTTTK TGQHTLKKSK LDQSSSTTTT
     SSRQQQNGMD QQRIIDESRV LWTINYEQFI IEFKLKACYD FVTEKNNQQS GLLFNAMVKL
     CKRSIRSNQD SLTSCVYGEN ILEEYNRDLD SSKKMDKLQI EKYLSIMQAS RPSMVTKMVS
     KSKQSSSSEL GAYQVNVGNI IGIIKQKMVE SIIKQKFGDN GLRVFKLLLI KNLLEPKQIA
     ELAMIPPNEC KALLFNMMQK NIIRLQEIPR SSDHFANRTF YLFFVDLPTI IATFTEDIFK
     AIYNTRERLK SELEPHKDAL EKLTQLDEDQ ITEDQAKIYK KTDRITQTLL TVILNLDNDL
     LHLYSF