ID   RNH2B_XENTR             Reviewed;         306 AA.
AC   Q28GD9; Q0IIW0;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Ribonuclease H2 subunit B;
DE            Short=RNase H2 subunit B;
DE   AltName: Full=Ribonuclease HI subunit B;
GN   Name=rnaseh2b; ORFNames=TEgg013b21.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Oviduct;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Non catalytic subunit of RNase H2, an endonuclease that
CC       specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA
CC       replication, possibly by mediating the removal of lagging-strand
CC       Okazaki fragment RNA primers during DNA replication. Mediates the
CC       excision of single ribonucleotides from DNA:RNA duplexes (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The RNase H2 complex is a heterotrimer composed of the
CC       catalytic subunit rnaseh2a and the non-catalytic subunits rnaseh2b and
CC       rnaseh2c. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNase H2 subunit B family. {ECO:0000305}.
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DR   EMBL; CR761427; CAJ82251.1; -; mRNA.
DR   EMBL; BC121543; AAI21544.1; -; mRNA.
DR   RefSeq; NP_001016329.1; NM_001016329.2.
DR   AlphaFoldDB; Q28GD9; -.
DR   SMR; Q28GD9; -.
DR   STRING; 8364.ENSXETP00000037200; -.
DR   PaxDb; Q28GD9; -.
DR   DNASU; 549083; -.
DR   GeneID; 549083; -.
DR   KEGG; xtr:549083; -.
DR   CTD; 79621; -.
DR   Xenbase; XB-GENE-1004443; rnaseh2b.
DR   eggNOG; KOG4705; Eukaryota.
DR   HOGENOM; CLU_059802_0_0_1; -.
DR   InParanoid; Q28GD9; -.
DR   OrthoDB; 1092212at2759; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000020720; Expressed in testis and 14 other tissues.
DR   ExpressionAtlas; Q28GD9; baseline.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0032299; C:ribonuclease H2 complex; ISS:UniProtKB.
DR   GO; GO:0009259; P:ribonucleotide metabolic process; IBA:GO_Central.
DR   GO; GO:0006401; P:RNA catabolic process; ISS:UniProtKB.
DR   CDD; cd09270; RNase_H2-B; 1.
DR   InterPro; IPR040456; RNase_H2_suB.
DR   InterPro; IPR019024; RNase_H2_suB_wHTH.
DR   InterPro; IPR041195; Rnh202_N.
DR   PANTHER; PTHR13383; PTHR13383; 1.
DR   Pfam; PF09468; RNase_H2-Ydr279; 1.
DR   Pfam; PF17745; Ydr279_N; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..306
FT                   /note="Ribonuclease H2 subunit B"
FT                   /id="PRO_0000248382"
FT   REGION          232..285
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        244..269
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   306 AA;  34447 MW;  F73C73905F7DF6A9 CRC64;
     MVSRRQRPGS GQSEQWVLLA PESLSDDAKN LSDKTIFAKL RAPCTDKGSM FLFIDSGQQI
     CEVKAFHEEY RSWFIGQTVQ QDGRLLIATP IDPMFLVLHY LIKADKEQGK FQPVEQIVVD
     EEFPSCSMLL QCTPVSKSLH HVTEEKEIGS KKFYKYSKEK TLVWLKKKVE LTVKVLKSSN
     ICVGGGVQSA TFIRNTQGSD VKEEDYTRYA HGLISEYLTE DLREDLSKYL GLPDLSSPTP
     EPPVKKRKVS EAPVEAEEDY TKFNSDSKNK KSNSKMTAAQ KSLAKVDKSG MKNISAFFSP
     KAKATK