ID   RNH2B_BOVIN             Reviewed;         309 AA.
AC   Q3ZBI3;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 2.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Ribonuclease H2 subunit B;
DE            Short=RNase H2 subunit B;
DE   AltName: Full=Ribonuclease HI subunit B;
GN   Name=RNASEH2B;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Non catalytic subunit of RNase H2, an endonuclease that
CC       specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA
CC       replication, possibly by mediating the removal of lagging-strand
CC       Okazaki fragment RNA primers during DNA replication. Mediates the
CC       excision of single ribonucleotides from DNA:RNA duplexes (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The RNase H2 complex is a heterotrimer composed of the
CC       catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and
CC       RNASEH2C. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNase H2 subunit B family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI03281.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC103280; AAI03281.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001160038.1; NM_001166566.1.
DR   AlphaFoldDB; Q3ZBI3; -.
DR   SMR; Q3ZBI3; -.
DR   STRING; 9913.ENSBTAP00000026838; -.
DR   PaxDb; Q3ZBI3; -.
DR   PRIDE; Q3ZBI3; -.
DR   Ensembl; ENSBTAT00000026838; ENSBTAP00000026838; ENSBTAG00000020149.
DR   GeneID; 509258; -.
DR   KEGG; bta:509258; -.
DR   CTD; 79621; -.
DR   VEuPathDB; HostDB:ENSBTAG00000020149; -.
DR   VGNC; VGNC:107254; RNASEH2B.
DR   eggNOG; KOG4705; Eukaryota.
DR   GeneTree; ENSGT00390000011439; -.
DR   HOGENOM; CLU_059802_0_0_1; -.
DR   InParanoid; Q3ZBI3; -.
DR   OMA; MACDIVG; -.
DR   OrthoDB; 1092212at2759; -.
DR   TreeFam; TF105250; -.
DR   Proteomes; UP000009136; Chromosome 12.
DR   Bgee; ENSBTAG00000020149; Expressed in thymus and 106 other tissues.
DR   ExpressionAtlas; Q3ZBI3; baseline and differential.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0032299; C:ribonuclease H2 complex; ISS:UniProtKB.
DR   GO; GO:0009259; P:ribonucleotide metabolic process; IBA:GO_Central.
DR   GO; GO:0006401; P:RNA catabolic process; ISS:UniProtKB.
DR   CDD; cd09270; RNase_H2-B; 1.
DR   InterPro; IPR040456; RNase_H2_suB.
DR   InterPro; IPR019024; RNase_H2_suB_wHTH.
DR   InterPro; IPR041195; Rnh202_N.
DR   PANTHER; PTHR13383; PTHR13383; 1.
DR   Pfam; PF09468; RNase_H2-Ydr279; 1.
DR   Pfam; PF17745; Ydr279_N; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Nucleus; Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q5TBB1"
FT   CHAIN           2..309
FT                   /note="Ribonuclease H2 subunit B"
FT                   /id="PRO_0000248377"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5TBB1"
FT   MOD_RES         295
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5TBB1"
FT   MOD_RES         296
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5TBB1"
SQ   SEQUENCE   309 AA;  35008 MW;  3B31765CBFDD6B8F CRC64;
     MARGADGGDG ASVWQHVFLL PEYLKDDSKK MKSGLVFVKL ANPCSGEGTI YLFNMCLPQL
     FEIKVFKEKN HSWFINESVQ SGGLLHFATP VDPLFLLLHY LIKADKESFQ GKFQPLDQVV
     MDDMFPDCIL LLKLPELEKL LQHVTEEKEV DKKKYYKYSK EKTLKWLGKK VNQTMAALKT
     NKVNVSARVQ STAFFSGGQV SSDKDEDYVR YAHGLISDYI PKQLSDDLSK YLKLPEPPAS
     VRNPPSKKAK LSDEPVMAKE DYTKFNSKDF KTVKKNSKMT AAQKALAKVD KSGMKSIDSF
     FGTKHVKKK