RM52_MOUSE
ID RM52_MOUSE Reviewed; 121 AA.
AC Q9D0Y8; Q6PAU6;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=39S ribosomal protein L52, mitochondrial;
DE Short=L52mt;
DE Short=MRP-L52;
DE Flags: Precursor;
GN Name=Mrpl52;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC which comprises a 16S rRNA and about 50 distinct proteins.
CC {ECO:0000250|UniProtKB:Q86TS9}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q86TS9}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D0Y8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D0Y8-2; Sequence=VSP_022476;
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mL52 family. {ECO:0000305}.
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DR EMBL; AK004194; BAB23216.1; -; mRNA.
DR EMBL; AK150806; BAE29869.1; -; mRNA.
DR EMBL; AK151615; BAE30552.1; -; mRNA.
DR EMBL; AK152876; BAE31561.1; -; mRNA.
DR EMBL; AK164629; BAE37850.1; -; mRNA.
DR EMBL; BC028522; AAH28522.1; -; mRNA.
DR EMBL; BC060043; AAH60043.1; -; mRNA.
DR CCDS; CCDS27088.1; -. [Q9D0Y8-1]
DR RefSeq; NP_081127.1; NM_026851.2. [Q9D0Y8-1]
DR AlphaFoldDB; Q9D0Y8; -.
DR SMR; Q9D0Y8; -.
DR ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit.
DR STRING; 10090.ENSMUSP00000010550; -.
DR iPTMnet; Q9D0Y8; -.
DR PhosphoSitePlus; Q9D0Y8; -.
DR EPD; Q9D0Y8; -.
DR MaxQB; Q9D0Y8; -.
DR PaxDb; Q9D0Y8; -.
DR PeptideAtlas; Q9D0Y8; -.
DR PRIDE; Q9D0Y8; -.
DR ProteomicsDB; 300406; -. [Q9D0Y8-1]
DR ProteomicsDB; 300407; -. [Q9D0Y8-2]
DR Antibodypedia; 194; 70 antibodies from 22 providers.
DR DNASU; 68836; -.
DR Ensembl; ENSMUST00000010550; ENSMUSP00000010550; ENSMUSG00000010406. [Q9D0Y8-1]
DR Ensembl; ENSMUST00000199195; ENSMUSP00000142555; ENSMUSG00000010406. [Q9D0Y8-2]
DR GeneID; 68836; -.
DR KEGG; mmu:68836; -.
DR UCSC; uc007tvz.1; mouse. [Q9D0Y8-1]
DR CTD; 122704; -.
DR MGI; MGI:1916086; Mrpl52.
DR VEuPathDB; HostDB:ENSMUSG00000010406; -.
DR eggNOG; ENOG502S4I0; Eukaryota.
DR GeneTree; ENSGT00390000005763; -.
DR HOGENOM; CLU_135844_0_0_1; -.
DR InParanoid; Q9D0Y8; -.
DR OMA; PLGANQK; -.
DR OrthoDB; 1623574at2759; -.
DR PhylomeDB; Q9D0Y8; -.
DR TreeFam; TF323872; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 68836; 22 hits in 75 CRISPR screens.
DR ChiTaRS; Mrpl52; mouse.
DR PRO; PR:Q9D0Y8; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q9D0Y8; protein.
DR Bgee; ENSMUSG00000010406; Expressed in floor plate of midbrain and 262 other tissues.
DR ExpressionAtlas; Q9D0Y8; baseline and differential.
DR Genevisible; Q9D0Y8; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0003735; F:structural constituent of ribosome; ISS:UniProtKB.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR GO; GO:0006412; P:translation; ISS:UniProtKB.
DR InterPro; IPR034596; MRPL52.
DR PANTHER; PTHR34090; PTHR34090; 1.
DR Pfam; PF18699; MRPL52; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Mitochondrion; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein; Transit peptide.
FT TRANSIT 1..22
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 23..121
FT /note="39S ribosomal protein L52, mitochondrial"
FT /id="PRO_0000273094"
FT REGION 98..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..58
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022476"
SQ SEQUENCE 121 AA; 13658 MW; C024F28F8A5B016A CRC64;
MAALGTWLSS VRRLHCSVVA RAGGQWRLQQ GLAANPSGYG PLTELPDWSF ADGRPAPPMK
GQLRRKAQRE KLARRVVLLT QEMDAGIQAW KLRQQKLQEE RKKEHDLKPK GTLLRSPLPN
Q
