RM42_MOUSE
ID RM42_MOUSE Reviewed; 142 AA.
AC Q9CPV3;
DT 19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=39S ribosomal protein L42, mitochondrial;
DE Short=L42mt;
DE Short=MRP-L42;
DE AltName: Full=28S ribosomal protein S32, mitochondrial;
DE Short=MRP-S32;
DE Short=S32mt;
DE AltName: Full=39S ribosomal protein L31, mitochondrial;
DE Short=L31mt;
DE Short=MRP-L31;
DE Flags: Precursor;
GN Name=Mrpl42; Synonyms=D10Ertd322e, Mrps32;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, Hippocampus, and Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC which comprises a 16S rRNA and about 50 distinct proteins. Component of
CC the mitochondrial ribosome small subunit (28S) which comprises a 12S
CC rRNA and about 30 distinct proteins. {ECO:0000250|UniProtKB:Q9Y6G3}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9Y6G3}.
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mL42 family. {ECO:0000305}.
CC -!- CAUTION: Has been found in the mitochondrial ribosome large and small
CC subunits. {ECO:0000305}.
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DR EMBL; AK013693; BAB28957.1; -; mRNA.
DR EMBL; AK002530; BAB22166.1; -; mRNA.
DR EMBL; AK003427; BAB22785.1; -; mRNA.
DR EMBL; BC024337; AAH24337.1; -; mRNA.
DR CCDS; CCDS24137.1; -.
DR RefSeq; NP_080341.1; NM_026065.3.
DR RefSeq; XP_006514042.1; XM_006513979.3.
DR AlphaFoldDB; Q9CPV3; -.
DR SMR; Q9CPV3; -.
DR ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit.
DR STRING; 10090.ENSMUSP00000075226; -.
DR PhosphoSitePlus; Q9CPV3; -.
DR EPD; Q9CPV3; -.
DR MaxQB; Q9CPV3; -.
DR PaxDb; Q9CPV3; -.
DR PeptideAtlas; Q9CPV3; -.
DR PRIDE; Q9CPV3; -.
DR ProteomicsDB; 260981; -.
DR Antibodypedia; 30057; 214 antibodies from 21 providers.
DR DNASU; 67270; -.
DR Ensembl; ENSMUST00000075829; ENSMUSP00000075226; ENSMUSG00000062981.
DR Ensembl; ENSMUST00000218893; ENSMUSP00000151636; ENSMUSG00000062981.
DR GeneID; 67270; -.
DR KEGG; mmu:67270; -.
DR UCSC; uc007gwi.1; mouse.
DR CTD; 28977; -.
DR MGI; MGI:1333774; Mrpl42.
DR VEuPathDB; HostDB:ENSMUSG00000062981; -.
DR eggNOG; KOG4106; Eukaryota.
DR GeneTree; ENSGT00390000010491; -.
DR HOGENOM; CLU_142926_1_0_1; -.
DR InParanoid; Q9CPV3; -.
DR OMA; MQLTHTT; -.
DR OrthoDB; 1604174at2759; -.
DR PhylomeDB; Q9CPV3; -.
DR TreeFam; TF324368; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 67270; 20 hits in 75 CRISPR screens.
DR ChiTaRS; Mrpl42; mouse.
DR PRO; PR:Q9CPV3; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q9CPV3; protein.
DR Bgee; ENSMUSG00000062981; Expressed in quadriceps femoris and 64 other tissues.
DR ExpressionAtlas; Q9CPV3; baseline and differential.
DR Genevisible; Q9CPV3; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005763; C:mitochondrial small ribosomal subunit; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR InterPro; IPR019346; MRPL42.
DR PANTHER; PTHR13450; PTHR13450; 1.
DR Pfam; PF10210; MRP-S32; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW Transit peptide.
FT TRANSIT 1..31
FT /note="Mitochondrion"
FT /evidence="ECO:0000250"
FT CHAIN 32..142
FT /note="39S ribosomal protein L42, mitochondrial"
FT /id="PRO_0000087725"
SQ SEQUENCE 142 AA; 16493 MW; F2F7FC2E5181AAD5 CRC64;
MAAAVKWAIS NRTIWKHLLP IQNGALSSAC HKSTYSSLPD DYNCQVDLAL TADGRTIVCY
HPSVDIPYEH TKPIPQPDLL HNNEETHEQI LKAKLEVRKS KQLEQGPMIE QLSKVFYTTK
HRWYPHGQYH NRRKKLNPPR DR
