ID   RM22_BOVIN              Reviewed;         204 AA.
AC   Q3SZX5;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=39S ribosomal protein L22, mitochondrial;
DE            Short=L22mt;
DE            Short=MRP-L22;
DE   Flags: Precursor;
GN   Name=MRPL22;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, AND SUBUNIT.
RX   PubMed=11279069; DOI=10.1074/jbc.m100432200;
RA   Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A.,
RA   Watanabe K.;
RT   "Structural compensation for the deficit of rRNA with proteins in the
RT   mammalian mitochondrial ribosome. Systematic analysis of protein components
RT   of the large ribosomal subunit from mammalian mitochondria.";
RL   J. Biol. Chem. 276:21724-21736(2001).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX   PubMed=11551941; DOI=10.1074/jbc.m106510200;
RA   Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M.,
RA   Moseley A., Spremulli L.L.;
RT   "The large subunit of the mammalian mitochondrial ribosome. Analysis of the
RT   complement of ribosomal proteins present.";
RL   J. Biol. Chem. 276:43958-43969(2001).
RN   [4]
RP   STRUCTURE BY ELECTRON MICROSCOPY (12 ANGSTROMS), AND SUBCELLULAR LOCATION.
RX   PubMed=16510155; DOI=10.1016/j.jmb.2006.01.094;
RA   Mears J.A., Sharma M.R., Gutell R.R., McCook A.S., Richardson P.E.,
RA   Caulfield T.R., Agrawal R.K., Harvey S.C.;
RT   "A structural model for the large subunit of the mammalian mitochondrial
RT   ribosome.";
RL   J. Mol. Biol. 358:193-212(2006).
CC   -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC       which comprises a 16S rRNA and about 50 distinct proteins.
CC       {ECO:0000269|PubMed:11279069}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11279069,
CC       ECO:0000269|PubMed:11551941, ECO:0000269|PubMed:16510155}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL22 family.
CC       {ECO:0000305}.
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DR   EMBL; BC102665; AAI02666.1; -; mRNA.
DR   RefSeq; NP_001030531.1; NM_001035454.2.
DR   PDB; 2FTC; EM; -; M=67-176.
DR   PDB; 3IY9; EM; 14.10 A; M=67-176.
DR   PDBsum; 2FTC; -.
DR   PDBsum; 3IY9; -.
DR   AlphaFoldDB; Q3SZX5; -.
DR   SMR; Q3SZX5; -.
DR   IntAct; Q3SZX5; 1.
DR   STRING; 9913.ENSBTAP00000040453; -.
DR   PaxDb; Q3SZX5; -.
DR   PRIDE; Q3SZX5; -.
DR   Ensembl; ENSBTAT00000042844; ENSBTAP00000040453; ENSBTAG00000019457.
DR   GeneID; 614639; -.
DR   KEGG; bta:614639; -.
DR   CTD; 29093; -.
DR   VEuPathDB; HostDB:ENSBTAG00000019457; -.
DR   VGNC; VGNC:31626; MRPL22.
DR   eggNOG; KOG1711; Eukaryota.
DR   GeneTree; ENSGT00390000002110; -.
DR   HOGENOM; CLU_100005_1_0_1; -.
DR   InParanoid; Q3SZX5; -.
DR   OMA; HKVIRQM; -.
DR   OrthoDB; 1054896at2759; -.
DR   TreeFam; TF315111; -.
DR   EvolutionaryTrace; Q3SZX5; -.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000019457; Expressed in oocyte and 106 other tissues.
DR   GO; GO:0015934; C:large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
DR   GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0042255; P:ribosome assembly; IBA:GO_Central.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   CDD; cd00336; Ribosomal_L22; 1.
DR   Gene3D; 3.90.470.10; -; 1.
DR   InterPro; IPR001063; Ribosomal_L22.
DR   InterPro; IPR036394; Ribosomal_L22/L17_sf.
DR   InterPro; IPR005727; Ribosomal_L22_bac/chlpt-type.
DR   PANTHER; PTHR13501; PTHR13501; 1.
DR   Pfam; PF00237; Ribosomal_L22; 1.
DR   SUPFAM; SSF54843; SSF54843; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Mitochondrion; Reference proteome; Ribonucleoprotein;
KW   Ribosomal protein; Transit peptide.
FT   TRANSIT         1..38
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250"
FT   CHAIN           39..204
FT                   /note="39S ribosomal protein L22, mitochondrial"
FT                   /id="PRO_0000261643"
SQ   SEQUENCE   204 AA;  23552 MW;  00DE97CA41A86804 CRC64;
     MAAVILERLG ALWVQNLRGK LALGILPQSH IHTSASLEIS RKWEKKNKIV YPPQLPGEPR
     RPAEIYHCRR QIKYSKDKMW YLAKLIRGMS IDQALAQLEF SDKKGAQIIK EVLLEAQDMA
     VRDHNVEFRS NLYIAESTSG RGQYLKRIRY HGRGRFGIME KVFCHYFVKL VEGPPPPPEA
     PKTAVTHAKE YIQELRNRTI IHAL