RM19_MOUSE
ID RM19_MOUSE Reviewed; 292 AA.
AC Q9D338; Q543I0; Q8R1R0;
DT 26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=39S ribosomal protein L19, mitochondrial;
DE Short=L19mt;
DE Short=MRP-L19;
DE Flags: Precursor;
GN Name=Mrpl19;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Colon, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Retina;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC which comprises a 16S rRNA and about 50 distinct proteins.
CC {ECO:0000250|UniProtKB:P49406}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P49406}.
CC -!- SIMILARITY: Belongs to the bacterial ribosomal protein bL19 family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK018508; BAB31245.1; -; mRNA.
DR EMBL; AK050637; BAC34357.1; -; mRNA.
DR EMBL; BC020315; AAH20315.1; -; mRNA.
DR EMBL; BC043921; AAH43921.1; -; mRNA.
DR CCDS; CCDS39523.1; -.
DR RefSeq; NP_080766.1; NM_026490.2.
DR AlphaFoldDB; Q9D338; -.
DR SMR; Q9D338; -.
DR BioGRID; 207876; 33.
DR ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit.
DR STRING; 10090.ENSMUSP00000032124; -.
DR iPTMnet; Q9D338; -.
DR PhosphoSitePlus; Q9D338; -.
DR SwissPalm; Q9D338; -.
DR EPD; Q9D338; -.
DR jPOST; Q9D338; -.
DR MaxQB; Q9D338; -.
DR PaxDb; Q9D338; -.
DR PeptideAtlas; Q9D338; -.
DR PRIDE; Q9D338; -.
DR ProteomicsDB; 299858; -.
DR Antibodypedia; 31651; 184 antibodies from 23 providers.
DR DNASU; 56284; -.
DR Ensembl; ENSMUST00000032124; ENSMUSP00000032124; ENSMUSG00000030045.
DR GeneID; 56284; -.
DR KEGG; mmu:56284; -.
DR UCSC; uc009clf.2; mouse.
DR CTD; 9801; -.
DR MGI; MGI:1926274; Mrpl19.
DR VEuPathDB; HostDB:ENSMUSG00000030045; -.
DR eggNOG; KOG1698; Eukaryota.
DR GeneTree; ENSGT00390000009415; -.
DR HOGENOM; CLU_076988_1_0_1; -.
DR InParanoid; Q9D338; -.
DR OMA; IDHQGME; -.
DR OrthoDB; 1387536at2759; -.
DR PhylomeDB; Q9D338; -.
DR TreeFam; TF320270; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 56284; 19 hits in 108 CRISPR screens.
DR ChiTaRS; Mrpl19; mouse.
DR PRO; PR:Q9D338; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9D338; protein.
DR Bgee; ENSMUSG00000030045; Expressed in metanephric loop of Henle and 237 other tissues.
DR Genevisible; Q9D338; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005761; C:mitochondrial ribosome; ISS:MGI.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR Gene3D; 2.30.30.790; -; 1.
DR InterPro; IPR038657; L19_sf.
DR InterPro; IPR001857; Ribosomal_L19.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR15680; PTHR15680; 1.
DR Pfam; PF01245; Ribosomal_L19; 1.
DR PRINTS; PR00061; RIBOSOMALL19.
DR SUPFAM; SSF50104; SSF50104; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Phosphoprotein; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein; Transit peptide.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..292
FT /note="39S ribosomal protein L19, mitochondrial"
FT /id="PRO_0000030474"
FT REGION 41..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 77
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P49406"
SQ SEQUENCE 292 AA; 33578 MW; 2D85C99D97A59BF5 CRC64;
MAASMAESCR ASLYLARSVR MARPRLAAFA SDACRVCTGP SRFQSTGPSE PGGFKPPPKP
VIVDRRRVPE DERRFLSPEF IPPRGRTNPL KFKIERKDML DRRKVLPIPE FYVGSILRVT
TADPYASGKT SQFLGICIKR SGNGLGATFT LRNTIEGQGV EICFELYNPR IQEIQVVKLE
KRLDDNLLYL RDALPEYSTF DVNMKPVPQE ACQEVPVNKL KVKMKPKPWS KRWERPNFNI
KGIRFDLALT EEQMKEAQKW NKPWIEFDMM REYDTSKIEA ALWEEIEASK KS
