RM15_MOUSE
ID RM15_MOUSE Reviewed; 295 AA.
AC Q9CPR5; Q3UBN5; Q9CPP5; Q9CRH4;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=39S ribosomal protein L15, mitochondrial;
DE Short=L15mt;
DE Short=MRP-L15;
DE Flags: Precursor;
GN Name=Mrpl15;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, and Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, and Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC which comprises a 16S rRNA and about 50 distinct proteins.
CC {ECO:0000250|UniProtKB:Q9P015}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9P015}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9CPR5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9CPR5-2; Sequence=VSP_021370, VSP_021371;
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL15 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB27054.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK003367; BAB22741.1; -; mRNA.
DR EMBL; AK010474; BAB26967.1; -; mRNA.
DR EMBL; AK010604; BAB27054.1; ALT_INIT; mRNA.
DR EMBL; AK017804; BAB30943.1; -; mRNA.
DR EMBL; AK017824; BAB30958.1; -; mRNA.
DR EMBL; AK019175; BAB31589.1; -; mRNA.
DR EMBL; AK019249; BAB31626.1; -; mRNA.
DR EMBL; AK150880; BAE29929.1; -; mRNA.
DR EMBL; AK160660; BAE35948.1; -; mRNA.
DR EMBL; BC021304; AAH21304.1; -; mRNA.
DR EMBL; BC027233; AAH27233.1; -; mRNA.
DR CCDS; CCDS35504.1; -. [Q9CPR5-2]
DR CCDS; CCDS48211.1; -. [Q9CPR5-1]
DR RefSeq; NP_001171129.1; NM_001177658.1. [Q9CPR5-1]
DR RefSeq; NP_079576.1; NM_025300.4. [Q9CPR5-2]
DR AlphaFoldDB; Q9CPR5; -.
DR SMR; Q9CPR5; -.
DR BioGRID; 205202; 14.
DR ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit.
DR STRING; 10090.ENSMUSP00000115512; -.
DR iPTMnet; Q9CPR5; -.
DR PhosphoSitePlus; Q9CPR5; -.
DR EPD; Q9CPR5; -.
DR MaxQB; Q9CPR5; -.
DR PaxDb; Q9CPR5; -.
DR PeptideAtlas; Q9CPR5; -.
DR PRIDE; Q9CPR5; -.
DR ProteomicsDB; 260977; -. [Q9CPR5-1]
DR ProteomicsDB; 260978; -. [Q9CPR5-2]
DR Antibodypedia; 24498; 188 antibodies from 25 providers.
DR DNASU; 27395; -.
DR Ensembl; ENSMUST00000130201; ENSMUSP00000114649; ENSMUSG00000033845. [Q9CPR5-2]
DR Ensembl; ENSMUST00000156816; ENSMUSP00000115512; ENSMUSG00000033845. [Q9CPR5-1]
DR GeneID; 27395; -.
DR KEGG; mmu:27395; -.
DR UCSC; uc007afd.3; mouse. [Q9CPR5-2]
DR UCSC; uc007aff.3; mouse. [Q9CPR5-1]
DR CTD; 29088; -.
DR MGI; MGI:1351639; Mrpl15.
DR VEuPathDB; HostDB:ENSMUSG00000033845; -.
DR eggNOG; KOG0846; Eukaryota.
DR GeneTree; ENSGT00390000009040; -.
DR HOGENOM; CLU_055188_5_2_1; -.
DR InParanoid; Q9CPR5; -.
DR OMA; GHKREWQ; -.
DR OrthoDB; 930708at2759; -.
DR PhylomeDB; Q9CPR5; -.
DR TreeFam; TF105918; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 27395; 18 hits in 76 CRISPR screens.
DR ChiTaRS; Mrpl15; mouse.
DR PRO; PR:Q9CPR5; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9CPR5; protein.
DR Bgee; ENSMUSG00000033845; Expressed in morula and 249 other tissues.
DR ExpressionAtlas; Q9CPR5; baseline and differential.
DR Genevisible; Q9CPR5; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0003735; F:structural constituent of ribosome; ISA:MGI.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEP:MGI.
DR GO; GO:0000002; P:mitochondrial genome maintenance; TAS:MGI.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR GO; GO:0006412; P:translation; ISA:MGI.
DR HAMAP; MF_01341; Ribosomal_L15; 1.
DR InterPro; IPR036227; L18e/L15P_sf.
DR InterPro; IPR030878; Ribosomal_L15.
DR InterPro; IPR005749; Ribosomal_L15_bac-type.
DR InterPro; IPR021131; Ribosomal_L18e/L15P.
DR PANTHER; PTHR12934; PTHR12934; 1.
DR Pfam; PF00828; Ribosomal_L27A; 1.
DR SUPFAM; SSF52080; SSF52080; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Mitochondrion; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein; Transit peptide.
FT TRANSIT 1..20
FT /note="Mitochondrion"
FT /evidence="ECO:0000250|UniProtKB:Q0VC21"
FT CHAIN 21..295
FT /note="39S ribosomal protein L15, mitochondrial"
FT /id="PRO_0000257839"
FT REGION 21..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..57
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 184..204
FT /note="EILCKPIPFFLRGQPIPKRML -> GHLMHSSDFHGFSARYSIHIK (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_021370"
FT VAR_SEQ 205..295
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_021371"
FT CONFLICT 1
FT /note="M -> L (in Ref. 1; BAB27054)"
FT /evidence="ECO:0000305"
FT CONFLICT 13
FT /note="D -> G (in Ref. 1; BAB27054)"
FT /evidence="ECO:0000305"
FT CONFLICT 36
FT /note="E -> G (in Ref. 1; BAB27054)"
FT /evidence="ECO:0000305"
FT CONFLICT 119
FT /note="Q -> K (in Ref. 1; BAE29929)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 295 AA; 33542 MW; 2CAA781E82E4670C CRC64;
MAGTARGCGT SLDLLRSLPR VSLANLKPSP NSRKRERRPR DRRRGRKCGR GHKGERQRGT
RPRLGFEGGQ TPFYIRIPKY GFNEGHSFRH QYQPLSLRRL QYLIDLGRVD PTQPIDLTQL
VNGRGVTIQP LKRDYGVQLV EEGADTFQAK INIEVQLASE LAIAAIEKNG GVVTTAFYDP
RSLEILCKPI PFFLRGQPIP KRMLPPESLV PYYTDAKNRG YLADPAKFPE ARLELAMKFG
YVLPDITKDE LFRMLSARKD PRQIFFGLAP GWVVNMADKK ILKPTDENLL KYYSS
