RM03_MOUSE
ID RM03_MOUSE Reviewed; 348 AA.
AC Q99N95; Q3TF66; Q9CVE4;
DT 13-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=39S ribosomal protein L3, mitochondrial;
DE Short=L3mt;
DE Short=MRP-L3;
DE Flags: Precursor;
GN Name=Mrpl3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11279069; DOI=10.1074/jbc.m100432200;
RA Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A.,
RA Watanabe K.;
RT "Structural compensation for the deficit of rRNA with proteins in the
RT mammalian mitochondrial ribosome. Systematic analysis of protein components
RT of the large ribosomal subunit from mammalian mitochondria.";
RL J. Biol. Chem. 276:21724-21736(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Forelimb, and Liver;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart, Kidney, Liver, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC which comprises a 16S rRNA and about 50 distinct proteins.
CC {ECO:0000250|UniProtKB:P09001}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P09001}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL3 family.
CC {ECO:0000305}.
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DR EMBL; AB049633; BAB40838.1; -; mRNA.
DR EMBL; AK077857; BAC37036.1; -; mRNA.
DR EMBL; AK145687; BAE26589.1; -; mRNA.
DR EMBL; AK169272; BAE41032.1; -; mRNA.
DR EMBL; BC034877; AAH34877.1; -; mRNA.
DR CCDS; CCDS23462.1; -.
DR RefSeq; NP_444389.2; NM_053159.3.
DR AlphaFoldDB; Q99N95; -.
DR SMR; Q99N95; -.
DR BioGRID; 220434; 33.
DR ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit.
DR IntAct; Q99N95; 1.
DR STRING; 10090.ENSMUSP00000035177; -.
DR iPTMnet; Q99N95; -.
DR PhosphoSitePlus; Q99N95; -.
DR SwissPalm; Q99N95; -.
DR EPD; Q99N95; -.
DR MaxQB; Q99N95; -.
DR PaxDb; Q99N95; -.
DR PRIDE; Q99N95; -.
DR ProteomicsDB; 300517; -.
DR Antibodypedia; 33349; 200 antibodies from 33 providers.
DR DNASU; 94062; -.
DR Ensembl; ENSMUST00000035177; ENSMUSP00000035177; ENSMUSG00000032563.
DR GeneID; 94062; -.
DR KEGG; mmu:94062; -.
DR UCSC; uc009rht.1; mouse.
DR CTD; 11222; -.
DR MGI; MGI:2137204; Mrpl3.
DR VEuPathDB; HostDB:ENSMUSG00000032563; -.
DR eggNOG; KOG3141; Eukaryota.
DR GeneTree; ENSGT00390000011422; -.
DR InParanoid; Q99N95; -.
DR OMA; FRDSGVM; -.
DR OrthoDB; 1269775at2759; -.
DR PhylomeDB; Q99N95; -.
DR TreeFam; TF105634; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 94062; 20 hits in 74 CRISPR screens.
DR PRO; PR:Q99N95; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q99N95; protein.
DR Bgee; ENSMUSG00000032563; Expressed in endocardial cushion and 248 other tissues.
DR ExpressionAtlas; Q99N95; baseline and differential.
DR Genevisible; Q99N95; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:MGI.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR GO; GO:0006412; P:translation; ISO:MGI.
DR InterPro; IPR000597; Ribosomal_L3.
DR InterPro; IPR019927; Ribosomal_L3_bac/org-type.
DR InterPro; IPR019926; Ribosomal_L3_CS.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR PANTHER; PTHR11229; PTHR11229; 1.
DR Pfam; PF00297; Ribosomal_L3; 1.
DR SUPFAM; SSF50447; SSF50447; 1.
DR TIGRFAMs; TIGR03625; L3_bact; 1.
DR PROSITE; PS00474; RIBOSOMAL_L3; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW Transit peptide.
FT TRANSIT 1..40
FT /note="Mitochondrion"
FT /evidence="ECO:0000250|UniProtKB:Q3ZBX6"
FT CHAIN 41..348
FT /note="39S ribosomal protein L3, mitochondrial"
FT /id="PRO_0000077254"
SQ SEQUENCE 348 AA; 39110 MW; A4596B5BAC91EFF9 CRC64;
MPGWRLLAQA GARVLGCGAR GLGADPGLER RKNILFFVRN LHSKSSTWWD EHLSEENLSF
VKQLVSDENK TQLTSKLNPL KDEPWPLHPW EPGSFRVGLI ALKLGMMPLW TKDGQKHAVT
LLQVQDCHVL KYTPKEDHNG KIAALTVGGK TVSRFYKPDS RLEFYRDLGL PPKQIHKIFH
VTDNAVIKPG TPLYAAHFRP GQYVDVTAKT IGKGFQGVMK RWGFKGQPAS HGQTKTHRRP
GAISTGDIAR VWPGTKMPGR MGNQNRTVYG LKVWRVNTKH NIIYVNGSVP GHKNCLVKIK
DSTLPAYKDS CKNLPFPTYF PDGDEEELPE DLFDESVWQP SEPSITFA
