RL38_MOUSE
ID RL38_MOUSE Reviewed; 70 AA.
AC Q9JJI8;
DT 26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=60S ribosomal protein L38;
GN Name=Rpl38;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Shimizu K.;
RT "Positional cloning of tail-short gene.";
RL Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, Embryonic stem cell, and Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N-3; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Component of the large ribosomal subunit. The ribosome is a
CC large ribonucleoprotein complex responsible for the synthesis of
CC proteins in the cell. {ECO:0000250|UniProtKB:P63173}.
CC -!- SUBUNIT: Component of the large ribosomal subunit.
CC {ECO:0000250|UniProtKB:P63173}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P63173}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL38 family.
CC {ECO:0000305}.
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DR EMBL; AB037665; BAB03500.1; -; mRNA.
DR EMBL; AK002659; BAB22266.1; -; mRNA.
DR EMBL; AK010277; BAB26814.1; -; mRNA.
DR EMBL; AK010518; BAB27000.1; -; mRNA.
DR EMBL; AK012391; BAB28208.1; -; mRNA.
DR EMBL; BC055346; AAH55346.1; -; mRNA.
DR CCDS; CCDS36365.1; -.
DR RefSeq; NP_001041522.1; NM_001048057.1.
DR RefSeq; NP_001041523.1; NM_001048058.1.
DR RefSeq; NP_075861.1; NM_023372.2.
DR RefSeq; XP_006534072.1; XM_006534009.2.
DR RefSeq; XP_017170209.1; XM_017314720.1.
DR PDB; 6SWA; EM; 3.10 A; i=1-70.
DR PDB; 7CPU; EM; 2.82 A; Lk=1-70.
DR PDB; 7CPV; EM; 3.03 A; Lk=1-70.
DR PDB; 7LS1; EM; 3.30 A; e2=1-70.
DR PDB; 7LS2; EM; 3.10 A; e2=1-70.
DR PDBsum; 6SWA; -.
DR PDBsum; 7CPU; -.
DR PDBsum; 7CPV; -.
DR PDBsum; 7LS1; -.
DR PDBsum; 7LS2; -.
DR AlphaFoldDB; Q9JJI8; -.
DR SMR; Q9JJI8; -.
DR BioGRID; 212354; 74.
DR ComplexPortal; CPX-5262; 60S cytosolic large ribosomal subunit.
DR IntAct; Q9JJI8; 5.
DR MINT; Q9JJI8; -.
DR STRING; 10090.ENSMUSP00000102213; -.
DR iPTMnet; Q9JJI8; -.
DR PhosphoSitePlus; Q9JJI8; -.
DR SwissPalm; Q9JJI8; -.
DR EPD; Q9JJI8; -.
DR jPOST; Q9JJI8; -.
DR MaxQB; Q9JJI8; -.
DR PaxDb; Q9JJI8; -.
DR PRIDE; Q9JJI8; -.
DR ProteomicsDB; 253311; -.
DR TopDownProteomics; Q9JJI8; -.
DR Antibodypedia; 45939; 112 antibodies from 19 providers.
DR DNASU; 67671; -.
DR Ensembl; ENSMUST00000077915; ENSMUSP00000102211; ENSMUSG00000057322.
DR Ensembl; ENSMUST00000082092; ENSMUSP00000080741; ENSMUSG00000057322.
DR Ensembl; ENSMUST00000106599; ENSMUSP00000102209; ENSMUSG00000057322.
DR Ensembl; ENSMUST00000106602; ENSMUSP00000102213; ENSMUSG00000057322.
DR GeneID; 67671; -.
DR KEGG; mmu:67671; -.
DR UCSC; uc007mfk.1; mouse.
DR CTD; 6169; -.
DR MGI; MGI:1914921; Rpl38.
DR VEuPathDB; HostDB:ENSMUSG00000057322; -.
DR eggNOG; KOG3499; Eukaryota.
DR GeneTree; ENSGT00390000003718; -.
DR HOGENOM; CLU_152057_2_0_1; -.
DR InParanoid; Q9JJI8; -.
DR OMA; RCHRHLY; -.
DR OrthoDB; 1619070at2759; -.
DR PhylomeDB; Q9JJI8; -.
DR TreeFam; TF300215; -.
DR Reactome; R-MMU-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-MMU-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-MMU-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-MMU-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-MMU-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-MMU-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR BioGRID-ORCS; 67671; 29 hits in 67 CRISPR screens.
DR ChiTaRS; Rpl38; mouse.
DR PRO; PR:Q9JJI8; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9JJI8; protein.
DR Bgee; ENSMUSG00000057322; Expressed in yolk sac and 64 other tissues.
DR ExpressionAtlas; Q9JJI8; baseline and differential.
DR Genevisible; Q9JJI8; MM.
DR GO; GO:0005737; C:cytoplasm; IC:ComplexPortal.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IPI:ComplexPortal.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:MGI.
DR GO; GO:0033291; C:eukaryotic 80S initiation complex; IDA:MGI.
DR GO; GO:0042788; C:polysomal ribosome; ISO:MGI.
DR GO; GO:0014069; C:postsynaptic density; ISO:MGI.
DR GO; GO:0045202; C:synapse; IDA:SynGO.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:MGI.
DR GO; GO:0034463; P:90S preribosome assembly; IDA:MGI.
DR GO; GO:0048318; P:axial mesoderm development; IMP:MGI.
DR GO; GO:0002181; P:cytoplasmic translation; ISO:MGI.
DR GO; GO:0042474; P:middle ear morphogenesis; IMP:MGI.
DR GO; GO:0001503; P:ossification; IMP:MGI.
DR GO; GO:0006417; P:regulation of translation; IMP:MGI.
DR GO; GO:0022618; P:ribonucleoprotein complex assembly; IBA:GO_Central.
DR GO; GO:0007605; P:sensory perception of sound; IMP:MGI.
DR GO; GO:0001501; P:skeletal system development; IMP:MGI.
DR Gene3D; 3.30.720.90; -; 1.
DR InterPro; IPR002675; Ribosomal_L38e.
DR InterPro; IPR038464; Ribosomal_L38e_sf.
DR PANTHER; PTHR10965; PTHR10965; 1.
DR Pfam; PF01781; Ribosomal_L38e; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Cytoplasm; Isopeptide bond; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; Ubl conjugation.
FT CHAIN 1..70
FT /note="60S ribosomal protein L38"
FT /id="PRO_0000215436"
FT MOD_RES 9
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P63173"
FT MOD_RES 67
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P63173"
FT CROSSLNK 4
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P63173"
FT CROSSLNK 9
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2); alternate"
FT /evidence="ECO:0000250|UniProtKB:P63173"
SQ SEQUENCE 70 AA; 8204 MW; FDD9A0B7BC98DBBA CRC64;
MPRKIEEIKD FLLTARRKDA KSVKIKKNKD NVKFKVRCSR YLYTLVITDK EKAEKLKQSL
PPGLAVKDLK
