ID   RL1_MYCTU               Reviewed;         235 AA.
AC   P9WHC7; L0T625; P96932;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=50S ribosomal protein L1 {ECO:0000255|HAMAP-Rule:MF_01318};
GN   Name=rplA {ECO:0000255|HAMAP-Rule:MF_01318}; OrderedLocusNames=Rv0641;
GN   ORFNames=MTCY20H10.22;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Binds directly to 23S rRNA. The L1 stalk is quite mobile in
CC       the ribosome, and is involved in E site tRNA release.
CC       {ECO:0000255|HAMAP-Rule:MF_01318}.
CC   -!- FUNCTION: Protein L1 is also a translational repressor protein, it
CC       controls the translation of the L11 operon by binding to its mRNA.
CC       {ECO:0000255|HAMAP-Rule:MF_01318}.
CC   -!- SUBUNIT: Part of the 50S ribosomal subunit. {ECO:0000255|HAMAP-
CC       Rule:MF_01318}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_01318}.
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DR   EMBL; AL123456; CCP43384.1; -; Genomic_DNA.
DR   PIR; F70613; F70613.
DR   RefSeq; NP_215155.1; NC_000962.3.
DR   RefSeq; WP_003403292.1; NZ_NVQJ01000007.1.
DR   PDB; 7MSC; EM; 2.97 A; 8=1-235.
DR   PDB; 7MSH; EM; 3.23 A; 8=1-235.
DR   PDB; 7MSM; EM; 2.79 A; 8=1-235.
DR   PDB; 7MSZ; EM; 3.10 A; 8=1-235.
DR   PDB; 7MT2; EM; 2.76 A; 8=1-235.
DR   PDB; 7MT3; EM; 2.80 A; 8=1-235.
DR   PDB; 7MT7; EM; 2.71 A; 8=1-235.
DR   PDBsum; 7MSC; -.
DR   PDBsum; 7MSH; -.
DR   PDBsum; 7MSM; -.
DR   PDBsum; 7MSZ; -.
DR   PDBsum; 7MT2; -.
DR   PDBsum; 7MT3; -.
DR   PDBsum; 7MT7; -.
DR   AlphaFoldDB; P9WHC7; -.
DR   SMR; P9WHC7; -.
DR   STRING; 83332.Rv0641; -.
DR   PaxDb; P9WHC7; -.
DR   DNASU; 888043; -.
DR   GeneID; 45424601; -.
DR   GeneID; 888043; -.
DR   KEGG; mtu:Rv0641; -.
DR   TubercuList; Rv0641; -.
DR   eggNOG; COG0081; Bacteria.
DR   OMA; GWTDVDV; -.
DR   PhylomeDB; P9WHC7; -.
DR   PRO; PR:P9WHC7; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000470; P:maturation of LSU-rRNA; IBA:GO_Central.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR   CDD; cd00403; Ribosomal_L1; 1.
DR   Gene3D; 3.40.50.790; -; 1.
DR   HAMAP; MF_01318_B; Ribosomal_L1_B; 1.
DR   InterPro; IPR005878; Ribosom_L1_bac-type.
DR   InterPro; IPR002143; Ribosomal_L1.
DR   InterPro; IPR023674; Ribosomal_L1-like.
DR   InterPro; IPR028364; Ribosomal_L1/biogenesis.
DR   InterPro; IPR016095; Ribosomal_L1_3-a/b-sand.
DR   InterPro; IPR023673; Ribosomal_L1_CS.
DR   Pfam; PF00687; Ribosomal_L1; 1.
DR   PIRSF; PIRSF002155; Ribosomal_L1; 1.
DR   SUPFAM; SSF56808; SSF56808; 1.
DR   TIGRFAMs; TIGR01169; rplA_bact; 1.
DR   PROSITE; PS01199; RIBOSOMAL_L1; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome; Repressor; Ribonucleoprotein;
KW   Ribosomal protein; RNA-binding; rRNA-binding; Translation regulation;
KW   tRNA-binding.
FT   CHAIN           1..235
FT                   /note="50S ribosomal protein L1"
FT                   /id="PRO_0000125697"
SQ   SEQUENCE   235 AA;  24756 MW;  2ECD7F4DBD7763BF CRC64;
     MSKTSKAYRA AAAKVDRTNL YTPLQAAKLA KETSSTKQDA TVEVAIRLGV DPRKADQMVR
     GTVNLPHGTG KTARVAVFAV GEKADAAVAA GADVVGSDDL IERIQGGWLE FDAAIATPDQ
     MAKVGRIARV LGPRGLMPNP KTGTVTADVA KAVADIKGGK INFRVDKQAN LHFVIGKASF
     DEKLLAENYG AAIDEVLRLK PSSSKGRYLK KITVSTTTGP GIPVDPSITR NFAGE