ID   RIR1_HHV7J              Reviewed;         806 AA.
AC   P50641;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Ribonucleoside-diphosphate reductase large subunit-like protein {ECO:0000255|HAMAP-Rule:MF_04027};
GN   Name=RIR1 {ECO:0000255|HAMAP-Rule:MF_04027}; Synonyms=U28;
OS   Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=57278;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8709220; DOI=10.1128/jvi.70.9.5975-5989.1996;
RA   Nicholas J.;
RT   "Determination and analysis of the complete nucleotide sequence of human
RT   herpesvirus.";
RL   J. Virol. 70:5975-5989(1996).
RN   [2]
RP   LACK OF RIBONUCLEOTIDE REDUCTASE ACTIVITY.
RX   PubMed=10573165; DOI=10.1099/0022-1317-80-10-2713;
RA   Sun Y., Conner J.;
RT   "The U28 ORF of human herpesvirus-7 does not encode a functional
RT   ribonucleotide reductase R1 subunit.";
RL   J. Gen. Virol. 80:2713-2718(1999).
RN   [3]
RP   REVIEW.
RX   PubMed=18990579; DOI=10.1016/j.tibs.2008.09.008;
RA   Lembo D., Brune W.;
RT   "Tinkering with a viral ribonucleotide reductase.";
RL   Trends Biochem. Sci. 34:25-32(2009).
CC   -!- FUNCTION: Does not possess a ribonucleotide reductase activity.
CC       Betaherpesviruses probably use another strategy to expand the dNTP pool
CC       in a quiescent host cell. {ECO:0000255|HAMAP-Rule:MF_04027}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04027}. Host
CC       cytoplasm {ECO:0000255|HAMAP-Rule:MF_04027}.
CC   -!- SIMILARITY: Belongs to the ribonucleoside diphosphate reductase large
CC       chain family. {ECO:0000255|HAMAP-Rule:MF_04027}.
CC   -!- CAUTION: Lacks the conserved sequence Asn-x-Cys-x-Glu essential for
CC       ribonucleotide reductase activity. {ECO:0000255|HAMAP-Rule:MF_04027}.
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DR   EMBL; U43400; AAC54690.1; -; Genomic_DNA.
DR   PIR; T41930; T41930.
DR   RefSeq; YP_073768.1; NC_001716.2.
DR   SMR; P50641; -.
DR   PRIDE; P50641; -.
DR   DNASU; 3289486; -.
DR   GeneID; 3289486; -.
DR   KEGG; vg:3289486; -.
DR   Proteomes; UP000009246; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0044423; C:virion component; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   HAMAP; MF_04027; HSV_RIR1_betahv; 1.
DR   InterPro; IPR034716; HSV_RIR1_betahv.
DR   InterPro; IPR000788; RNR_lg_C.
DR   InterPro; IPR039718; Rrm1.
DR   PANTHER; PTHR11573; PTHR11573; 1.
DR   Pfam; PF02867; Ribonuc_red_lgC; 1.
DR   PRINTS; PR01183; RIBORDTASEM1.
DR   PROSITE; PS00089; RIBORED_LARGE; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Late protein; Reference proteome; Virion.
FT   CHAIN           1..806
FT                   /note="Ribonucleoside-diphosphate reductase large subunit-
FT                   like protein"
FT                   /id="PRO_0000187239"
SQ   SEQUENCE   806 AA;  93070 MW;  4BA516084FCCDCC0 CRC64;
     MDPNNKVSIN KNMGLLRKCL CHDEYNKKRF CYSRFHHKTL LYKQLYEISK ILRRLNSGLD
     MWCLRDAIIS ALGAMHDAPH VDRLLGQFYL KTNSASEFDS ISLILESENI LQKELIEFVR
     DSKVELEKIL QAAIHVWRAK FSPGVLAASR FLDEISNSFN GIEENIPTIF LRISVTLASQ
     IKKIEYLQKS FVSHKCPLVE EILILLYKRV CMLPFPCMSN LGLVSEKKSV FDTVFHNVSN
     FSLEDFLDIN SGFFLPAMLN GSYVSVNLTR YHYEAESLME LLLSQLQIVE KDTNKTTGLT
     IYLEIWHLSL LMWLDFCEIL PTTVQVKFCL ILPEIFMERL KTENSYWSVF HKALAINLGL
     YDESDFTSKY LECERTAEHA RIKTETLLDN ICRCLRRGQM GFIFRKNIHK YSMLPQIASY
     CLGNSMDVIP FEYGLNTAFR IALNLSYFVE NVSEEQKSHT NIDMFHYRDK IFNLKKMRKT
     VTELVLIGNA VIDYALENRD FLMDGIVNAR SLAICVTGLH SALMSMNLPF NSQLGCQLYR
     IVCENIYYSS VRTSMNCCKK GAEPCSFFQR SKYAQGILHC DLYDNVEYTL PNVLWTNLRS
     DIKKYGLRNL TFVSGSAMSK EFDLLNCSQS FCPIEGNKIL KRSSIKVLHP NPVFHSDLSV
     YSTELQTLYI PVYNGLFLNR FKNHLEYLSS VNYDVSKVNK NLFSEEEMQE MTIFLNAFDY
     SVNEMLNMYV GALPFTDHGQ ANVFFINKTE NMRDILVCLY QNGFKTGIYQ AVYKNQKCDG
     VNPSKKFDLL SGFSDGVVMS TMHVFQ