ID   RIPL1_DANRE             Reviewed;         406 AA.
AC   A0PJT0;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=RILP-like protein 1;
DE   AltName: Full=Rab-interacting lysosomal-like protein 1;
GN   Name=rilpl1; ORFNames=zgc:158490;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in the regulation of cell shape and polarity.
CC       Plays a role in cellular protein transport, including protein transport
CC       away from primary cilia. Neuroprotective protein (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.
CC       Cell projection, cilium {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RILPL family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI27601.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC127600; AAI27601.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001073132.2; NM_001079664.1.
DR   AlphaFoldDB; A0PJT0; -.
DR   SMR; A0PJT0; -.
DR   STRING; 7955.ENSDARP00000108755; -.
DR   PaxDb; A0PJT0; -.
DR   GeneID; 780843; -.
DR   KEGG; dre:780843; -.
DR   CTD; 353116; -.
DR   ZFIN; ZDB-GENE-061201-51; rilpl1.
DR   eggNOG; ENOG502QR9G; Eukaryota.
DR   InParanoid; A0PJT0; -.
DR   OrthoDB; 890179at2759; -.
DR   PhylomeDB; A0PJT0; -.
DR   PRO; PR:A0PJT0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0016020; C:membrane; IEA:GOC.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR   GO; GO:0003382; P:epithelial cell morphogenesis; ISS:UniProtKB.
DR   GO; GO:1903445; P:protein transport from ciliary membrane to plasma membrane; ISS:UniProtKB.
DR   GO; GO:1901214; P:regulation of neuron death; ISS:UniProtKB.
DR   InterPro; IPR019143; JNK/Rab-associated_protein-1_N.
DR   InterPro; IPR034743; RH1.
DR   InterPro; IPR034744; RH2.
DR   InterPro; IPR021563; RILP_dimer.
DR   Pfam; PF09744; Jnk-SapK_ap_N; 1.
DR   Pfam; PF11461; RILP; 1.
DR   PROSITE; PS51776; RH1; 1.
DR   PROSITE; PS51777; RH2; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..406
FT                   /note="RILP-like protein 1"
FT                   /id="PRO_0000299312"
FT   DOMAIN          5..99
FT                   /note="RH1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01112"
FT   DOMAIN          289..358
FT                   /note="RH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01113"
FT   REGION          234..272
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          323..351
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          105..319
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        240..258
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   406 AA;  46917 MW;  A35711803C61ED4C CRC64;
     MEEQQLGAAL DKSAAELSVM DVYDIAAALG LELERVIERT GAELLSRLVP RVVRVLELLE
     VLVSRSSSSP DTDELRLELD RLRLERLERL EKEKKHKKEL ELVEDVWRGE AQDLLCQISQ
     LQEENKTLLN NLSIRESPLT EEDIQKQEGM TERERQVMKK LKEVVDKQRD EIRAKDRELT
     LKNDDVEALQ QQMSRLMKIN QDVRHRVSVV EAQGKSLIQQ KVELEAAAQT QQQEVSSLRQ
     EVSRLKEKLK EQSRSNEEEA QEPVGPPSPA QEALCDEDLS TVDLKDPNRP RFTLQELRDV
     LHERNELKAK VFMLQEEIAY YRSEEQEEEN GPPLPDPSET LRTNPRSNFQ PESGIKRLFS
     FFSRDRSVSQ RRMMLNVEPV GDAVGSWTGK QEDVYTETAQ EALQHM