ID   RIPB_XENLA              Reviewed;         220 AA.
AC   Q5M782;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 2.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=RPA-interacting protein B;
GN   Name=rpain-b; Synonyms=rip-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the import of RPA complex into the nucleus, via its
CC       interaction with importin beta. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts directly with the RPA1 subunit of RPA complex.
CC       Interacts with importin beta, but not with importin alpha. Forms a
CC       complex with the RPA complex and importin beta, which is dissociated by
CC       Ran-GTP (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH88792.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC088792; AAH88792.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001088906.2; NM_001095437.2.
DR   AlphaFoldDB; Q5M782; -.
DR   GeneID; 496256; -.
DR   KEGG; xla:496256; -.
DR   CTD; 496256; -.
DR   Xenbase; XB-GENE-6252220; rpain.L.
DR   OMA; WCPICKK; -.
DR   OrthoDB; 1518754at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 496256; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR028156; RIP.
DR   InterPro; IPR028159; RPA_interact_C_dom.
DR   InterPro; IPR028155; RPA_interact_central.
DR   InterPro; IPR028158; RPA_interact_N_dom.
DR   PANTHER; PTHR31742; PTHR31742; 1.
DR   Pfam; PF14768; RPA_interact_C; 1.
DR   Pfam; PF14767; RPA_interact_M; 1.
DR   Pfam; PF14766; RPA_interact_N; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..220
FT                   /note="RPA-interacting protein B"
FT                   /id="PRO_0000076303"
FT   ZN_FING         138..213
FT                   /note="RIP-type"
FT   REGION          1..45
FT                   /note="Interaction with importin beta"
FT                   /evidence="ECO:0000250"
FT   REGION          49..165
FT                   /note="Interaction with RPA1"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   220 AA;  25109 MW;  B46961D3980834C4 CRC64;
     MEAERRHRAL YKGTTPPWKE TYRKRCVERL KSNRSKLLDK FRQVGERIHG GVGGSFLVQE
     VMEEEWKVMQ FENGGFPSMW KKDAFSQDPD ELATLEEIKQ ELLLEEKAMV EEFENILQFE
     EQCFDSVVEL STGDQIVCPV CNRNYLTVTS CFIVCQCGVY INTQSQGMSI EKLHSLLESN
     LTAHAYHCNK LPVFSVATEL GGAASLFMSC QECDAMVVIL