ID   RIPA_XENLA              Reviewed;         226 AA.
AC   Q9W704; Q6GMZ2;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=RPA-interacting protein A;
DE   AltName: Full=RPA-interacting protein alpha;
DE   AltName: Full=XRIPalpha;
GN   Name=rpain-a; Synonyms=rip-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION
RP   WITH IMPORTIN BETA AND RPA1.
RX   PubMed=10428972; DOI=10.1093/emboj/18.15.4348;
RA   Jullien D., Goerlich D., Laemmli U.K., Adachi Y.;
RT   "Nuclear import of RPA in Xenopus egg extracts requires a novel protein
RT   XRIPalpha but not importin alpha.";
RL   EMBO J. 18:4348-4358(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the import of RPA complex into the nucleus, via its
CC       interaction with importin beta. {ECO:0000269|PubMed:10428972}.
CC   -!- SUBUNIT: Interacts directly with the rpa1 subunit of RPA complex.
CC       Interacts with importin beta, but not with importin alpha. Forms a
CC       complex with the RPA complex and importin beta, which is dissociated by
CC       Ran-GTP. {ECO:0000269|PubMed:10428972}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10428972}.
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DR   EMBL; AJ243177; CAB45690.1; -; mRNA.
DR   EMBL; BC073732; AAH73732.1; -; mRNA.
DR   RefSeq; NP_001081708.1; NM_001088239.1.
DR   AlphaFoldDB; Q9W704; -.
DR   DNASU; 398009; -.
DR   GeneID; 398009; -.
DR   KEGG; xla:398009; -.
DR   CTD; 398009; -.
DR   Xenbase; XB-GENE-5817283; rpain.S.
DR   OMA; EHSTHCP; -.
DR   OrthoDB; 1518754at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 398009; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR028156; RIP.
DR   InterPro; IPR028159; RPA_interact_C_dom.
DR   InterPro; IPR028155; RPA_interact_central.
DR   InterPro; IPR028158; RPA_interact_N_dom.
DR   PANTHER; PTHR31742; PTHR31742; 1.
DR   Pfam; PF14768; RPA_interact_C; 1.
DR   Pfam; PF14767; RPA_interact_M; 1.
DR   Pfam; PF14766; RPA_interact_N; 1.
PE   1: Evidence at protein level;
KW   Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..226
FT                   /note="RPA-interacting protein A"
FT                   /id="PRO_0000076302"
FT   ZN_FING         144..219
FT                   /note="RIP-type"
FT   REGION          1..45
FT                   /note="Interaction with importin beta"
FT   REGION          49..171
FT                   /note="Interaction with RPA1"
FT                   /evidence="ECO:0000269|PubMed:10428972"
FT   CONFLICT        172
FT                   /note="Q -> R (in Ref. 2; AAH73732)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   226 AA;  25775 MW;  FB98A97044EFE084 CRC64;
     MEAERRHRAL YKGTTPPWKE TYRKRCVERL KRNRSKLLDK FRQVGERIHG GVGGSFLVQE
     VMEEEWKAMQ SENGSFPSMW KKEAFSQALN IMRDPDELAT LEEIKQELLL EEKAMIEEFE
     NILQFEEQCL DSVVELSTGD QIVCPVCNRN YLTVTSCFIV CQCGVYINTQ SQGMSIEKLH
     SLLESSLTSH GYHCTKLPVF SVATELGGAA SLFMSCQECD AMVVIL