RIPA_COREF
ID RIPA_COREF Reviewed; 332 AA.
AC Q8FQS2;
DT 07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-FEB-2006, sequence version 2.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=HTH-type transcriptional regulator RipA {ECO:0000250|UniProtKB:Q8NRR3};
DE AltName: Full=Repressor of iron proteins A {ECO:0000250|UniProtKB:Q8NRR3};
DE Short=RIPA {ECO:0000250|UniProtKB:Q8NRR3};
GN Name=ripA {ECO:0000250|UniProtKB:Q8NRR3}; OrderedLocusNames=CE1047;
OS Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189
OS / NBRC 100395).
OC Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC Corynebacterium.
OX NCBI_TaxID=196164;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395;
RX PubMed=12840036; DOI=10.1101/gr.1285603;
RA Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S.,
RA Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.;
RT "Comparative complete genome sequence analysis of the amino acid
RT replacements responsible for the thermostability of Corynebacterium
RT efficiens.";
RL Genome Res. 13:1572-1579(2003).
CC -!- FUNCTION: Under iron limitation, represses the acn (aconitase), catA
CC (catechol 1,2 dioxygenase), leuCD (isopropylmalate dehydratase),
CC narKGHJI (nitrite/nitrate transporter and nitrate reductase), sdhCAB
CC (succinate dehydrogenase), pta (phosphotransacetylase) and katA
CC (catalase) genes. {ECO:0000250|UniProtKB:Q8NRR3}.
CC -!- INDUCTION: Repressed by DtxR under iron excess.
CC {ECO:0000250|UniProtKB:Q8NRR3}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC17857.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; BA000035; BAC17857.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_006769994.1; NZ_GG700688.1.
DR AlphaFoldDB; Q8FQS2; -.
DR SMR; Q8FQS2; -.
DR STRING; 196164.23492885; -.
DR EnsemblBacteria; BAC17857; BAC17857; BAC17857.
DR KEGG; cef:CE1047; -.
DR eggNOG; COG2207; Bacteria.
DR HOGENOM; CLU_810658_0_0_11; -.
DR OrthoDB; 1757088at2; -.
DR Proteomes; UP000001409; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR018060; HTH_AraC.
DR InterPro; IPR018062; HTH_AraC-typ_CS.
DR Pfam; PF12833; HTH_18; 1.
DR SMART; SM00342; HTH_ARAC; 1.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..332
FT /note="HTH-type transcriptional regulator RipA"
FT /id="PRO_0000223238"
FT DOMAIN 112..209
FT /note="HTH araC/xylS-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 129..150
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 176..199
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ SEQUENCE 332 AA; 35447 MW; 2A52BC6B7EB12743 CRC64;
MNNARLLWCH SGVVNVCLGE QTFTLVAGDL LYAPEGAFWS DTGSGLILEL RFRILGIDGP
ARRIHLGRAW AERMVHEYSR SLFGEDAVSG DVAKLFADRV PTPPLPAPRH ARAVAQTLAA
NPADQTSLEE FAAQRGVSAR TLQRQFLSST GYSFSEWRAA QRVCVATSLL AHDFSIAVVA
NLVGFSATSS LTRAFRRHIG TTPSAFTTGG IGMGVAGTPA AIPSRTTFAA ATRDQQLWIY
TGTATVTTPG YCRFLTQGDM ATIPAGTHTR IDVAAGSIAI PVPIGVGEQG MSLQEVATLR
DQEPSTGLML VEESRWVHLG RELLPATAPV SL
