RIPA_CORDI
ID RIPA_CORDI Reviewed; 335 AA.
AC Q6NI56;
DT 07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=HTH-type transcriptional regulator RipA {ECO:0000250|UniProtKB:Q8NRR3};
DE AltName: Full=Repressor of iron proteins A {ECO:0000250|UniProtKB:Q8NRR3};
DE Short=RIPA {ECO:0000250|UniProtKB:Q8NRR3};
GN Name=ripA {ECO:0000250|UniProtKB:Q8NRR3}; OrderedLocusNames=DIP0922;
OS Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype
OS gravis).
OC Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC Corynebacterium.
OX NCBI_TaxID=257309;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700971 / NCTC 13129 / Biotype gravis;
RX PubMed=14602910; DOI=10.1093/nar/gkg874;
RA Cerdeno-Tarraga A.-M., Efstratiou A., Dover L.G., Holden M.T.G.,
RA Pallen M.J., Bentley S.D., Besra G.S., Churcher C.M., James K.D.,
RA De Zoysa A., Chillingworth T., Cronin A., Dowd L., Feltwell T., Hamlin N.,
RA Holroyd S., Jagels K., Moule S., Quail M.A., Rabbinowitsch E.,
RA Rutherford K.M., Thomson N.R., Unwin L., Whitehead S., Barrell B.G.,
RA Parkhill J.;
RT "The complete genome sequence and analysis of Corynebacterium diphtheriae
RT NCTC13129.";
RL Nucleic Acids Res. 31:6516-6523(2003).
CC -!- FUNCTION: Under iron limitation, represses the acn (aconitase), catA
CC (catechol 1,2 dioxygenase), leuCD (isopropylmalate dehydratase),
CC narKGHJI (nitrite/nitrate transporter and nitrate reductase), sdhCAB
CC (succinate dehydrogenase), pta (phosphotransacetylase) and katA
CC (catalase) genes. {ECO:0000250|UniProtKB:Q8NRR3}.
CC -!- INDUCTION: Repressed by DtxR under iron excess.
CC {ECO:0000250|UniProtKB:Q8NRR3}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX248356; CAE49439.1; -; Genomic_DNA.
DR RefSeq; WP_010934672.1; NC_002935.2.
DR AlphaFoldDB; Q6NI56; -.
DR SMR; Q6NI56; -.
DR STRING; 257309.DIP0922; -.
DR DNASU; 2649962; -.
DR EnsemblBacteria; CAE49439; CAE49439; DIP0922.
DR KEGG; cdi:DIP0922; -.
DR HOGENOM; CLU_810658_0_0_11; -.
DR OMA; HPSECIA; -.
DR OrthoDB; 1757088at2; -.
DR Proteomes; UP000002198; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR018060; HTH_AraC.
DR InterPro; IPR018062; HTH_AraC-typ_CS.
DR Pfam; PF12833; HTH_18; 1.
DR SMART; SM00342; HTH_ARAC; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..335
FT /note="HTH-type transcriptional regulator RipA"
FT /id="PRO_0000223237"
FT DOMAIN 119..216
FT /note="HTH araC/xylS-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 136..157
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 183..206
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ SEQUENCE 335 AA; 36067 MW; 303003C3FF02B969 CRC64;
MSLPSIKTTN SYCVVLWCDQ GSATINAPDR VVQVMAGDVV LAPHGAFVTG HGVVLPMAFP
DFDGGEHTRR LHMGTAWSKR MIFEFSRSLL GETRPSECIA ALFDDRARPP RVPEPQAARK
VAQKLIAYPA DQTPLLEFAQ LHNISSRTLQ RQFVASTGFT FSEWRAALRV SVAADLLAHD
FRIGQVSQMV GFSATSSLTR AFKRHTGDTP SSFTSPRMHA VCEQQPPMIP ATTTFARASD
DIALWIYSGT ATVTTPGYCR FMGAGETVTI PSGTSTRLDV SAGSVALPVP LAAAHDDLTL
SDVLAASVNP LAAVELQRLS AQERADVEQV LVPSV
