RINT1_DROME
ID RINT1_DROME Reviewed; 724 AA.
AC Q9VS46; Q961W7;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=RINT1-like protein;
DE Short=DmRINT-1;
GN Name=Rint1 {ECO:0000312|FlyBase:FBgn0035762};
GN ORFNames=CG8605 {ECO:0000312|FlyBase:FBgn0035762};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP FUNCTION.
RX PubMed=22685323; DOI=10.1242/jcs.099820;
RA Wainman A., Giansanti M.G., Goldberg M.L., Gatti M.;
RT "The Drosophila RZZ complex - roles in membrane trafficking and
RT cytokinesis.";
RL J. Cell Sci. 125:4014-4025(2012).
CC -!- FUNCTION: During cytokinesis in male meiotic cells, required for
CC completion of cleavage furrow ingression possibly in conjunction with
CC Zw10. Required for maintenance of Golgi stack number and morphology.
CC Essential for acroblast assembly. {ECO:0000269|PubMed:22685323}.
CC -!- SIMILARITY: Belongs to the RINT1 family. {ECO:0000305}.
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DR EMBL; AE014296; AAF50583.2; -; Genomic_DNA.
DR EMBL; AY047513; AAK77245.1; -; mRNA.
DR RefSeq; NP_648102.2; NM_139845.3.
DR AlphaFoldDB; Q9VS46; -.
DR SMR; Q9VS46; -.
DR BioGRID; 64247; 4.
DR IntAct; Q9VS46; 3.
DR STRING; 7227.FBpp0076549; -.
DR PaxDb; Q9VS46; -.
DR PRIDE; Q9VS46; -.
DR DNASU; 38807; -.
DR EnsemblMetazoa; FBtr0076838; FBpp0076549; FBgn0035762.
DR GeneID; 38807; -.
DR KEGG; dme:Dmel_CG8605; -.
DR UCSC; CG8605-RA; d. melanogaster.
DR CTD; 60561; -.
DR FlyBase; FBgn0035762; Rint1.
DR VEuPathDB; VectorBase:FBgn0035762; -.
DR eggNOG; KOG2218; Eukaryota.
DR GeneTree; ENSGT00390000017006; -.
DR HOGENOM; CLU_020201_0_0_1; -.
DR InParanoid; Q9VS46; -.
DR OMA; WPFVGPP; -.
DR OrthoDB; 1393136at2759; -.
DR PhylomeDB; Q9VS46; -.
DR Reactome; R-DME-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR BioGRID-ORCS; 38807; 1 hit in 1 CRISPR screen.
DR ChiTaRS; Rint1; fly.
DR GenomeRNAi; 38807; -.
DR PRO; PR:Q9VS46; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0035762; Expressed in oviduct (Drosophila) and 33 other tissues.
DR ExpressionAtlas; Q9VS46; baseline and differential.
DR Genevisible; Q9VS46; DM.
DR GO; GO:0070939; C:Dsl1/NZR complex; ISS:FlyBase.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:FlyBase.
DR GO; GO:0036090; P:cleavage furrow ingression; IMP:FlyBase.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0007030; P:Golgi organization; IMP:FlyBase.
DR GO; GO:0048193; P:Golgi vesicle transport; ISS:FlyBase.
DR GO; GO:0007112; P:male meiosis cytokinesis; IMP:FlyBase.
DR GO; GO:0060628; P:regulation of ER to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IBA:GO_Central.
DR Gene3D; 1.20.58.670; -; 1.
DR InterPro; IPR042044; EXOC6PINT-1/Sec15/Tip20_C_dom2.
DR InterPro; IPR007528; RINT1_Tip20.
DR PANTHER; PTHR13520; PTHR13520; 1.
DR Pfam; PF04437; RINT1_TIP1; 1.
DR PROSITE; PS51386; RINT1_TIP20; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..724
FT /note="RINT1-like protein"
FT /id="PRO_0000097348"
FT DOMAIN 163..724
FT /note="RINT1/TIP20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00717"
FT CONFLICT 285
FT /note="K -> N (in Ref. 3; AAK77245)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 724 AA; 83535 MW; 7788CD208A44A5BD CRC64;
MHAELSEMEL RIVARLNEEI GKDASQLHRA SHLVSHYKKH LQVLSQTLDY EDPQNVSCYK
TAFQCQQQVC ESIDFELEKL AHFEDKLKRK LKECQPVLEG VAEDLDKVRQ LQRLQQYLLL
VQDIQEISAA LGNAINGKDE DKLVNIYLTL YEGNDCEHSV VGRLHAVQAQ SLKSFAERTA
IYWHKLLLKR LSSAFEAVLK SMRWAHLEQQ ALNYSSARDT AKAQLLAEYM FLIKSPAEER
APLQSITPSI VCQPINRVVQ LLLAPYRQRF QFHFTGTRQT NRLDKPEWFY TQILNWGKET
HFFVGKTFQP AAIKAGKLDY NLRLEFIRGL VQLAIEKLAV DIEQIAQDQI LFAHLLDETL
AFESELRETF GYPASFPSAI SVITQPMYLL RWISLEERFC AEKMDDILQA ETPFQLIDPN
SFENDLKIPK CADQFMRLLD AIKDRYYGLI QPGHQLQFLH LQLELIDSFR QRLVQLHSSG
AVPSIPILNA INYLVMVLRE WGENVHYLHL HAALAGPNAT EINSVFEHAV AELEHWARQL
MRNLATKATN EMKAKSMSYR RDAWPTMPEQ NSREPFILSP SGGEMFQVLV TLLHNLEREL
SANLFTQTLR LIAHQIDDFM LESMVMNTKF SAAGAAQFNY DMTRNLFALF GQYTRRPELL
FKRTHDACKL LAAARGTALL LLETLRGNQS VEEKTKPLRE LHVLSMDSKQ CIEVLERRMD
IKMF
