RIMS4_HUMAN
ID RIMS4_HUMAN Reviewed; 269 AA.
AC Q9H426; A4FU94; E1P613; Q3MI44; Q5JWT7;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-JAN-2004, sequence version 3.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Regulating synaptic membrane exocytosis protein 4;
DE AltName: Full=RIM4 gamma;
DE AltName: Full=Rab3-interacting molecule 4;
DE Short=RIM 4;
GN Name=RIMS4; Synonyms=C20orf190;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=12620390; DOI=10.1016/s0888-7543(02)00024-1;
RA Wang Y., Suedhof T.C.;
RT "Genomic definition of RIM proteins: evolutionary amplification of a family
RT of synaptic regulatory proteins.";
RL Genomics 81:126-137(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-269 (ISOFORM 1), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 2-269 (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-254 AND SER-257, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic kidney;
RX PubMed=17525332; DOI=10.1126/science.1140321;
RA Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E.,
RA Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y.,
RA Gygi S.P., Elledge S.J.;
RT "ATM and ATR substrate analysis reveals extensive protein networks
RT responsive to DNA damage.";
RL Science 316:1160-1166(2007).
CC -!- FUNCTION: Regulates synaptic membrane exocytosis. {ECO:0000250}.
CC -!- SUBUNIT: Binds PPFIA3 (By similarity). Does not bind RAB3.
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q9H426; Q96FA3: PELI1; NbExp=3; IntAct=EBI-6660974, EBI-448369;
CC -!- SUBCELLULAR LOCATION: Synapse {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9H426-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H426-2; Sequence=VSP_044881;
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DR EMBL; AY326954; AAQ01681.1; -; mRNA.
DR EMBL; AL118522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471077; EAW75897.1; -; Genomic_DNA.
DR EMBL; CH471077; EAW75898.1; -; Genomic_DNA.
DR EMBL; BC104190; AAI04191.1; -; mRNA.
DR EMBL; BC112985; AAI12986.1; -; mRNA.
DR CCDS; CCDS13338.1; -. [Q9H426-1]
DR CCDS; CCDS56191.1; -. [Q9H426-2]
DR RefSeq; NP_001192246.1; NM_001205317.1. [Q9H426-2]
DR RefSeq; NP_892015.1; NM_182970.3. [Q9H426-1]
DR AlphaFoldDB; Q9H426; -.
DR SMR; Q9H426; -.
DR BioGRID; 126676; 7.
DR IntAct; Q9H426; 3.
DR STRING; 9606.ENSP00000439287; -.
DR iPTMnet; Q9H426; -.
DR PhosphoSitePlus; Q9H426; -.
DR BioMuta; RIMS4; -.
DR DMDM; 41017798; -.
DR EPD; Q9H426; -.
DR jPOST; Q9H426; -.
DR MassIVE; Q9H426; -.
DR PaxDb; Q9H426; -.
DR PeptideAtlas; Q9H426; -.
DR PRIDE; Q9H426; -.
DR ProteomicsDB; 15214; -.
DR ProteomicsDB; 80783; -. [Q9H426-1]
DR Antibodypedia; 43706; 118 antibodies from 25 providers.
DR DNASU; 140730; -.
DR Ensembl; ENST00000372851.8; ENSP00000361942.4; ENSG00000101098.13. [Q9H426-1]
DR Ensembl; ENST00000541604.2; ENSP00000439287.1; ENSG00000101098.13. [Q9H426-2]
DR GeneID; 140730; -.
DR KEGG; hsa:140730; -.
DR MANE-Select; ENST00000372851.8; ENSP00000361942.4; NM_182970.4; NP_892015.1.
DR UCSC; uc002xms.4; human. [Q9H426-1]
DR CTD; 140730; -.
DR DisGeNET; 140730; -.
DR GeneCards; RIMS4; -.
DR HGNC; HGNC:16183; RIMS4.
DR HPA; ENSG00000101098; Tissue enhanced (brain).
DR MIM; 611601; gene.
DR neXtProt; NX_Q9H426; -.
DR OpenTargets; ENSG00000101098; -.
DR PharmGKB; PA25733; -.
DR VEuPathDB; HostDB:ENSG00000101098; -.
DR eggNOG; KOG2060; Eukaryota.
DR GeneTree; ENSGT00940000158934; -.
DR HOGENOM; CLU_071205_0_0_1; -.
DR InParanoid; Q9H426; -.
DR OMA; GLYMERS; -.
DR OrthoDB; 109268at2759; -.
DR PhylomeDB; Q9H426; -.
DR PathwayCommons; Q9H426; -.
DR SignaLink; Q9H426; -.
DR BioGRID-ORCS; 140730; 13 hits in 1067 CRISPR screens.
DR ChiTaRS; RIMS4; human.
DR GenomeRNAi; 140730; -.
DR Pharos; Q9H426; Tbio.
DR PRO; PR:Q9H426; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9H426; protein.
DR Bgee; ENSG00000101098; Expressed in sural nerve and 140 other tissues.
DR Genevisible; Q9H426; HS.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0048786; C:presynaptic active zone; TAS:ParkinsonsUK-UCL.
DR GO; GO:0097060; C:synaptic membrane; ISS:ParkinsonsUK-UCL.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0044325; F:transmembrane transporter binding; ISS:ParkinsonsUK-UCL.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR GO; GO:0006836; P:neurotransmitter transport; IEA:UniProtKB-KW.
DR GO; GO:0042391; P:regulation of membrane potential; ISS:ParkinsonsUK-UCL.
DR GO; GO:2000300; P:regulation of synaptic vesicle exocytosis; ISS:ParkinsonsUK-UCL.
DR Gene3D; 2.60.40.150; -; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR039032; Rim-like.
DR PANTHER; PTHR12157; PTHR12157; 1.
DR Pfam; PF00168; C2; 1.
DR SMART; SM00239; C2; 1.
DR SUPFAM; SSF49562; SSF49562; 1.
DR PROSITE; PS50004; C2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Exocytosis; Neurotransmitter transport;
KW Phosphoprotein; Reference proteome; Synapse; Transport.
FT CHAIN 1..269
FT /note="Regulating synaptic membrane exocytosis protein 4"
FT /id="PRO_0000190207"
FT DOMAIN 115..233
FT /note="C2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT MOD_RES 254
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17525332"
FT MOD_RES 257
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17525332"
FT VAR_SEQ 32
FT /note="A -> AE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_044881"
SQ SEQUENCE 269 AA; 29329 MW; A0199FD06A3986FA CRC64;
MERSQSRLSL SASFEALAIY FPCMNSFDDE DAGDSRRLKG AIQRSTETGL AVEMPSRTLR
QASHESIEDS MNSYGSEGNL NYGGVCLASD AQFSDFLGSM GPAQFVGRQT LATTPMGDVE
IGLQERNGQL EVDIIQARGL TAKPGSKTLP AAYIKAYLLE NGICIAKKKT KVARKSLDPL
YNQVLLFPES PQGKVLQVIV WGNYGRMERK QFMGVARVLL EELDLTTLAV GWYKLFPTSS
MVDPATGPLL RQASQLSLES TVGPCGERS
