RHG20_HUMAN
ID RHG20_HUMAN Reviewed; 1191 AA.
AC Q9P2F6; A8K8C5; B0YIW7; B0YIW8; Q6RJU1; Q6RJU2; Q6RJU3; Q6RJU5; Q8IXS1;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Rho GTPase-activating protein 20;
DE AltName: Full=Rho-type GTPase-activating protein 20;
GN Name=ARHGAP20; Synonyms=KIAA1391;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), TISSUE SPECIFICITY,
RP DEVELOPMENTAL STAGE, AND CHROMOSOMAL TRANSLOCATION WITH BRWD3.
RX PubMed=15543602; DOI=10.1002/gcc.20131;
RA Kalla C., Nentwich H., Schlotter M., Mertens D., Wildenberger K.,
RA Doehner H., Stilgenbauer S., Lichter P.;
RT "Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic leukemia
RT disrupts two novel genes.";
RL Genes Chromosomes Cancer 42:128-143(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=10718198; DOI=10.1093/dnares/7.1.65;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVI. The
RT complete sequences of 150 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:65-73(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG NHLBI resequencing and genotyping service (RS&G);
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 436-1185 (ISOFORMS 1/2/3/4).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 436-1185 (ISOFORMS 1/2/3/4), AND
RP VARIANT ASP-632.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP IDENTIFICATION.
RX PubMed=14532992;
RA Katoh M., Katoh M.;
RT "Identification and characterization of human KIAA1391 and mouse Kiaa1391
RT genes encoding novel RhoGAP family proteins with RA domain and ANXL
RT repeats.";
RL Int. J. Oncol. 23:1471-1476(2003).
CC -!- FUNCTION: GTPase activator for the Rho-type GTPases by converting them
CC to an inactive GDP-bound state. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1; Synonyms=1ad;
CC IsoId=Q9P2F6-1; Sequence=Displayed;
CC Name=2; Synonyms=1be;
CC IsoId=Q9P2F6-2; Sequence=VSP_024294;
CC Name=3; Synonyms=1c;
CC IsoId=Q9P2F6-3; Sequence=VSP_024295;
CC Name=4; Synonyms=1e, 1d;
CC IsoId=Q9P2F6-4; Sequence=VSP_024296;
CC -!- TISSUE SPECIFICITY: Expressed predominantly in the brain. Lower
CC expression is found in lymph nodes. {ECO:0000269|PubMed:15543602}.
CC -!- DEVELOPMENTAL STAGE: Low expression is found in fetal liver.
CC {ECO:0000269|PubMed:15543602}.
CC -!- DISEASE: Note=A chromosomal aberration involving ARHGAP20 may be a
CC cause of B-cell chronic lymphocytic leukemia (B-CLL) (PubMed:15543602).
CC Translocation t(X;11)(q21;q23) with BRWD3 does not result in fusion
CC transcripts but disrupts both genes (PubMed:15543602).
CC {ECO:0000269|PubMed:15543602}.
CC -!- CAUTION: The translocation involving this gene was originally published
CC as t(X;11)(q13;23), but BRWD3 is localized to Xq21 and not to Xq13.
CC {ECO:0000305|PubMed:15543602}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH39340.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH39340.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
CC Sequence=BAA92629.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAF84979.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAF84979.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/ARHGAP20ID42979ch11q23.html";
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DR EMBL; AY496263; AAS45466.1; -; mRNA.
DR EMBL; AY496264; AAS45467.1; -; mRNA.
DR EMBL; AY496265; AAS45468.1; -; mRNA.
DR EMBL; AY496266; AAS45469.1; -; mRNA.
DR EMBL; AY496267; AAS45470.1; -; mRNA.
DR EMBL; AB037812; BAA92629.1; ALT_INIT; mRNA.
DR EMBL; EF444953; ACA05945.1; -; Genomic_DNA.
DR EMBL; EF444953; ACA05946.1; -; Genomic_DNA.
DR EMBL; CH471065; EAW67134.1; -; Genomic_DNA.
DR EMBL; AK292290; BAF84979.1; ALT_SEQ; mRNA.
DR EMBL; BC039340; AAH39340.1; ALT_SEQ; mRNA.
DR CCDS; CCDS31673.1; -. [Q9P2F6-1]
DR CCDS; CCDS58175.1; -. [Q9P2F6-4]
DR CCDS; CCDS58176.1; -. [Q9P2F6-2]
DR CCDS; CCDS58177.1; -. [Q9P2F6-3]
DR PIR; C59436; C59436.
DR RefSeq; NP_001245344.1; NM_001258415.1. [Q9P2F6-3]
DR RefSeq; NP_001245345.1; NM_001258416.1. [Q9P2F6-2]
DR RefSeq; NP_001245346.1; NM_001258417.1. [Q9P2F6-4]
DR RefSeq; NP_001245347.1; NM_001258418.1. [Q9P2F6-4]
DR RefSeq; NP_065860.2; NM_020809.3. [Q9P2F6-1]
DR RefSeq; XP_006718956.1; XM_006718893.3.
DR PDB; 3MSX; X-ray; 1.65 A; B=351-551.
DR PDBsum; 3MSX; -.
DR AlphaFoldDB; Q9P2F6; -.
DR SMR; Q9P2F6; -.
DR BioGRID; 121622; 27.
DR IntAct; Q9P2F6; 12.
DR STRING; 9606.ENSP00000260283; -.
DR iPTMnet; Q9P2F6; -.
DR PhosphoSitePlus; Q9P2F6; -.
DR BioMuta; ARHGAP20; -.
DR DMDM; 143458429; -.
DR jPOST; Q9P2F6; -.
DR MassIVE; Q9P2F6; -.
DR PaxDb; Q9P2F6; -.
DR PeptideAtlas; Q9P2F6; -.
DR PRIDE; Q9P2F6; -.
DR ProteomicsDB; 83803; -. [Q9P2F6-1]
DR ProteomicsDB; 83804; -. [Q9P2F6-2]
DR ProteomicsDB; 83805; -. [Q9P2F6-3]
DR ProteomicsDB; 83806; -. [Q9P2F6-4]
DR Antibodypedia; 32015; 127 antibodies from 27 providers.
DR DNASU; 57569; -.
DR Ensembl; ENST00000260283.8; ENSP00000260283.4; ENSG00000137727.13. [Q9P2F6-1]
DR Ensembl; ENST00000524756.5; ENSP00000432076.1; ENSG00000137727.13. [Q9P2F6-3]
DR Ensembl; ENST00000527598.1; ENSP00000431399.1; ENSG00000137727.13. [Q9P2F6-4]
DR Ensembl; ENST00000528829.5; ENSP00000436319.1; ENSG00000137727.13. [Q9P2F6-4]
DR Ensembl; ENST00000533353.5; ENSP00000436522.1; ENSG00000137727.13. [Q9P2F6-2]
DR Ensembl; ENST00000683387.1; ENSP00000507405.1; ENSG00000137727.13. [Q9P2F6-1]
DR GeneID; 57569; -.
DR KEGG; hsa:57569; -.
DR MANE-Select; ENST00000683387.1; ENSP00000507405.1; NM_001384657.1; NP_001371586.1.
DR UCSC; uc001pky.3; human. [Q9P2F6-1]
DR CTD; 57569; -.
DR DisGeNET; 57569; -.
DR GeneCards; ARHGAP20; -.
DR HGNC; HGNC:18357; ARHGAP20.
DR HPA; ENSG00000137727; Low tissue specificity.
DR MIM; 609568; gene.
DR neXtProt; NX_Q9P2F6; -.
DR OpenTargets; ENSG00000137727; -.
DR PharmGKB; PA134963885; -.
DR VEuPathDB; HostDB:ENSG00000137727; -.
DR eggNOG; KOG4724; Eukaryota.
DR GeneTree; ENSGT00940000154633; -.
DR HOGENOM; CLU_008526_0_0_1; -.
DR InParanoid; Q9P2F6; -.
DR OrthoDB; 148399at2759; -.
DR PhylomeDB; Q9P2F6; -.
DR TreeFam; TF331062; -.
DR PathwayCommons; Q9P2F6; -.
DR Reactome; R-HSA-8980692; RHOA GTPase cycle.
DR Reactome; R-HSA-9013148; CDC42 GTPase cycle.
DR Reactome; R-HSA-9013149; RAC1 GTPase cycle.
DR SignaLink; Q9P2F6; -.
DR SIGNOR; Q9P2F6; -.
DR BioGRID-ORCS; 57569; 8 hits in 1070 CRISPR screens.
DR EvolutionaryTrace; Q9P2F6; -.
DR GenomeRNAi; 57569; -.
DR Pharos; Q9P2F6; Tbio.
DR PRO; PR:Q9P2F6; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9P2F6; protein.
DR Bgee; ENSG00000137727; Expressed in cortical plate and 157 other tissues.
DR ExpressionAtlas; Q9P2F6; baseline and differential.
DR Genevisible; Q9P2F6; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; SSF48350; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Chromosomal rearrangement;
KW GTPase activation; Phosphoprotein; Reference proteome; Tumor suppressor.
FT CHAIN 1..1191
FT /note="Rho GTPase-activating protein 20"
FT /id="PRO_0000283086"
FT DOMAIN 78..180
FT /note="PH"
FT DOMAIN 194..295
FT /note="Ras-associating"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00166"
FT DOMAIN 365..551
FT /note="Rho-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 768..791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 925..1014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1052..1123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1140..1191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 768..783
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 930..979
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 992..1013
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1053..1067
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1104..1123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1143..1172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 46
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6IFT4"
FT MOD_RES 704
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6IFT4"
FT MOD_RES 730
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6IFT4"
FT VAR_SEQ 1..36
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15543602"
FT /id="VSP_024296"
FT VAR_SEQ 1..34
FT /note="MEAMSPQQETLGGQPGRSSSLTGVSRLAGGSCTK -> MTFWIIIN (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15543602"
FT /id="VSP_024294"
FT VAR_SEQ 1..33
FT /note="MEAMSPQQETLGGQPGRSSSLTGVSRLAGGSCT -> MSARERQPAL (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:15543602"
FT /id="VSP_024295"
FT VARIANT 522
FT /note="A -> T (in dbSNP:rs7936020)"
FT /id="VAR_031489"
FT VARIANT 632
FT /note="G -> D (in dbSNP:rs17853925)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_031490"
FT HELIX 367..370
FT /evidence="ECO:0007829|PDB:3MSX"
FT HELIX 372..374
FT /evidence="ECO:0007829|PDB:3MSX"
FT HELIX 378..390
FT /evidence="ECO:0007829|PDB:3MSX"
FT HELIX 391..393
FT /evidence="ECO:0007829|PDB:3MSX"
FT TURN 395..399
FT /evidence="ECO:0007829|PDB:3MSX"
FT HELIX 404..415
FT /evidence="ECO:0007829|PDB:3MSX"
FT HELIX 427..439
FT /evidence="ECO:0007829|PDB:3MSX"
FT TURN 442..447
FT /evidence="ECO:0007829|PDB:3MSX"
FT HELIX 448..450
FT /evidence="ECO:0007829|PDB:3MSX"
FT HELIX 451..456
FT /evidence="ECO:0007829|PDB:3MSX"
FT HELIX 457..459
FT /evidence="ECO:0007829|PDB:3MSX"
FT STRAND 460..462
FT /evidence="ECO:0007829|PDB:3MSX"
FT HELIX 463..474
FT /evidence="ECO:0007829|PDB:3MSX"
FT HELIX 479..496
FT /evidence="ECO:0007829|PDB:3MSX"
FT HELIX 499..502
FT /evidence="ECO:0007829|PDB:3MSX"
FT HELIX 506..517
FT /evidence="ECO:0007829|PDB:3MSX"
FT HELIX 526..550
FT /evidence="ECO:0007829|PDB:3MSX"
SQ SEQUENCE 1191 AA; 132608 MW; 1837B9DF0655AF41 CRC64;
MEAMSPQQET LGGQPGRSSS LTGVSRLAGG SCTKKKMKTL AERRRSAPSL ILDKALQKRP
TTRDSPSASV DTCTFLSSLV CSNRTLLIDG RAELKRGLQR QERHLFLFND LFVVAKIKYN
NNFKIKNKIK LTDMWTASCV DEVGEGNTNA MKSFVLGWPT VNFVATFSSP EQKDKWLSLL
QRYINLEKEK DYPKSIPLKI FAKDIGNCAY SKTITVMNSD TANEVINMSL PMLGITGSER
DYQLWVNSGK EEAPYPLIGH EYPYGIKMSH LRDSALLTPG SKDSTTPFNL QEPFLMEQLP
REMQCQFILK PSRLAAAQQL SDSGHKTFKR RRSIINWAFW RGSSTHLDNL PSSPTSPMPG
QLFGISLPNI CENDNLPKPV LDMLFFLNQK GPLTKGIFRQ SANVKSCREL KEKLNSGVEV
HLDCESIFVI ASVLKDFLRN IPGSIFSSDL YDHWVSVMDQ GNDEEKINTV QRLLDQLPRA
NVVLLRYLFG VLHNIEQHSS SNQMTAFNLA VCVAPSILWP PASSSPELEN EFTKKVSLLI
QFLIENCLRI FGEEITSLFR EVSVRCDTRE NASDISCFQL NDSSYDSLEN ELNEDVDAPC
SDLVKKLGQG SRSMDSVLTL SDYDLDQPEV EGLLTLSDFD LAHSKDEDVQ MKRPLESKPV
NILVYTKIPL RDHARAPSAM CTPSYLSTAA ANAAKSLRRH RRCSEPSIDY LDSKLSYLRE
FYQKKLRKSS CDAILSQKDE DYLKQNQPLQ EEGKTCFKQS LVTGTDVSKK NATTQNTKKK
SLSGSEGNHV KLFPKSKPVA ISVASYSPMS SQDHSKNQPF DVNTSGYSPP HTADALKGPR
THRRCSEPNI EDQNRKLTYL RGIYSKKQHK TSCEAGLLHG EEDYLKRHKS LQMEGQKLIN
QSLVMGIEVG KSSATNQNTE KVLPPRLNLC PRTSYSSLSS PGTSPSGSSV SSQDSAFSQI
SEHSVFTPTE TSSPIDCTFQ AQRKREDLSP DFSNASHVSG MPGPSSGQAC SRPAYTKKDT
MEWHSQMHSV TLHPSTWLRN GVASLKNWSL KKKAKAARPE EEKIASPKGP LEPPPHASGV
PEANSLQEEQ KDLPLRAAEG LSPVQSAQRC SSSPFQDSER HCSSPFSLVE SRLKLCMKSH
EEIEPGSQSS SGSLPWERAS ASSWTLEDAT SPDSGPTVVC DIEDRYLTKD I
