ID   RGA6_SCHPO              Reviewed;         733 AA.
AC   O43027;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Probable Rho-GTPase-activating protein 6;
GN   Name=rga6; ORFNames=SPBC354.13;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-141, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RX   PubMed=18257517; DOI=10.1021/pr7006335;
RA   Wilson-Grady J.T., Villen J., Gygi S.P.;
RT   "Phosphoproteome analysis of fission yeast.";
RL   J. Proteome Res. 7:1088-1097(2008).
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DR   EMBL; CU329671; CAA17813.1; -; Genomic_DNA.
DR   PIR; T40293; T40293.
DR   RefSeq; NP_595237.1; NM_001021143.2.
DR   AlphaFoldDB; O43027; -.
DR   SMR; O43027; -.
DR   BioGRID; 276834; 22.
DR   STRING; 4896.SPBC354.13.1; -.
DR   iPTMnet; O43027; -.
DR   MaxQB; O43027; -.
DR   PaxDb; O43027; -.
DR   PRIDE; O43027; -.
DR   EnsemblFungi; SPBC354.13.1; SPBC354.13.1:pep; SPBC354.13.
DR   GeneID; 2540304; -.
DR   KEGG; spo:SPBC354.13; -.
DR   PomBase; SPBC354.13; rga6.
DR   VEuPathDB; FungiDB:SPBC354.13; -.
DR   eggNOG; ENOG502SAYM; Eukaryota.
DR   HOGENOM; CLU_372617_0_0_1; -.
DR   InParanoid; O43027; -.
DR   Reactome; R-SPO-8980692; RHOA GTPase cycle.
DR   Reactome; R-SPO-9013026; RHOB GTPase cycle.
DR   Reactome; R-SPO-9013106; RHOC GTPase cycle.
DR   Reactome; R-SPO-9013148; CDC42 GTPase cycle.
DR   Reactome; R-SPO-9013405; RHOD GTPase cycle.
DR   Reactome; R-SPO-9035034; RHOF GTPase cycle.
DR   PRO; PR:O43027; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0032153; C:cell division site; IDA:PomBase.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0097575; C:lateral cell cortex; IDA:PomBase.
DR   GO; GO:0035839; C:non-growing cell tip; IDA:PomBase.
DR   GO; GO:0005096; F:GTPase activator activity; IDA:PomBase.
DR   GO; GO:0031267; F:small GTPase binding; IPI:PomBase.
DR   GO; GO:0060305; P:regulation of cell diameter; IMP:PomBase.
DR   GO; GO:0032878; P:regulation of establishment or maintenance of cell polarity; EXP:PomBase.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IBA:GO_Central.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   1: Evidence at protein level;
KW   GTPase activation; Phosphoprotein; Reference proteome.
FT   CHAIN           1..733
FT                   /note="Probable Rho-GTPase-activating protein 6"
FT                   /id="PRO_0000097314"
FT   DOMAIN          312..546
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT   REGION          116..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          174..256
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          692..713
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        181..256
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         141
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
SQ   SEQUENCE   733 AA;  80777 MW;  4AADAEE855D81CE9 CRC64;
     MTLNPSTLNN GTLGDLKEHK DVVLSSNAQT DEKRFEEPSL EVGGSLAKVE NGLSTSISSS
     ASNLEGQQAP FFTKQNSCLS RFRELAQTYN IHEINLEEYV SQIKEVKQSL YSDDSVFNES
     KSSSPPDAHT DKYFTPCGSP TKLIHSTLLE ERDTPSSLEH VSFYLQESAV SEVRFDKPSN
     NGPLGRSSLN LSSLSHELQT SQDSPSLSAT NQLSSSDTLE PLQYPPSSFG SQRQFNASQD
     SPKRSPSKGS WSSILRRPSL TYSPKRQSTG LHRRSLTNYF KFPHRNAHQH NAIAHNPSVF
     GKPIGDLTSD PTNLCKFTFP TPECAPPSLL LPHIFAQCVH FLSLNALHVP GIFRISGSGP
     VIKAITEYFY SPPHFWLDET SEIFKRIGFP SYIDIAAVLK RYIMLLPGGL FTHKDILNLL
     VPLYVDSSRV KVPIDIRNEM AALCFSQIDS YVRFSILCSL LALLHQIATR TQELENGMEN
     TKDSTLMKPE ALGIIFGPLL LGNSSTDLSK SCPSGNVNDL MRFETEKARV EAKIVEGLII
     HWPEVLLKIN SLDIPNCFSD VGLTDQVAIF TPAVPKEDSP EQIPENVNAS EESYPNVKHI
     SKLPLINDSS DNESGNQEND DAVANESTKV VVDNQQPQPK ISTVSDTAVP SMSFANNISS
     RSVISAATDS KPSTRTSPPF VNNTKPIVAK SPVTVTASSE TNKKSQKINK KASPRVSLWT
     KLFGKFRSNK KKS