RFOX1_PONAB
ID RFOX1_PONAB Reviewed; 382 AA.
AC Q5NVN8; Q5R948;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=RNA binding protein fox-1 homolog 1;
DE AltName: Full=Ataxin-2-binding protein 1;
DE AltName: Full=Fox-1 homolog A;
GN Name=RBFOX1; Synonyms=A2BP1, FOX1;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: RNA-binding protein that regulates alternative splicing
CC events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2
CC to the 3'-splice site. Regulates alternative splicing of tissue-
CC specific exons and of differentially spliced exons during
CC erythropoiesis (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Binds to the C-terminus of ATXN2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5NVN8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5NVN8-2; Sequence=VSP_030885, VSP_030886;
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DR EMBL; CR859547; CAH91712.1; -; mRNA.
DR EMBL; CR925977; CAI29625.1; -; mRNA.
DR RefSeq; NP_001125995.1; NM_001132523.1.
DR AlphaFoldDB; Q5NVN8; -.
DR BMRB; Q5NVN8; -.
DR SMR; Q5NVN8; -.
DR STRING; 9601.ENSPPYP00000008003; -.
DR GeneID; 100172936; -.
DR KEGG; pon:100172936; -.
DR CTD; 54715; -.
DR eggNOG; KOG0125; Eukaryota.
DR InParanoid; Q5NVN8; -.
DR OrthoDB; 871288at2759; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0043484; P:regulation of RNA splicing; IEA:InterPro.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd12407; RRM_FOX1_like; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR025670; Fox-1_C_dom.
DR InterPro; IPR034237; FOX1_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR017325; RNA-bd_Fox-1.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF12414; Fox-1_C; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF037932; Ataxin_2_bd_A2BP; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Methylation; mRNA processing;
KW mRNA splicing; Nucleus; Reference proteome; RNA-binding.
FT CHAIN 1..382
FT /note="RNA binding protein fox-1 homolog 1"
FT /id="PRO_0000317111"
FT DOMAIN 117..193
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 1..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 357..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 118
FT /note="Interaction with RNA"
FT /evidence="ECO:0000250"
FT SITE 126
FT /note="Interaction with RNA"
FT /evidence="ECO:0000250"
FT SITE 127
FT /note="Interaction with RNA"
FT /evidence="ECO:0000250"
FT SITE 151
FT /note="Interaction with RNA"
FT /evidence="ECO:0000250"
FT SITE 156
FT /note="Interaction with RNA"
FT /evidence="ECO:0000250"
FT SITE 160
FT /note="Interaction with RNA"
FT /evidence="ECO:0000250"
FT SITE 184
FT /note="Interaction with RNA"
FT /evidence="ECO:0000250"
FT SITE 194
FT /note="Interaction with RNA"
FT /evidence="ECO:0000250"
FT MOD_RES 317
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q9JJ43"
FT VAR_SEQ 1
FT /note="M -> METGQRTHASGTYSFLDRTQHSDIKADCSTCVEIEDRKVSRQQM
FT (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_030885"
FT VAR_SEQ 332..382
FT /note="SYGRVYAADPYHHALAPAPTYGVGAMPQGSSPSTDFRGAKLHTSRPLLSGS
FT -> RNQFVFVAADEISCNTSAVTDEFMLPTPTTTHLLQPPPTALVPCPKVPAPAQTSEE
FT LSCTLPGLCCQAAENLTASPPLLQFMFKVIVAQERK (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_030886"
FT CONFLICT 152
FT /note="E -> G (in Ref. 1; CAH91712)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 382 AA; 41024 MW; 5832284AA1B2C006 CRC64;
MNCEREQLRG NQEAAAAPDT MAQPYASAQF APPQNGIPAE YTAPHPHPAP EYTGQTTVPE
HTLNLYPPAQ THSEQSPADT SAQTVSGTAT QTDDAAPTDG QPQTQPSENT ENKSQPKRLH
VSNIPFRFRD PDLRQMFGQF GKILDVEIIF NERGSKGFGF VTFENSADAD RAREKLHGTV
VEGRKIEVNN ATARVMTNKK TVNPYTNGWK LNPVVGAVYS PEFYAGTVLL CQANQEGSSM
YSAPSSLVYT SAMPGFPYPA ATAAAAYRGA HLRGRGRTVY NTFRAAAPPP PIPAYGGVVY
QDGFYGADIY GGYAAYRYAQ PTPATAAAYS DSYGRVYAAD PYHHALAPAP TYGVGAMPQG
SSPSTDFRGA KLHTSRPLLS GS
