ID   REX_STRPN               Reviewed;         213 AA.
AC   Q97QV8;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Redox-sensing transcriptional repressor Rex {ECO:0000255|HAMAP-Rule:MF_01131};
GN   Name=rex {ECO:0000255|HAMAP-Rule:MF_01131}; OrderedLocusNames=SP_1090;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- FUNCTION: Modulates transcription in response to changes in cellular
CC       NADH/NAD(+) redox state. {ECO:0000255|HAMAP-Rule:MF_01131}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01131}.
CC   -!- INTERACTION:
CC       Q97QV8; Q97SE5: gatC; NbExp=2; IntAct=EBI-2207177, EBI-2207053;
CC       Q97QV8; Q97NV3: groES; NbExp=2; IntAct=EBI-2207177, EBI-2206949;
CC       Q97QV8; P0A4S9: SP_1877; NbExp=2; IntAct=EBI-2207177, EBI-2207382;
CC       Q97QV8; Q97SR4: uppS; NbExp=2; IntAct=EBI-2207177, EBI-2206983;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01131}.
CC   -!- SIMILARITY: Belongs to the transcriptional regulatory Rex family.
CC       {ECO:0000255|HAMAP-Rule:MF_01131}.
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DR   EMBL; AE005672; AAK75202.1; -; Genomic_DNA.
DR   PIR; A95126; A95126.
DR   RefSeq; WP_000653403.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; Q97QV8; -.
DR   SMR; Q97QV8; -.
DR   IntAct; Q97QV8; 4.
DR   STRING; 170187.SP_1090; -.
DR   EnsemblBacteria; AAK75202; AAK75202; SP_1090.
DR   GeneID; 66806196; -.
DR   KEGG; spn:SP_1090; -.
DR   eggNOG; COG2344; Bacteria.
DR   OMA; HEQRKAG; -.
DR   PhylomeDB; Q97QV8; -.
DR   BioCyc; SPNE170187:G1FZB-1119-MON; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0051775; P:response to redox state; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01131; Rex; 1.
DR   InterPro; IPR003781; CoA-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR009718; Rex_DNA-bd_C_dom.
DR   InterPro; IPR022876; Tscrpt_rep_Rex.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR35786; PTHR35786; 1.
DR   Pfam; PF02629; CoA_binding; 1.
DR   Pfam; PF06971; Put_DNA-bind_N; 1.
DR   SMART; SM00881; CoA_binding; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; DNA-binding; NAD; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..213
FT                   /note="Redox-sensing transcriptional repressor Rex"
FT                   /id="PRO_0000097918"
FT   DNA_BIND        18..57
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01131"
FT   BINDING         92..97
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01131"
SQ   SEQUENCE   213 AA;  24165 MW;  26D4B17297A0AB94 CRC64;
     MKDKQFAIPK ATAKRLSLYY RIFKRFHAEK IERANSKQIA EAIGIDSATV RRDFSYFGEL
     GRRGFGYDVK KLMTFFADLL NDNSITNVML VGIGNMGHAL LHYRFHERNK MKIIMAFDLD
     DHPEVGTQTP DGIPIYGISQ IKDKIKDADV KTAILTVPSV KSQEVANLLV DAGVKGILSF
     SPVHLHLPKD VVVQYVDLTS ELQTLLYFMR KED