REX_STRA3
ID REX_STRA3 Reviewed; 212 AA.
AC Q8E565;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Redox-sensing transcriptional repressor Rex {ECO:0000255|HAMAP-Rule:MF_01131};
GN Name=rex {ECO:0000255|HAMAP-Rule:MF_01131}; OrderedLocusNames=gbs1167;
OS Streptococcus agalactiae serotype III (strain NEM316).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=211110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEM316;
RX PubMed=12354221; DOI=10.1046/j.1365-2958.2002.03126.x;
RA Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T.,
RA Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F.;
RT "Genome sequence of Streptococcus agalactiae, a pathogen causing invasive
RT neonatal disease.";
RL Mol. Microbiol. 45:1499-1513(2002).
CC -!- FUNCTION: Modulates transcription in response to changes in cellular
CC NADH/NAD(+) redox state. {ECO:0000255|HAMAP-Rule:MF_01131}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01131}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01131}.
CC -!- SIMILARITY: Belongs to the transcriptional regulatory Rex family.
CC {ECO:0000255|HAMAP-Rule:MF_01131}.
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DR EMBL; AL766849; CAD46826.1; -; Genomic_DNA.
DR PDB; 3KEO; X-ray; 1.50 A; A/B=1-212.
DR PDB; 3KEQ; X-ray; 2.40 A; A/B=1-212.
DR PDB; 3KET; X-ray; 2.40 A; A=1-212.
DR PDBsum; 3KEO; -.
DR PDBsum; 3KEQ; -.
DR PDBsum; 3KET; -.
DR AlphaFoldDB; Q8E565; -.
DR SMR; Q8E565; -.
DR STRING; 211110.gbs1167; -.
DR EnsemblBacteria; CAD46826; CAD46826; CAD46826.
DR KEGG; san:gbs1167; -.
DR eggNOG; COG2344; Bacteria.
DR HOGENOM; CLU_061534_1_1_9; -.
DR OMA; HEQRKAG; -.
DR EvolutionaryTrace; Q8E565; -.
DR Proteomes; UP000000823; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0051775; P:response to redox state; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_01131; Rex; 1.
DR InterPro; IPR003781; CoA-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR009718; Rex_DNA-bd_C_dom.
DR InterPro; IPR022876; Tscrpt_rep_Rex.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR35786; PTHR35786; 1.
DR Pfam; PF02629; CoA_binding; 1.
DR Pfam; PF06971; Put_DNA-bind_N; 1.
DR SMART; SM00881; CoA_binding; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; DNA-binding; NAD; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..212
FT /note="Redox-sensing transcriptional repressor Rex"
FT /id="PRO_0000097913"
FT DNA_BIND 17..56
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01131"
FT BINDING 91..96
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01131"
FT HELIX 9..12
FT /evidence="ECO:0007829|PDB:3KEO"
FT HELIX 15..27
FT /evidence="ECO:0007829|PDB:3KEO"
FT HELIX 35..42
FT /evidence="ECO:0007829|PDB:3KEO"
FT HELIX 46..54
FT /evidence="ECO:0007829|PDB:3KEO"
FT HELIX 55..59
FT /evidence="ECO:0007829|PDB:3KEO"
FT TURN 60..62
FT /evidence="ECO:0007829|PDB:3KEO"
FT STRAND 63..67
FT /evidence="ECO:0007829|PDB:3KEO"
FT HELIX 68..78
FT /evidence="ECO:0007829|PDB:3KEO"
FT TURN 79..82
FT /evidence="ECO:0007829|PDB:3KEO"
FT STRAND 85..90
FT /evidence="ECO:0007829|PDB:3KEO"
FT HELIX 94..99
FT /evidence="ECO:0007829|PDB:3KEO"
FT HELIX 104..106
FT /evidence="ECO:0007829|PDB:3KET"
FT STRAND 108..117
FT /evidence="ECO:0007829|PDB:3KEO"
FT TURN 122..125
FT /evidence="ECO:0007829|PDB:3KEO"
FT STRAND 133..136
FT /evidence="ECO:0007829|PDB:3KEO"
FT HELIX 137..139
FT /evidence="ECO:0007829|PDB:3KEO"
FT HELIX 140..143
FT /evidence="ECO:0007829|PDB:3KEO"
FT STRAND 145..147
FT /evidence="ECO:0007829|PDB:3KET"
FT STRAND 151..154
FT /evidence="ECO:0007829|PDB:3KEO"
FT HELIX 158..160
FT /evidence="ECO:0007829|PDB:3KEO"
FT HELIX 161..171
FT /evidence="ECO:0007829|PDB:3KEO"
FT STRAND 175..178
FT /evidence="ECO:0007829|PDB:3KEO"
FT STRAND 180..182
FT /evidence="ECO:0007829|PDB:3KEO"
FT STRAND 190..194
FT /evidence="ECO:0007829|PDB:3KEO"
FT HELIX 197..211
FT /evidence="ECO:0007829|PDB:3KEO"
SQ SEQUENCE 212 AA; 23821 MW; D787577314A7B7F3 CRC64;
MIMDKSIPKA TAKRLSLYYR IFKRFNTDGI EKASSKQIAD ALGIDSATVR RDFSYFGELG
RRGFGYDVKK LMNFFAEILN DHSTTNVMLV GCGNIGRALL HYRFHDRNKM QISMAFDLDS
NDLVGKTTED GIPVYGISTI NDHLIDSDIE TAILTVPSTE AQEVADILVK AGIKGILSFS
PVHLTLPKDI IVQYVDLTSE LQTLLYFMNQ QR
