ID   REI2_CAEEL              Reviewed;         431 AA.
AC   Q21194;
DT   17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 2.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Guanine nucleotide exchange factor rei-2 {ECO:0000305};
GN   Name=rei-2 {ECO:0000312|WormBase:K03E6.7};
GN   ORFNames=K03E6.7 {ECO:0000312|WormBase:K03E6.7};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|EMBL:CCD62865.1,
RC   ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   FUNCTION, INTERACTION WITH RAB-11.1, DEVELOPMENTAL STAGE, AND DISRUPTION
RP   PHENOTYPE.
RX   PubMed=26506309; DOI=10.1016/j.devcel.2015.09.013;
RA   Sakaguchi A., Sato M., Sato K., Gengyo-Ando K., Yorimitsu T., Nakai J.,
RA   Hara T., Sato K., Sato K.;
RT   "REI-1 is a guanine nucleotide exchange factor regulating RAB-11
RT   localization and function in C. elegans embryos.";
RL   Dev. Cell 35:211-221(2015).
CC   -!- FUNCTION: Guanine nucleotide exchange factor for Rab GTPase Rab-11.1
CC       (By similarity). May spatially and temporally regulate the distribution
CC       of Rab-11.1 to target membranes during embryogenesis (PubMed:26506309).
CC       May play a role in cytokinesis, probably by targeting rab-11.1 to the
CC       cleavage furrows (PubMed:26506309). {ECO:0000250|UniProtKB:P42171,
CC       ECO:0000269|PubMed:26506309}.
CC   -!- SUBUNIT: Interacts with rab-11.1. Binds preferentially to the GDP-bound
CC       form of rab-11.1. {ECO:0000269|PubMed:26506309}.
CC   -!- DEVELOPMENTAL STAGE: Expressed during embryogenesis.
CC       {ECO:0000269|PubMed:26506309}.
CC   -!- DISRUPTION PHENOTYPE: Viable. Double knockout with rei-1 results in a
CC       smaller brood size, weak embryonic lethality and severe mislocalization
CC       of rab-11.1 and prolonged cytokinesis in embryos.
CC       {ECO:0000269|PubMed:26506309}.
CC   -!- SIMILARITY: Belongs to the SH3BP5 family. {ECO:0000305}.
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DR   EMBL; BX284606; CCD62865.1; -; Genomic_DNA.
DR   PIR; T34328; T34328.
DR   RefSeq; NP_508206.2; NM_075805.4.
DR   AlphaFoldDB; Q21194; -.
DR   SMR; Q21194; -.
DR   STRING; 6239.K03E6.7; -.
DR   EPD; Q21194; -.
DR   PaxDb; Q21194; -.
DR   PeptideAtlas; Q21194; -.
DR   EnsemblMetazoa; K03E6.7.1; K03E6.7.1; WBGene00019365.
DR   GeneID; 180461; -.
DR   KEGG; cel:CELE_K03E6.7; -.
DR   UCSC; K03E6.7.1; c. elegans.
DR   CTD; 180461; -.
DR   WormBase; K03E6.7; CE31197; WBGene00019365; rei-2.
DR   eggNOG; KOG2008; Eukaryota.
DR   GeneTree; ENSGT00390000018500; -.
DR   HOGENOM; CLU_649313_0_0_1; -.
DR   InParanoid; Q21194; -.
DR   OMA; DFRYRTE; -.
DR   OrthoDB; 871798at2759; -.
DR   PhylomeDB; Q21194; -.
DR   PRO; PR:Q21194; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00019365; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004860; F:protein kinase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR   GO; GO:0061099; P:negative regulation of protein tyrosine kinase activity; IBA:GO_Central.
DR   InterPro; IPR007940; SH3BP5.
DR   PANTHER; PTHR19423; PTHR19423; 1.
DR   Pfam; PF05276; SH3BP5; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Coiled coil; GTP-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..431
FT                   /note="Guanine nucleotide exchange factor rei-2"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000435467"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          249..298
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          149..171
FT                   /evidence="ECO:0000255"
FT   COILED          214..247
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   431 AA;  48935 MW;  BE4CAB8D47970EB7 CRC64;
     MDETATSSEV TETFVSDPTT RQFEEDGHPP LETRHLNMIH EELEKLNIST DVINKMEVQL
     DLARADFRET QVQWSEKLKE LSKQYSSQIA KARPFYELKI KERSLREESQ KAAERFERAT
     SILGIAKQQV SLTQESLSRQ TSVLPECLEV LNHHIQRVRE VEEERTAAES LHASKAHAML
     HLAEKIRAME KDNRYAIKKS RLYFEKRLEF TKILEAQKAT ILCLEAEVRQ KKNDYTTSLR
     NLERISERIH EERSTGSLES AVSSDQEDQK SDFKSSESLP GNPPPYAPTA PPPYEDKYII
     DKDDDSIVLN MIKTEQEEEG EKRNSRSLGS GVILLAQQLI GNGNSTEKHN ITPPRHGEEA
     DISYHTRPVG LSDGSDNSEV SSLASFNIGD DDTVSKMLMS HSELIKDIEL ATDRVGHILK
     PNIKSVSNAH E