ID   RDXA_HELPJ              Reviewed;         210 AA.
AC   Q9ZKP7;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Oxygen-insensitive NADPH nitroreductase;
DE            EC=1.-.-.-;
GN   Name=rdxA; OrderedLocusNames=jhp_0888;
OS   Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99 / ATCC 700824;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA   Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA   Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human gastric
RT   pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- FUNCTION: Reduction of a variety of nitroaromatic compounds using NADPH
CC       as source of reducing equivalents; two electrons are transferred.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nitroreductase family. {ECO:0000305}.
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DR   EMBL; AE001439; AAD06472.1; -; Genomic_DNA.
DR   PIR; A71876; A71876.
DR   RefSeq; WP_000670014.1; NZ_CP011330.1.
DR   AlphaFoldDB; Q9ZKP7; -.
DR   SMR; Q9ZKP7; -.
DR   STRING; 85963.jhp_0888; -.
DR   EnsemblBacteria; AAD06472; AAD06472; jhp_0888.
DR   KEGG; hpj:jhp_0888; -.
DR   PATRIC; fig|85963.30.peg.73; -.
DR   eggNOG; COG0778; Bacteria.
DR   OMA; EQCYIAV; -.
DR   Proteomes; UP000000804; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd02149; NfsB-like; 1.
DR   Gene3D; 3.40.109.10; -; 1.
DR   InterPro; IPR033878; NfsB-like.
DR   InterPro; IPR029479; Nitroreductase.
DR   InterPro; IPR000415; Nitroreductase-like.
DR   Pfam; PF00881; Nitroreductase; 1.
DR   SUPFAM; SSF55469; SSF55469; 1.
PE   3: Inferred from homology;
KW   NADP; Oxidoreductase.
FT   CHAIN           1..210
FT                   /note="Oxygen-insensitive NADPH nitroreductase"
FT                   /id="PRO_0000321867"
FT   BINDING         150..155
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   210 AA;  24056 MW;  C58CD02047A5351D CRC64;
     MKFLDHEKRR QLLNERHSCK MFDSHYEFSS TELEEIAEIA RLSPSSYNTQ PWHFVMVTNK
     DLKKQIAAHS YFNEEMIKSA SALMVVCSLK PSELLPTSHY MQNLYPESYK VRVIPSFAQM
     LGVRFNHSMQ KLESYILEQC YIAVGQICMG VSLMGLDSCI IGGFDPLKVG EILEERINKP
     KIVCLIALGK RVAEASKKSR KSKVDAITWL