ID   RCSA_ECOLX              Reviewed;         207 AA.
AC   P0DMD0; P24210; P69405; Q47585;
DT   19-FEB-2014, integrated into UniProtKB/Swiss-Prot.
DT   19-FEB-2014, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Transcriptional regulatory protein RcsA {ECO:0000255|HAMAP-Rule:MF_00982};
GN   Name=rcsA {ECO:0000255|HAMAP-Rule:MF_00982};
OS   Escherichia coli.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION IN CAPSULAR POLYSACCHARIDE
RP   SYNTHESIS.
RC   STRAIN=O9:K30:H12;
RX   PubMed=1729226; DOI=10.1128/jb.174.1.8-16.1992;
RA   Keenleyside W.J., Jayaratne P., MacLachlan P.R., Whitfield C.;
RT   "The rcsA gene of Escherichia coli 09:K30:H12 is involved in the expression
RT   of the serotype-specific group I K (capsular) antigen.";
RL   J. Bacteriol. 174:8-16(1992).
CC   -!- FUNCTION: Component of the Rcs signaling system, which controls
CC       transcription of numerous genes. Binds, with RcsB, to the RcsAB box to
CC       regulate expression of genes (By similarity). Involved in regulation of
CC       K30 capsular polysaccharide synthesis. {ECO:0000255|HAMAP-
CC       Rule:MF_00982, ECO:0000269|PubMed:1729226}.
CC   -!- SUBUNIT: Interacts with RcsB. {ECO:0000255|HAMAP-Rule:MF_00982}.
CC   -!- SIMILARITY: Belongs to the RcsA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00982}.
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DR   EMBL; M81191; AAA24502.1; -; Genomic_DNA.
DR   RefSeq; WP_000103987.1; NZ_WVVZ01000023.1.
DR   AlphaFoldDB; P0DMD0; -.
DR   SMR; P0DMD0; -.
DR   STRING; 585034.ECIAI1_2032; -.
DR   GeneID; 66674159; -.
DR   eggNOG; COG2197; Bacteria.
DR   OMA; ANIHFDE; -.
DR   OrthoDB; 1687028at2; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_00982; RcsA; 1.
DR   InterPro; IPR030866; RcsA.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00196; GerE; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   PROSITE; PS00622; HTH_LUXR_1; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Sensory transduction; Transcription; Transcription regulation.
FT   CHAIN           1..207
FT                   /note="Transcriptional regulatory protein RcsA"
FT                   /id="PRO_0000425452"
FT   DOMAIN          131..196
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00982"
FT   DNA_BIND        155..174
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00982"
SQ   SEQUENCE   207 AA;  23521 MW;  70684B16002FD395 CRC64;
     MSTIIMDLCS YTRLGLTGYL LSRGVKKREI NDIETVDDLA IACDSQRPSV VFINEDCFIH
     DASNSQHIKH IINQHPNTLF IVFMAIANVH FDEYLLVRKN LLISSKSIKP ESLDDILGDI
     LKKETTITSF LNMPTLSLSR TESSMLRMWM AGQGTIQISD QMNIKAKTVS SHKGNIKRKI
     KTHNKQVIYH VVRLTDNVTN GIFVNMR