ID   RCSA_ECO57              Reviewed;         207 AA.
AC   P69406; P24210; Q47585;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Transcriptional regulatory protein RcsA {ECO:0000255|HAMAP-Rule:MF_00982};
GN   Name=rcsA {ECO:0000255|HAMAP-Rule:MF_00982};
GN   OrderedLocusNames=Z3041, ECs2690;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Component of the Rcs signaling system, which controls
CC       transcription of numerous genes. Binds, with RcsB, to the RcsAB box to
CC       regulate expression of genes. {ECO:0000255|HAMAP-Rule:MF_00982}.
CC   -!- SUBUNIT: Interacts with RcsB. {ECO:0000255|HAMAP-Rule:MF_00982}.
CC   -!- SIMILARITY: Belongs to the RcsA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00982}.
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DR   EMBL; AE005174; AAG56966.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB36113.1; -; Genomic_DNA.
DR   PIR; B85813; B85813.
DR   PIR; B90965; B90965.
DR   RefSeq; NP_310717.1; NC_002695.1.
DR   RefSeq; WP_000104001.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P69406; -.
DR   SMR; P69406; -.
DR   STRING; 155864.EDL933_2959; -.
DR   EnsemblBacteria; AAG56966; AAG56966; Z3041.
DR   EnsemblBacteria; BAB36113; BAB36113; ECs_2690.
DR   GeneID; 913009; -.
DR   KEGG; ece:Z3041; -.
DR   KEGG; ecs:ECs_2690; -.
DR   PATRIC; fig|386585.9.peg.2818; -.
DR   eggNOG; COG2197; Bacteria.
DR   HOGENOM; CLU_105065_0_0_6; -.
DR   OMA; ANIHFDE; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_00982; RcsA; 1.
DR   InterPro; IPR030866; RcsA.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00196; GerE; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   PROSITE; PS00622; HTH_LUXR_1; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Sensory transduction; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..207
FT                   /note="Transcriptional regulatory protein RcsA"
FT                   /id="PRO_0000184179"
FT   DOMAIN          131..196
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00982"
FT   DNA_BIND        155..174
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00982"
SQ   SEQUENCE   207 AA;  23516 MW;  6DAA22097807AF62 CRC64;
     MSTIIMDLCS YTRLGLTGYL LSRGVKKREI NDIETVDDLA IACDSQRPSV VFINEDCFIH
     DASNSQRIKL IINQHPNTLF IVFMAIANVH FDEYLLVRKN LLISSKSIKP ESLDDILGDI
     LKKETTITSF LNMPTLSLSR TESSMLRMWM AGQGTIQISD QMNIKAKTVS SHKGNIKRKI
     KTHNKQVIYH VVRLTDNVTN GIFVNMR