RCORA_CAEEL
ID RCORA_CAEEL Reviewed; 564 AA.
AC Q95Y41; H2KZI1; V6CK76; V6CLK9;
DT 25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=REST corepressor rcor-1 {ECO:0000303|PubMed:26476455};
GN Name=rcor-1 {ECO:0000312|WormBase:Y74C9A.4b};
GN ORFNames=Y74C9A.4 {ECO:0000312|WormBase:Y74C9A.4b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, AND INTERACTION WITH HPL-1.
RX PubMed=26476455; DOI=10.1093/nar/gkv1063;
RA Vandamme J., Sidoli S., Mariani L., Friis C., Christensen J., Helin K.,
RA Jensen O.N., Salcini A.E.;
RT "H3K23me2 is a new heterochromatic mark in Caenorhabditis elegans.";
RL Nucleic Acids Res. 43:9694-9710(2015).
CC -!- FUNCTION: Probable corepressor protein acting as a component of a
CC complex that represses transcription (Probable). May play a role, as
CC part of a CoREST-like complex, together with the chromobox protein
CC homologs hpl-1 and hpl-2, in the formation of the vulva and in
CC fertility (PubMed:26476455). {ECO:0000269|PubMed:26476455,
CC ECO:0000305|PubMed:26476455}.
CC -!- SUBUNIT: May be a component of a CoREST-like complex (PubMed:26476455).
CC May interact with chromobox protein homolog hpl-1 (PubMed:26476455).
CC {ECO:0000269|PubMed:26476455, ECO:0000303|PubMed:26476455}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512,
CC ECO:0000255|PROSITE-ProRule:PRU00624}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=b {ECO:0000312|WormBase:Y74C9A.4b};
CC IsoId=Q95Y41-1; Sequence=Displayed;
CC Name=a {ECO:0000312|WormBase:Y74C9A.4a};
CC IsoId=Q95Y41-2; Sequence=VSP_061505;
CC Name=c {ECO:0000312|WormBase:Y74C9A.4c};
CC IsoId=Q95Y41-3; Sequence=VSP_061504;
CC Name=d {ECO:0000312|WormBase:Y74C9A.4d};
CC IsoId=Q95Y41-4; Sequence=VSP_061503;
CC -!- SIMILARITY: Belongs to the CoREST family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX284601; CCD68264.1; -; Genomic_DNA.
DR EMBL; BX284601; CCD68265.1; -; Genomic_DNA.
DR EMBL; BX284601; CDK13439.1; -; Genomic_DNA.
DR EMBL; BX284601; CDK13440.1; -; Genomic_DNA.
DR RefSeq; NP_001293207.1; NM_001306278.1.
DR RefSeq; NP_001293208.1; NM_001306279.1.
DR RefSeq; NP_490662.1; NM_058261.4.
DR RefSeq; NP_490663.1; NM_058262.4.
DR AlphaFoldDB; Q95Y41; -.
DR STRING; 6239.Y74C9A.4b; -.
DR EPD; Q95Y41; -.
DR PaxDb; Q95Y41; -.
DR PeptideAtlas; Q95Y41; -.
DR EnsemblMetazoa; Y74C9A.4a.1; Y74C9A.4a.1; WBGene00022278. [Q95Y41-2]
DR EnsemblMetazoa; Y74C9A.4b.1; Y74C9A.4b.1; WBGene00022278. [Q95Y41-1]
DR EnsemblMetazoa; Y74C9A.4c.1; Y74C9A.4c.1; WBGene00022278. [Q95Y41-3]
DR EnsemblMetazoa; Y74C9A.4d.1; Y74C9A.4d.1; WBGene00022278. [Q95Y41-4]
DR GeneID; 171592; -.
DR KEGG; cel:CELE_Y74C9A.4; -.
DR UCSC; Y74C9A.4b; c. elegans. [Q95Y41-1]
DR CTD; 171592; -.
DR WormBase; Y74C9A.4a; CE24662; WBGene00022278; rcor-1.
DR WormBase; Y74C9A.4b; CE28147; WBGene00022278; rcor-1.
DR WormBase; Y74C9A.4c; CE49153; WBGene00022278; rcor-1.
DR WormBase; Y74C9A.4d; CE49439; WBGene00022278; rcor-1.
DR eggNOG; KOG1194; Eukaryota.
DR GeneTree; ENSGT00970000196447; -.
DR HOGENOM; CLU_485053_0_0_1; -.
DR InParanoid; Q95Y41; -.
DR OMA; FYYEMRE; -.
DR OrthoDB; 641792at2759; -.
DR Reactome; R-CEL-3214815; HDACs deacetylate histones.
DR Reactome; R-CEL-983231; Factors involved in megakaryocyte development and platelet production.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00022278; Expressed in adult organism and 4 other tissues.
DR ExpressionAtlas; Q95Y41; baseline and differential.
DR GO; GO:0000118; C:histone deacetylase complex; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0016575; P:histone deacetylation; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00167; SANT; 1.
DR InterPro; IPR000949; ELM2_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR InterPro; IPR000679; Znf_GATA.
DR SMART; SM01189; ELM2; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS51156; ELM2; 1.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
DR PROSITE; PS51293; SANT; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..564
FT /note="REST corepressor rcor-1"
FT /id="PRO_0000455615"
FT DOMAIN 109..190
FT /note="ELM2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00512"
FT DOMAIN 191..242
FT /note="SANT 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT DOMAIN 497..548
FT /note="SANT 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT ZN_FING 275..299
FT /note="GATA-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT REGION 1..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..66
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..86
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..290
FT /note="Missing (in isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_061503"
FT VAR_SEQ 1..31
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_061504"
FT VAR_SEQ 17..19
FT /note="Missing (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_061505"
SQ SEQUENCE 564 AA; 65919 MW; 43B93DCD56E365AE CRC64;
MDSYTSSDED ASRKENISDE GLNMLNASPE PMEEDDPEEQ AEQEEETSRM ARPIRSMRKR
ETTSGESMGD EDEDLEDEED EDEEAEAREH HESGAHDTSF SNPLSNVDNL IHVGTEYQAI
IQPTAEQLEK EPCRDQQIWA FPDEMNENRL TEYISEATGR YQLPIDRALF ILNKQSNDFD
AAMVQAMRRK EIHDDWTAEE ISLFSTCFFH FGKRFKKIHA AMPQRSLSSI IQYYYNTKKV
QNYKTMINVH LNETDTYDEL FKEVNHLERV PSGYCENCNA KSDLLILNRV MSRHECKPCI
LYFRLMRVPR PASLRALTKR RQRVLCPEYM KIYVYGYLEL MEPANGKAIK RLGIGKEKEE
DDDIMVVDDC LLRKPSGPYI VEQSIEADPI DENTCRMTRC FDTPAALALI DNIKRKHHMC
VPLVWRVKQT KCMEENEILN EEARQQMFRA TMTYSRVPKG EIANWKKDMM ALKGRFERFT
PELDTTATNG NRSGKVRINY GWSPEEKKNA IRCFHWYKDN FELIAELMAT KTVEQIKKFY
MDNEKLILES IDTYRAELKS KLGK
