RCOR3_CHICK
ID RCOR3_CHICK Reviewed; 378 AA.
AC Q5ZJ40;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=REST corepressor 3;
GN Name=RCOR3; ORFNames=RCJMB04_20o23;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: May act as a component of a corepressor complex that
CC represses transcription. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512,
CC ECO:0000255|PROSITE-ProRule:PRU00624}.
CC -!- SIMILARITY: Belongs to the CoREST family. {ECO:0000305}.
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DR EMBL; AJ720594; CAG32253.1; -; mRNA.
DR RefSeq; NP_001073195.1; NM_001079727.1.
DR AlphaFoldDB; Q5ZJ40; -.
DR SMR; Q5ZJ40; -.
DR STRING; 9031.ENSGALP00000016032; -.
DR PaxDb; Q5ZJ40; -.
DR GeneID; 421380; -.
DR KEGG; gga:421380; -.
DR CTD; 55758; -.
DR VEuPathDB; HostDB:geneid_421380; -.
DR eggNOG; KOG1194; Eukaryota.
DR InParanoid; Q5ZJ40; -.
DR OrthoDB; 641792at2759; -.
DR PhylomeDB; Q5ZJ40; -.
DR PRO; PR:Q5ZJ40; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0000118; C:histone deacetylase complex; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0016575; P:histone deacetylation; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR000949; ELM2_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR Pfam; PF01448; ELM2; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR SMART; SM01189; ELM2; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51156; ELM2; 1.
DR PROSITE; PS51293; SANT; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..378
FT /note="REST corepressor 3"
FT /id="PRO_0000226783"
FT DOMAIN 1..83
FT /note="ELM2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00512"
FT DOMAIN 84..135
FT /note="SANT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT REGION 147..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 238..273
FT /evidence="ECO:0000255"
FT COMPBIAS 166..184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 378 AA; 42409 MW; 609F53167A71DB8E CRC64;
MRVGAEYQAR IPDFEPGATK YTDKDNGGML VWSPYHNIPD AKLDEYIAIA KEKHGYNVEQ
ALGMLFWHKH NIEKSLADLP NFTPFPDEWT VEDKVLFEQA FSFHGKSFHR IQQMLPDKTI
ASLVKYYYSW KKTRSRTSLM DRQARKLANR NNQGDSDDDV EEPHPMDGND SDYDPKKEAK
KEGNNEQPVQ TSKIGLGRRE YQSLQHRHHS QRSKCRPPKG MYLTQEDVIA VSCSPNAANT
ILRRLDMELI SLKRQVQNAK QVNSALKQKM EGGIEEFKPP ESNQKINARW TTEEQLLAVQ
GAKHSDHSVF RPFTSSTGIC SSSHRSHSNF KSATPVTASS TSCCSCSPPS ASAAPTTGAI
YSAKANPKSA SPTAHPPS
