RCO3_NEUCR
ID RCO3_NEUCR Reviewed; 594 AA.
AC Q92253; Q7RVM6;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 2.
DT 25-MAY-2022, entry version 125.
DE RecName: Full=Probable glucose transporter rco-3;
GN Name=rco-3; ORFNames=B5K2.040, NCU02582;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=9178001; DOI=10.1093/genetics/146.2.499;
RA Madi L., McBride S.A., Bailey L.A., Ebbole D.J.;
RT "rco-3, a gene involved in glucose transport and conidiation in Neurospora
RT crassa.";
RL Genetics 146:499-508(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12655011; DOI=10.1093/nar/gkg293;
RA Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT genome sequence.";
RL Nucleic Acids Res. 31:1944-1954(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Probable glucose transporter. Involved in sugar transport,
CC carbon catabolite repression, and initiation of conidiophore
CC development.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; U54768; AAA99806.1; -; Genomic_DNA.
DR EMBL; BX842632; CAE76420.1; -; Genomic_DNA.
DR EMBL; CM002236; EAA36477.1; -; Genomic_DNA.
DR RefSeq; XP_965713.1; XM_960620.2.
DR AlphaFoldDB; Q92253; -.
DR SMR; Q92253; -.
DR STRING; 367110.Q92253; -.
DR EnsemblFungi; EAA36477; EAA36477; NCU02582.
DR GeneID; 3881863; -.
DR KEGG; ncr:NCU02582; -.
DR VEuPathDB; FungiDB:NCU02582; -.
DR HOGENOM; CLU_001265_30_1_1; -.
DR InParanoid; Q92253; -.
DR Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005351; F:carbohydrate:proton symporter activity; IBA:GO_Central.
DR GO; GO:0008643; P:carbohydrate transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Reference proteome; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..594
FT /note="Probable glucose transporter rco-3"
FT /id="PRO_0000050421"
FT TOPO_DOM 1..13
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 14..34
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 35..73
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 95..103
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 147..159
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 215..293
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 315..318
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 319..339
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 340..345
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 346..366
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 367..378
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 379..403
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 404..415
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 416..436
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 437..454
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 455..475
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 476..594
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 512..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..582
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 372
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 317
FT /note="F -> L (in Ref. 1; AAA99806)"
FT /evidence="ECO:0000305"
FT CONFLICT 376
FT /note="Q -> H (in Ref. 1; AAA99806)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 594 AA; 64626 MW; 7169AF184A5E9FE6 CRC64;
MAIFAMGWQK PDNVAGSSAP AIMVGLFVAT GGLLLGYDTG TINGILAMKS FKDHFSTGYI
DGNGQPGIYP KESALIVAML SAGTAIGALL AAPLGDHYGR RRSLIGAIGI FVIGAILQVC
AYNIDLLVAG RTVAGVGIGI VSVLVPLYQS EMAPKWIRGT LVCTYQLSIT MGLLAAAVVN
ILTYKLKTAA AYRVPIGLQL TWACVLALGL TVLPETPRYL IKRGDKNAAA LSLSRLRRLD
ITHPALVEEL AEIEANHQYE MALGPDSYKD ILFGEPHLGR RTFTGCCLQM LQQLTGVNFI
MYYGTTFFNN AGVGNPFKIS LIMQVINTAS TIPGLFVVES WGRRRLLMVG AIGMAICQLL
IAAFATASGS NNLSAQNKVL ITFVAIYIFF FAASWGPVVW VVTSEIYPLK VRAKSMSITT
ASNWFLNFGI AYGTPYMQTN SAASDESSID LGSKVFFVWG AFCIVAVGFV WCMVYETSKI
SLEQIDEMYE RVDHAWHSRR FEPSWSFQEM RDLGFSDGGI PPTQQLQQQP QQPQQQQQQH
HQQQQHQLQV DLQQSQSRTS NSSTSQTDTG GSNNTGASQD DKLVASLGNI DLSY
