ID   RCO1_NEUCR              Reviewed;         604 AA.
AC   P78706; Q7SBB8;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 2.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Transcriptional repressor rco-1;
GN   Name=rco-1; ORFNames=NCU06205;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DISRUPTION PHENOTYPE.
RX   PubMed=8887652; DOI=10.1128/mcb.16.11.6218;
RA   Yamashiro C.T., Ebbole D.J., Lee B.-U., Brown R.E., Bourland C., Madi L.,
RA   Yanofsky C.;
RT   "Characterization of rco-1 of Neurospora crassa, a pleiotropic gene
RT   affecting growth and development that encodes a homolog of Tup1 of
RT   Saccharomyces cerevisiae.";
RL   Mol. Cell. Biol. 16:6218-6228(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Represses transcription by RNA polymerase II. May be involved
CC       at several stages of conidiation and other growth and development
CC       processes. Appears to regulate genes that are expressed in asexual and
CC       sexual spore pathways.
CC   -!- DISRUPTION PHENOTYPE: Mutant are aconidial, female sterile, have
CC       reduced growth rates and form hyphae that coil in a counterclockwise
CC       direction, opposite to that of the wild-type.
CC       {ECO:0000269|PubMed:8887652}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U57061; AAB37245.1; -; Genomic_DNA.
DR   EMBL; CM002238; EAA33685.1; -; Genomic_DNA.
DR   RefSeq; XP_962921.1; XM_957828.3.
DR   AlphaFoldDB; P78706; -.
DR   SMR; P78706; -.
DR   STRING; 5141.EFNCRP00000006007; -.
DR   PRIDE; P78706; -.
DR   EnsemblFungi; EAA33685; EAA33685; NCU06205.
DR   GeneID; 3879069; -.
DR   KEGG; ncr:NCU06205; -.
DR   VEuPathDB; FungiDB:NCU06205; -.
DR   HOGENOM; CLU_000288_57_23_1; -.
DR   InParanoid; P78706; -.
DR   OMA; FDTQMRQ; -.
DR   Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR   GO; GO:0005634; C:nucleus; IEA:EnsemblFungi.
DR   GO; GO:0017053; C:transcription repressor complex; IEA:EnsemblFungi.
DR   GO; GO:0042393; F:histone binding; IEA:EnsemblFungi.
DR   GO; GO:0042826; F:histone deacetylase binding; IEA:EnsemblFungi.
DR   GO; GO:0036033; F:mediator complex binding; IEA:EnsemblFungi.
DR   GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:EnsemblFungi.
DR   GO; GO:0003714; F:transcription corepressor activity; IEA:EnsemblFungi.
DR   GO; GO:0000433; P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose; IEA:EnsemblFungi.
DR   GO; GO:0048315; P:conidium formation; IEA:UniProtKB-KW.
DR   GO; GO:0043486; P:histone exchange; IEA:EnsemblFungi.
DR   GO; GO:0006972; P:hyperosmotic response; IEA:EnsemblFungi.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR   GO; GO:1900192; P:positive regulation of single-species biofilm formation; IEA:EnsemblFungi.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR   GO; GO:0060256; P:regulation of flocculation; IEA:EnsemblFungi.
DR   GO; GO:2000217; P:regulation of invasive growth in response to glucose limitation; IEA:EnsemblFungi.
DR   GO; GO:2001020; P:regulation of response to DNA damage stimulus; IEA:EnsemblFungi.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR013890; Tscrpt_rep_Tup1_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF08581; Tup_N; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 4.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   4: Predicted;
KW   Conidiation; Reference proteome; Repeat; Repressor; Sporulation;
KW   Transcription; Transcription regulation; WD repeat.
FT   CHAIN           1..604
FT                   /note="Transcriptional repressor rco-1"
FT                   /id="PRO_0000051197"
FT   REPEAT          295..324
FT                   /note="WD 1"
FT   REPEAT          342..372
FT                   /note="WD 2"
FT   REPEAT          384..414
FT                   /note="WD 3"
FT   REPEAT          425..455
FT                   /note="WD 4"
FT   REPEAT          469..499
FT                   /note="WD 5"
FT   REPEAT          523..553
FT                   /note="WD 6"
FT   REPEAT          565..600
FT                   /note="WD 7"
FT   REGION          87..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          124..264
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..166
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        211..233
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        581
FT                   /note="P -> S (in Ref. 1; AAB37245)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   604 AA;  66086 MW;  9951B5E558B529A6 CRC64;
     MSMYPHRPIA GAPIQNMGRL NELLDGIRME FESQARQYET CQHDLATQLQ ELQVIREKVF
     QMEQHQMNVK QKYEDEIALL RRQLEARGGA PGNMNPPPQH PGQQQPPAIG LGSNVFSAIM
     AGQGGQALVP PPPPPQQQEQ PAHMPAPPGL QGPPPPPPPP SQQPPFQQQY QGPQGPGNFP
     PQPPQSTASP GPAGKRGIGR PPAGGPATPQ INTPIPYNGG PAQSPQVPTH PTPDHTRMAQ
     HHQPPPPPPS QTNALSELDP DRLPNHIKKM KDDWWVIFNA AVPRVLDVEL VHTLQHESVV
     CCVRFSMDGK YVATGCNRSA QIYDVETGEK LCILQDENID LTGDLYIRSV CFSPDGKYLA
     TGAEDKLIRV WDIQSRTIRN TFHGHEQDIY SLDFSRDGRT IASGSGDRTV RLWDIETGQN
     TSVLSIEDGV TTVAISPDKQ FVAAGSLDKS VRVWDMRGYL AERLEGPDGH KDSVYSVAFS
     PDGRNLVSGS LDKTIKMWEL SAPRGIPSSA PPKGGRCIKT FEGHRDFVLS VALTPDSQWV
     LSGSKDRGVQ FWDPRTGHTQ LMLQGHKNSV ISVAPSPVTG PNGVGYFATG SGDMRARIWS
     YSRI