RCNR_ECOLI
ID RCNR_ECOLI Reviewed; 90 AA.
AC P64530; P76424; Q2MAX0;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Transcriptional repressor RcnR;
GN Name=rcnR; Synonyms=yohL; OrderedLocusNames=b2105, JW2092;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [3]
RP FUNCTION, AND DNA-BINDING.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=16956381; DOI=10.1111/j.1365-2958.2006.05369.x;
RA Iwig J.S., Rowe J.L., Chivers P.T.;
RT "Nickel homeostasis in Escherichia coli - the rcnR-rcnA efflux pathway and
RT its linkage to NikR function.";
RL Mol. Microbiol. 62:252-262(2006).
RN [4]
RP FUNCTION.
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=17120142; DOI=10.1007/s10534-006-9039-6;
RA Koch D., Nies D.H., Grass G.;
RT "The RcnRA (YohLM) system of Escherichia coli: a connection between nickel,
RT cobalt and iron homeostasis.";
RL BioMetals 20:759-771(2007).
CC -!- FUNCTION: Repressor of rcnA expression. Acts by binding specifically to
CC the rcnA promoter in the absence of nickel and cobalt. In the presence
CC of one of these metals, it has a weaker affinity for rcnA promoter.
CC {ECO:0000269|PubMed:16956381, ECO:0000269|PubMed:17120142}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FrmR/RcnR family. {ECO:0000305}.
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DR EMBL; U00096; AAC75166.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76586.1; -; Genomic_DNA.
DR PIR; H64977; H64977.
DR RefSeq; NP_416608.1; NC_000913.3.
DR RefSeq; WP_000019944.1; NZ_STEB01000002.1.
DR AlphaFoldDB; P64530; -.
DR SMR; P64530; -.
DR BioGRID; 4261164; 9.
DR BioGRID; 851449; 4.
DR IntAct; P64530; 8.
DR STRING; 511145.b2105; -.
DR jPOST; P64530; -.
DR PaxDb; P64530; -.
DR PRIDE; P64530; -.
DR EnsemblBacteria; AAC75166; AAC75166; b2105.
DR EnsemblBacteria; BAE76586; BAE76586; BAE76586.
DR GeneID; 67417885; -.
DR GeneID; 947114; -.
DR KEGG; ecj:JW2092; -.
DR KEGG; eco:b2105; -.
DR PATRIC; fig|1411691.4.peg.142; -.
DR EchoBASE; EB3823; -.
DR eggNOG; COG1937; Bacteria.
DR HOGENOM; CLU_130332_3_0_6; -.
DR InParanoid; P64530; -.
DR OMA; EHECAEI; -.
DR PhylomeDB; P64530; -.
DR BioCyc; EcoCyc:G7137-MON; -.
DR PRO; PR:P64530; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:EcoCyc.
DR Gene3D; 1.20.58.1000; -; 1.
DR InterPro; IPR003735; Metal_Tscrpt_repr.
DR InterPro; IPR038390; Metal_Tscrpt_repr_sf.
DR PANTHER; PTHR33677; PTHR33677; 1.
DR Pfam; PF02583; Trns_repr_metal; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..90
FT /note="Transcriptional repressor RcnR"
FT /id="PRO_0000169143"
SQ SEQUENCE 90 AA; 10134 MW; BEF3E5AE971AA2F6 CRC64;
MSHTIRDKQK LKARASKIQG QVVALKKMLD EPHECAAVLQ QIAAIRGAVN GLMREVIKGH
LTEHIVHQGD ELKREEDLDV VLKVLDSYIK
