ID   RCNR_ECOL6              Reviewed;          90 AA.
AC   P64531; P76424;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Transcriptional repressor RcnR;
GN   Name=rcnR; OrderedLocusNames=c2632;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Repressor of rcnA expression. Acts by binding specifically to
CC       the rcnA promoter in the absence of nickel and cobalt. In the presence
CC       of one of these metals, it has a weaker affinity for rcnA promoter (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FrmR/RcnR family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE014075; AAN81088.1; -; Genomic_DNA.
DR   RefSeq; WP_000019944.1; NC_004431.1.
DR   AlphaFoldDB; P64531; -.
DR   SMR; P64531; -.
DR   STRING; 199310.c2632; -.
DR   EnsemblBacteria; AAN81088; AAN81088; c2632.
DR   GeneID; 67417885; -.
DR   KEGG; ecc:c2632; -.
DR   eggNOG; COG1937; Bacteria.
DR   HOGENOM; CLU_130332_3_0_6; -.
DR   OMA; EHECAEI; -.
DR   BioCyc; ECOL199310:C2632-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProt.
DR   Gene3D; 1.20.58.1000; -; 1.
DR   InterPro; IPR003735; Metal_Tscrpt_repr.
DR   InterPro; IPR038390; Metal_Tscrpt_repr_sf.
DR   PANTHER; PTHR33677; PTHR33677; 1.
DR   Pfam; PF02583; Trns_repr_metal; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..90
FT                   /note="Transcriptional repressor RcnR"
FT                   /id="PRO_0000169145"
SQ   SEQUENCE   90 AA;  10134 MW;  BEF3E5AE971AA2F6 CRC64;
     MSHTIRDKQK LKARASKIQG QVVALKKMLD EPHECAAVLQ QIAAIRGAVN GLMREVIKGH
     LTEHIVHQGD ELKREEDLDV VLKVLDSYIK