ID   RCNA_SALTY              Reviewed;         288 AA.
AC   Q8ZM94;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Nickel/cobalt efflux system RcnA;
GN   Name=rcnA; OrderedLocusNames=STM3024;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Efflux system for nickel and cobalt. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- INDUCTION: By nickel and cobalt. Transcriptionally repressed by RcnR
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NiCoT transporter (TC 2.A.52) family. RcnA
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AE006468; AAL21900.1; -; Genomic_DNA.
DR   RefSeq; NP_461941.1; NC_003197.2.
DR   RefSeq; WP_000503682.1; NC_003197.2.
DR   AlphaFoldDB; Q8ZM94; -.
DR   STRING; 99287.STM3024; -.
DR   PaxDb; Q8ZM94; -.
DR   EnsemblBacteria; AAL21900; AAL21900; STM3024.
DR   GeneID; 1254547; -.
DR   KEGG; stm:STM3024; -.
DR   PATRIC; fig|99287.12.peg.3200; -.
DR   HOGENOM; CLU_058605_2_0_6; -.
DR   PhylomeDB; Q8ZM94; -.
DR   BioCyc; SENT99287:STM3024-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0046583; F:cation efflux transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015099; F:nickel cation transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006824; P:cobalt ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0035784; P:nickel cation homeostasis; IBA:GO_Central.
DR   GO; GO:0032025; P:response to cobalt ion; IBA:GO_Central.
DR   GO; GO:0010045; P:response to nickel cation; IBA:GO_Central.
DR   InterPro; IPR011541; Ni/Co_transpt_high_affinity.
DR   Pfam; PF03824; NicO; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Cobalt; Cobalt transport;
KW   Ion transport; Membrane; Nickel; Nickel transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..288
FT                   /note="Nickel/cobalt efflux system RcnA"
FT                   /id="PRO_0000194013"
FT   TOPO_DOM        1..12
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        34..51
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        73..85
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        107..188
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        210..223
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        245..265
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        266..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        287..288
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          122..166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   288 AA;  31541 MW;  05FFA7D4BB1A8DE8 CRC64;
     MGEFSTLLQQ GNGWFFIPSA ILLGILHGLE PGHSKTMMAA FIIAIKGTVK QAVMLGLAAT
     LSHTAIVWLI ALGGMYLSRA FTAQSVEPWL QLISAIIILS TACWMFWRTW RGEQQWLAGN
     HHHDHDHDHD HDHDHDHDHD HDHDHDHDHH GHIHPEGATS KAYQDAHERA HAADIQRRFD
     GQTVTNGQIL LFGLTGGLIP CPAAITVLLI CIQLKAFTLG ATMVLSFSLG LALTLVTVGV
     GAAISVQQAA KRWSGFSTLA RRAPYFSSIL IGLVGVYMGI HGYTGIMQ