ID   RCNA_SALPB              Reviewed;         288 AA.
AC   A9N3J5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Nickel/cobalt efflux system RcnA;
GN   Name=rcnA; OrderedLocusNames=SPAB_03765;
OS   Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=1016998;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1250 / SPB7;
RG   The Salmonella enterica serovar Paratyphi B Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S.,
RA   Fulton R., Cordes M., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W.,
RA   Johnson M., Thiruvilangam P., Wilson R.;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Efflux system for nickel and cobalt. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- INDUCTION: By nickel and cobalt. Transcriptionally repressed by RcnR
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NiCoT transporter (TC 2.A.52) family. RcnA
CC       subfamily. {ECO:0000305}.
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DR   EMBL; CP000886; ABX69098.1; -; Genomic_DNA.
DR   RefSeq; WP_000503700.1; NC_010102.1.
DR   AlphaFoldDB; A9N3J5; -.
DR   KEGG; spq:SPAB_03765; -.
DR   PATRIC; fig|1016998.12.peg.3545; -.
DR   HOGENOM; CLU_058605_2_0_6; -.
DR   OMA; HALEPGH; -.
DR   BioCyc; SENT1016998:SPAB_RS15325-MON; -.
DR   Proteomes; UP000008556; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0015099; F:nickel cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006824; P:cobalt ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR011541; Ni/Co_transpt_high_affinity.
DR   Pfam; PF03824; NicO; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Cobalt; Cobalt transport;
KW   Ion transport; Membrane; Nickel; Nickel transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..288
FT                   /note="Nickel/cobalt efflux system RcnA"
FT                   /id="PRO_0000333788"
FT   TOPO_DOM        1..12
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        34..51
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        73..85
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        107..188
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        210..223
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        245..265
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        266..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        287..288
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          123..166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   288 AA;  31483 MW;  3BCE45C694CA8F15 CRC64;
     MGEFSTLLQQ GNGWFFIPSA ILLGILHGLE PGHSKTMMAA FIIAIKGTVK QAVMLGLAAT
     LSHTAIVWLI ALGGMYLSRA FTAQSVEPWL QLISAIIILS TACWMFWRTW RGEQQWLAGN
     HHHDHDHGHD HDHDHDHDHD HDHDHDHDHH GHIHPEGATS KAYQDAHERA HAADIQRRFD
     GQTVTNGQIL LFGLTGGLIP CPAAITVLLI CIQLKAFTLG ATMVLSFSLG LALTLVTVGV
     GAAISVQQAA KRWSGFSTLA RRAPYFSSIL IGLVGVYMGI HGYTGIMQ