RACA_ALKHC
ID RACA_ALKHC Reviewed; 174 AA.
AC Q9KC68;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Chromosome-anchoring protein RacA {ECO:0000255|HAMAP-Rule:MF_01170};
GN Name=racA {ECO:0000255|HAMAP-Rule:MF_01170}; OrderedLocusNames=BH1706;
OS Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS / JCM 9153 / C-125) (Bacillus halodurans).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX NCBI_TaxID=272558;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT and genomic sequence comparison with Bacillus subtilis.";
RL Nucleic Acids Res. 28:4317-4331(2000).
CC -!- FUNCTION: Required for the formation of axial filaments and for
CC anchoring the origin regions at the cell poles in sporulating cells,
CC thus ensuring proper chromosome segregation in the prespore. Binds in a
CC dispersed manner throughout the chromosome but preferentially to sites
CC clustered in the origin portion of the chromosome, causing condensation
CC of the chromosome and its remodeling into an elongated, anchored
CC structure. {ECO:0000255|HAMAP-Rule:MF_01170}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01170}.
CC Note=Localizes to cell poles and nucleoid. {ECO:0000255|HAMAP-
CC Rule:MF_01170}.
CC -!- SIMILARITY: Belongs to the RacA family. {ECO:0000255|HAMAP-
CC Rule:MF_01170}.
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DR EMBL; BA000004; BAB05425.1; -; Genomic_DNA.
DR PIR; B83863; B83863.
DR RefSeq; WP_010897867.1; NC_002570.2.
DR AlphaFoldDB; Q9KC68; -.
DR SMR; Q9KC68; -.
DR STRING; 272558.10174323; -.
DR EnsemblBacteria; BAB05425; BAB05425; BAB05425.
DR KEGG; bha:BH1706; -.
DR eggNOG; COG0789; Bacteria.
DR HOGENOM; CLU_111022_0_0_9; -.
DR OMA; WVKQLNL; -.
DR OrthoDB; 1287443at2; -.
DR Proteomes; UP000001258; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008356; P:asymmetric cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-UniRule.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01170; RacA; 1.
DR InterPro; IPR023522; Chrosome_anchoring_RacA.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR000551; MerR-type_HTH_dom.
DR Pfam; PF13411; MerR_1; 1.
DR SUPFAM; SSF46955; SSF46955; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Chromosome partition; Coiled coil; Cytoplasm;
KW DNA-binding; Reference proteome; Sporulation.
FT CHAIN 1..174
FT /note="Chromosome-anchoring protein RacA"
FT /id="PRO_0000224155"
FT DNA_BIND 7..27
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01170"
FT COILED 84..157
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01170"
SQ SEQUENCE 174 AA; 20554 MW; F20EF4875665A2D4 CRC64;
MAVQWKTKEV SEQLGVNPTT VQRWVKFFGI QCETNEHGHL LFEKEHLTVL KAIQNQLKSG
KKMRDVVIEE NEQLIQKPET QPMVATEQYE QRTKQFMEKI AELEKQLSQK ADDVVSYQIL
KHRAEIDEMF KTLQSLELRM AKVEEQLEKQ QEEFPLAAGD VPKRKRSFMR LFSF
