ID   RABEK_BOVIN             Reviewed;         372 AA.
AC   Q5EA50;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Rab9 effector protein with kelch motifs;
GN   Name=RABEPK;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Rab9 effector required for endosome to trans-Golgi network
CC       (TGN) transport. {ECO:0000250|UniProtKB:Q7Z6M1}.
CC   -!- SUBUNIT: Interacts with PIKFYVE; the interaction recruits RABEPK to the
CC       endosomal membrane. Interacts with RAB9 in its GTP-bound conformation.
CC       {ECO:0000250|UniProtKB:Q7Z6M1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q7Z6M1}.
CC       Endosome membrane {ECO:0000250|UniProtKB:Q7Z6M1}. Note=Interaction with
CC       PIKFYVE and subsequent phosphorylation recruits it to the endosomal
CC       membrane. {ECO:0000250|UniProtKB:Q7Z6M1}.
CC   -!- PTM: Phosphorylated on Ser residues by PIKFYVE.
CC       {ECO:0000250|UniProtKB:Q7Z6M1}.
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DR   EMBL; BT020719; AAX08736.1; -; mRNA.
DR   EMBL; BT021185; AAX31367.1; -; mRNA.
DR   EMBL; BC111169; AAI11170.1; -; mRNA.
DR   RefSeq; NP_001030476.1; NM_001035399.1.
DR   AlphaFoldDB; Q5EA50; -.
DR   SMR; Q5EA50; -.
DR   STRING; 9913.ENSBTAP00000020093; -.
DR   PaxDb; Q5EA50; -.
DR   PRIDE; Q5EA50; -.
DR   Ensembl; ENSBTAT00000020093; ENSBTAP00000020093; ENSBTAG00000015098.
DR   Ensembl; ENSBTAT00000074576; ENSBTAP00000066540; ENSBTAG00000015098.
DR   GeneID; 533613; -.
DR   KEGG; bta:533613; -.
DR   CTD; 10244; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015098; -.
DR   VGNC; VGNC:33669; RABEPK.
DR   eggNOG; KOG0379; Eukaryota.
DR   GeneTree; ENSGT00940000158763; -.
DR   HOGENOM; CLU_045313_0_0_1; -.
DR   InParanoid; Q5EA50; -.
DR   OMA; HEWDIPE; -.
DR   OrthoDB; 933937at2759; -.
DR   TreeFam; TF329153; -.
DR   Reactome; R-BTA-6811440; Retrograde transport at the Trans-Golgi-Network.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000015098; Expressed in semen and 105 other tissues.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.120.10.80; -; 2.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011498; Kelch_2.
DR   Pfam; PF01344; Kelch_1; 1.
DR   Pfam; PF07646; Kelch_2; 1.
DR   SUPFAM; SSF117281; SSF117281; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endosome; Kelch repeat; Membrane; Phosphoprotein;
KW   Reference proteome; Repeat.
FT   CHAIN           1..372
FT                   /note="Rab9 effector protein with kelch motifs"
FT                   /id="PRO_0000280615"
FT   REPEAT          49..95
FT                   /note="Kelch 1"
FT   REPEAT          100..146
FT                   /note="Kelch 2"
FT   REPEAT          151..203
FT                   /note="Kelch 3"
FT   REPEAT          204..250
FT                   /note="Kelch 4"
FT   REPEAT          254..303
FT                   /note="Kelch 5"
FT   REPEAT          349..372
FT                   /note="Kelch 6"
FT   REGION          309..341
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        315..331
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   372 AA;  40362 MW;  7A9169FEC2B99B93 CRC64;
     MKQLPVLEPG DKPRKETWYT LTLVGDSPCA RVGHSCSYLP PVGDAERGKV FIVGGADPNR
     SFSDVHTIDL GTHQWDLATS EGLLPRYEHT SFIPSCTPHS IWVFGGADQS GNRNCLQVLN
     PDTRTWTTPE VTGPPPSPRT FHTSSAAIGD QLYVFGGGER GAQPVQDVQL HVFDANTLTW
     SQPETHGKPP SPRHGHVMVA AGTKLFIHGG LAGDNFYDDL HCIDISDMKW QKLRPTGAAP
     TGCAAHSAVA VGKHLYVFGG MTPTGALNTM YQYHIEKQHW TLLKFENSPP TGRLDHSMCI
     IPWPGTCTSE KEDSNSATVN RDAEKGDSTE KGVTQGGDSQ EESQADTLLC FVFGGMNTEG
     EIYDDCIVTA VD